Antioxidant factors, nitric oxide levels, and cellular damage in leprosy patients

Detalhes bibliográficos
Autor(a) principal: Schalcher,Taysa Ribeiro
Data de Publicação: 2013
Outros Autores: Vieira,Jose Luiz Fernandes, Salgado,Claudio Guedes, Borges,Rosivaldo dos Santos, Monteiro,Marta Chagas
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Sociedade Brasileira de Medicina Tropical
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000500645
Resumo: Introduction The immune response caused by Mycobacterium leprae is a risk factor for the development of oxidative stress (OS) in leprosy patients. This study aimed to assess OS in leprosy patients before the use of a multidrug therapy. Methods We evaluated the nitric oxide (NO) concentration; antioxidant capacity; levels of malondialdehyde, methemoglobin and reduced glutathione; and the activity of catalase and superoxide dismutase (SOD) in leprosy patients. Results We observed lower SOD activity in these leprosy patients; however, the NO levels and antioxidant capacity were increased. Conclusions The infectious process in response to M. leprae could primarily be responsible for the OS observed in these patients.
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spelling Antioxidant factors, nitric oxide levels, and cellular damage in leprosy patientsMycobacterium lepraeOxidative stressLeprosy patients Introduction The immune response caused by Mycobacterium leprae is a risk factor for the development of oxidative stress (OS) in leprosy patients. This study aimed to assess OS in leprosy patients before the use of a multidrug therapy. Methods We evaluated the nitric oxide (NO) concentration; antioxidant capacity; levels of malondialdehyde, methemoglobin and reduced glutathione; and the activity of catalase and superoxide dismutase (SOD) in leprosy patients. Results We observed lower SOD activity in these leprosy patients; however, the NO levels and antioxidant capacity were increased. Conclusions The infectious process in response to M. leprae could primarily be responsible for the OS observed in these patients. Sociedade Brasileira de Medicina Tropical - SBMT2013-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000500645Revista da Sociedade Brasileira de Medicina Tropical v.46 n.5 2013reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/0037-8682-1506-2013info:eu-repo/semantics/openAccessSchalcher,Taysa RibeiroVieira,Jose Luiz FernandesSalgado,Claudio GuedesBorges,Rosivaldo dos SantosMonteiro,Marta Chagaseng2013-11-22T00:00:00Zoai:scielo:S0037-86822013000500645Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2013-11-22T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false
dc.title.none.fl_str_mv Antioxidant factors, nitric oxide levels, and cellular damage in leprosy patients
title Antioxidant factors, nitric oxide levels, and cellular damage in leprosy patients
spellingShingle Antioxidant factors, nitric oxide levels, and cellular damage in leprosy patients
Schalcher,Taysa Ribeiro
Mycobacterium leprae
Oxidative stress
Leprosy patients
title_short Antioxidant factors, nitric oxide levels, and cellular damage in leprosy patients
title_full Antioxidant factors, nitric oxide levels, and cellular damage in leprosy patients
title_fullStr Antioxidant factors, nitric oxide levels, and cellular damage in leprosy patients
title_full_unstemmed Antioxidant factors, nitric oxide levels, and cellular damage in leprosy patients
title_sort Antioxidant factors, nitric oxide levels, and cellular damage in leprosy patients
author Schalcher,Taysa Ribeiro
author_facet Schalcher,Taysa Ribeiro
Vieira,Jose Luiz Fernandes
Salgado,Claudio Guedes
Borges,Rosivaldo dos Santos
Monteiro,Marta Chagas
author_role author
author2 Vieira,Jose Luiz Fernandes
Salgado,Claudio Guedes
Borges,Rosivaldo dos Santos
Monteiro,Marta Chagas
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Schalcher,Taysa Ribeiro
Vieira,Jose Luiz Fernandes
Salgado,Claudio Guedes
Borges,Rosivaldo dos Santos
Monteiro,Marta Chagas
dc.subject.por.fl_str_mv Mycobacterium leprae
Oxidative stress
Leprosy patients
topic Mycobacterium leprae
Oxidative stress
Leprosy patients
description Introduction The immune response caused by Mycobacterium leprae is a risk factor for the development of oxidative stress (OS) in leprosy patients. This study aimed to assess OS in leprosy patients before the use of a multidrug therapy. Methods We evaluated the nitric oxide (NO) concentration; antioxidant capacity; levels of malondialdehyde, methemoglobin and reduced glutathione; and the activity of catalase and superoxide dismutase (SOD) in leprosy patients. Results We observed lower SOD activity in these leprosy patients; however, the NO levels and antioxidant capacity were increased. Conclusions The infectious process in response to M. leprae could primarily be responsible for the OS observed in these patients.
publishDate 2013
dc.date.none.fl_str_mv 2013-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000500645
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000500645
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0037-8682-1506-2013
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
dc.source.none.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical v.46 n.5 2013
reponame:Revista da Sociedade Brasileira de Medicina Tropical
instname:Sociedade Brasileira de Medicina Tropical (SBMT)
instacron:SBMT
instname_str Sociedade Brasileira de Medicina Tropical (SBMT)
instacron_str SBMT
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reponame_str Revista da Sociedade Brasileira de Medicina Tropical
collection Revista da Sociedade Brasileira de Medicina Tropical
repository.name.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)
repository.mail.fl_str_mv ||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br
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