Anti-Mycobacterium tuberculosis activity of fungus Phomopsis stipata

Detalhes bibliográficos
Autor(a) principal: Prince, Karina Andrade de [UNESP]
Data de Publicação: 2012
Outros Autores: Sordi, Renata [UNESP], Pavan, Fernando Rogério [UNESP], Santos, Adolfo Carlos Barreto [UNESP], Araujo, Angela R. [UNESP], Leite, Sergio R.A. [UNESP], Leite, Clarice Queico Fujimura [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S1517-83822012000100024
http://hdl.handle.net/11449/7403
Resumo: Our purpose was to determine the anti-Mycobacterium tuberculosis activity of the metabolites produced by the endophitic fungus Phomopsis stipata (Lib.) B. Sutton, (Diaporthaceae), cultivated in different media. The antimycobacterial activity was assessed through the Resazurin Microtiter Assay (REMA) and the cytotoxicity test performed on macrophage cell line. The extracts derived from fungi grown on Corn Medium and Potato Dextrose Broth presented the smallest values of Minimum Inhibitory Concentration (MIC) and low cytotoxicity, which implies a high selectivity index. This is the first report on the chemical composition and antitubercular activity of metabolites of P. stipata, as well as the influence of culture medium on these properties.
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spelling Anti-Mycobacterium tuberculosis activity of fungus Phomopsis stipataPhomopsis stipataantimycobacterial activityMycobacterium tuberculosisOur purpose was to determine the anti-Mycobacterium tuberculosis activity of the metabolites produced by the endophitic fungus Phomopsis stipata (Lib.) B. Sutton, (Diaporthaceae), cultivated in different media. The antimycobacterial activity was assessed through the Resazurin Microtiter Assay (REMA) and the cytotoxicity test performed on macrophage cell line. The extracts derived from fungi grown on Corn Medium and Potato Dextrose Broth presented the smallest values of Minimum Inhibitory Concentration (MIC) and low cytotoxicity, which implies a high selectivity index. This is the first report on the chemical composition and antitubercular activity of metabolites of P. stipata, as well as the influence of culture medium on these properties.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Estadual PaulistaFaculdades Integradas PitágorasUniversidade Estadual PaulistaFAPESP: 11/11593-7FAPESP: 08/10390-2FAPESP: 06/50680FAPESP: 09/06499-1Sociedade Brasileira de MicrobiologiaUniversidade Estadual Paulista (Unesp)Faculdades Integradas PitágorasPrince, Karina Andrade de [UNESP]Sordi, Renata [UNESP]Pavan, Fernando Rogério [UNESP]Santos, Adolfo Carlos Barreto [UNESP]Araujo, Angela R. [UNESP]Leite, Sergio R.A. [UNESP]Leite, Clarice Queico Fujimura [UNESP]2014-05-20T13:24:07Z2014-05-20T13:24:07Z2012-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article224-229application/pdfhttp://dx.doi.org/10.1590/S1517-83822012000100024Brazilian Journal of Microbiology. Sociedade Brasileira de Microbiologia, v. 43, n. 1, p. 224-229, 2012.1517-8382http://hdl.handle.net/11449/740310.1590/S1517-83822012000100024S1517-83822012000100024WOS:000303939800024S1517-83822012000100024.pdf21145707743498590000-0001-7616-9652SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Microbiology1.8100,630info:eu-repo/semantics/openAccess2024-06-24T13:08:14Zoai:repositorio.unesp.br:11449/7403Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:49:49.129753Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Anti-Mycobacterium tuberculosis activity of fungus Phomopsis stipata
title Anti-Mycobacterium tuberculosis activity of fungus Phomopsis stipata
spellingShingle Anti-Mycobacterium tuberculosis activity of fungus Phomopsis stipata
Prince, Karina Andrade de [UNESP]
Phomopsis stipata
antimycobacterial activity
Mycobacterium tuberculosis
title_short Anti-Mycobacterium tuberculosis activity of fungus Phomopsis stipata
title_full Anti-Mycobacterium tuberculosis activity of fungus Phomopsis stipata
title_fullStr Anti-Mycobacterium tuberculosis activity of fungus Phomopsis stipata
title_full_unstemmed Anti-Mycobacterium tuberculosis activity of fungus Phomopsis stipata
title_sort Anti-Mycobacterium tuberculosis activity of fungus Phomopsis stipata
author Prince, Karina Andrade de [UNESP]
author_facet Prince, Karina Andrade de [UNESP]
Sordi, Renata [UNESP]
Pavan, Fernando Rogério [UNESP]
Santos, Adolfo Carlos Barreto [UNESP]
Araujo, Angela R. [UNESP]
Leite, Sergio R.A. [UNESP]
Leite, Clarice Queico Fujimura [UNESP]
author_role author
author2 Sordi, Renata [UNESP]
Pavan, Fernando Rogério [UNESP]
Santos, Adolfo Carlos Barreto [UNESP]
Araujo, Angela R. [UNESP]
Leite, Sergio R.A. [UNESP]
Leite, Clarice Queico Fujimura [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Faculdades Integradas Pitágoras
dc.contributor.author.fl_str_mv Prince, Karina Andrade de [UNESP]
Sordi, Renata [UNESP]
Pavan, Fernando Rogério [UNESP]
Santos, Adolfo Carlos Barreto [UNESP]
Araujo, Angela R. [UNESP]
Leite, Sergio R.A. [UNESP]
Leite, Clarice Queico Fujimura [UNESP]
dc.subject.por.fl_str_mv Phomopsis stipata
antimycobacterial activity
Mycobacterium tuberculosis
topic Phomopsis stipata
antimycobacterial activity
Mycobacterium tuberculosis
description Our purpose was to determine the anti-Mycobacterium tuberculosis activity of the metabolites produced by the endophitic fungus Phomopsis stipata (Lib.) B. Sutton, (Diaporthaceae), cultivated in different media. The antimycobacterial activity was assessed through the Resazurin Microtiter Assay (REMA) and the cytotoxicity test performed on macrophage cell line. The extracts derived from fungi grown on Corn Medium and Potato Dextrose Broth presented the smallest values of Minimum Inhibitory Concentration (MIC) and low cytotoxicity, which implies a high selectivity index. This is the first report on the chemical composition and antitubercular activity of metabolites of P. stipata, as well as the influence of culture medium on these properties.
publishDate 2012
dc.date.none.fl_str_mv 2012-03-01
2014-05-20T13:24:07Z
2014-05-20T13:24:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1517-83822012000100024
Brazilian Journal of Microbiology. Sociedade Brasileira de Microbiologia, v. 43, n. 1, p. 224-229, 2012.
1517-8382
http://hdl.handle.net/11449/7403
10.1590/S1517-83822012000100024
S1517-83822012000100024
WOS:000303939800024
S1517-83822012000100024.pdf
2114570774349859
0000-0001-7616-9652
url http://dx.doi.org/10.1590/S1517-83822012000100024
http://hdl.handle.net/11449/7403
identifier_str_mv Brazilian Journal of Microbiology. Sociedade Brasileira de Microbiologia, v. 43, n. 1, p. 224-229, 2012.
1517-8382
10.1590/S1517-83822012000100024
S1517-83822012000100024
WOS:000303939800024
S1517-83822012000100024.pdf
2114570774349859
0000-0001-7616-9652
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal of Microbiology
1.810
0,630
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 224-229
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129362950619136

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