Irisin and troponin I expression in dialysis patients submitted to remote ischemic preconditioning: a pilot study
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal Brasileiro de Nefrologia |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002020000100047 |
Resumo: | ABSTRACT Background: Renal replacement therapy continues to be related to high hospitalization rates and poor quality of life. All-cause morbidity and mortality in renal replacement therapy in greater than 20% per year, being 44 times greater when diabetes is present, and over 10 times that of the general population. Regardless of treatment, the 5-year survival is 40%, surpassing many types of cancers. Irisin is a hormone that converts white adipose tissue into beige adipose tissue, aggregating positive effects like fat mass control, glucose tolerance, insulin resistance, prevention of muscle loss, and reduction in systemic inflammation. Objectives: To determine the serum levels of troponin I in hemodialysis patients submitted to remote ischemic preconditioning (RIPC) associated with irisin expression. Methods: This was a prospective, randomized, double-blind clinical trial with patients with chronic kidney disease submitted to hemodialysis for a 6-month period. Troponin I, IL-6, urea, TNF-α, and creatinine levels were determined from blood samples. The expressions of irisin, thioredoxin, Nf-kb, GPX4, selenoprotein and GADPH were also evaluated by RT-PCR. Results: Samples from 14 hypertensive patients were analyzed, 9 (64.3%) of whom were type 2 diabetics, aged 44-64 years, and 50% of each sex. The difference between pre- and post-intervention levels of troponin I was not significant. No differences were verified between the RIPC and control groups, except for IL-6, although a significant correlation was observed between irisin and troponin I. Conclusion: Remote ischemic preconditioning did not modify irisin or troponin I expression, independent of the time of collection. |
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Jornal Brasileiro de Nefrologia |
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Irisin and troponin I expression in dialysis patients submitted to remote ischemic preconditioning: a pilot studyRenal DialysisHypertensionDiabetes MellitusBlood Chemical AnalysisTroponin IABSTRACT Background: Renal replacement therapy continues to be related to high hospitalization rates and poor quality of life. All-cause morbidity and mortality in renal replacement therapy in greater than 20% per year, being 44 times greater when diabetes is present, and over 10 times that of the general population. Regardless of treatment, the 5-year survival is 40%, surpassing many types of cancers. Irisin is a hormone that converts white adipose tissue into beige adipose tissue, aggregating positive effects like fat mass control, glucose tolerance, insulin resistance, prevention of muscle loss, and reduction in systemic inflammation. Objectives: To determine the serum levels of troponin I in hemodialysis patients submitted to remote ischemic preconditioning (RIPC) associated with irisin expression. Methods: This was a prospective, randomized, double-blind clinical trial with patients with chronic kidney disease submitted to hemodialysis for a 6-month period. Troponin I, IL-6, urea, TNF-α, and creatinine levels were determined from blood samples. The expressions of irisin, thioredoxin, Nf-kb, GPX4, selenoprotein and GADPH were also evaluated by RT-PCR. Results: Samples from 14 hypertensive patients were analyzed, 9 (64.3%) of whom were type 2 diabetics, aged 44-64 years, and 50% of each sex. The difference between pre- and post-intervention levels of troponin I was not significant. No differences were verified between the RIPC and control groups, except for IL-6, although a significant correlation was observed between irisin and troponin I. Conclusion: Remote ischemic preconditioning did not modify irisin or troponin I expression, independent of the time of collection.Sociedade Brasileira de Nefrologia2020-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002020000100047Brazilian Journal of Nephrology v.42 n.1 2020reponame:Jornal Brasileiro de Nefrologiainstname:Sociedade Brasileira de Nefrologia (SBN)instacron:SBN10.1590/2175-8239-jbn-2019-0051info:eu-repo/semantics/openAccessGehrke,Flávia de SousaGouveia,Mariana CarvalhoBarbosa,Carla Gabriela MarquesMurad,NeifReis,Beatriz da Costa Aguiar AlvesFonseca,Fernando Luiz AffonsoPereira,Edimar CristianoBacci,Marcelo Rodrigueseng2020-04-17T00:00:00Zoai:scielo:S0101-28002020000100047Revistahttp://www.bjn.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||jbn@sbn.org.br2175-82390101-2800opendoar:2020-04-17T00:00Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)false |
dc.title.none.fl_str_mv |
Irisin and troponin I expression in dialysis patients submitted to remote ischemic preconditioning: a pilot study |
title |
Irisin and troponin I expression in dialysis patients submitted to remote ischemic preconditioning: a pilot study |
spellingShingle |
Irisin and troponin I expression in dialysis patients submitted to remote ischemic preconditioning: a pilot study Gehrke,Flávia de Sousa Renal Dialysis Hypertension Diabetes Mellitus Blood Chemical Analysis Troponin I |
title_short |
Irisin and troponin I expression in dialysis patients submitted to remote ischemic preconditioning: a pilot study |
title_full |
Irisin and troponin I expression in dialysis patients submitted to remote ischemic preconditioning: a pilot study |
title_fullStr |
Irisin and troponin I expression in dialysis patients submitted to remote ischemic preconditioning: a pilot study |
title_full_unstemmed |
Irisin and troponin I expression in dialysis patients submitted to remote ischemic preconditioning: a pilot study |
title_sort |
Irisin and troponin I expression in dialysis patients submitted to remote ischemic preconditioning: a pilot study |
author |
Gehrke,Flávia de Sousa |
author_facet |
Gehrke,Flávia de Sousa Gouveia,Mariana Carvalho Barbosa,Carla Gabriela Marques Murad,Neif Reis,Beatriz da Costa Aguiar Alves Fonseca,Fernando Luiz Affonso Pereira,Edimar Cristiano Bacci,Marcelo Rodrigues |
author_role |
author |
author2 |
Gouveia,Mariana Carvalho Barbosa,Carla Gabriela Marques Murad,Neif Reis,Beatriz da Costa Aguiar Alves Fonseca,Fernando Luiz Affonso Pereira,Edimar Cristiano Bacci,Marcelo Rodrigues |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Gehrke,Flávia de Sousa Gouveia,Mariana Carvalho Barbosa,Carla Gabriela Marques Murad,Neif Reis,Beatriz da Costa Aguiar Alves Fonseca,Fernando Luiz Affonso Pereira,Edimar Cristiano Bacci,Marcelo Rodrigues |
dc.subject.por.fl_str_mv |
Renal Dialysis Hypertension Diabetes Mellitus Blood Chemical Analysis Troponin I |
topic |
Renal Dialysis Hypertension Diabetes Mellitus Blood Chemical Analysis Troponin I |
description |
ABSTRACT Background: Renal replacement therapy continues to be related to high hospitalization rates and poor quality of life. All-cause morbidity and mortality in renal replacement therapy in greater than 20% per year, being 44 times greater when diabetes is present, and over 10 times that of the general population. Regardless of treatment, the 5-year survival is 40%, surpassing many types of cancers. Irisin is a hormone that converts white adipose tissue into beige adipose tissue, aggregating positive effects like fat mass control, glucose tolerance, insulin resistance, prevention of muscle loss, and reduction in systemic inflammation. Objectives: To determine the serum levels of troponin I in hemodialysis patients submitted to remote ischemic preconditioning (RIPC) associated with irisin expression. Methods: This was a prospective, randomized, double-blind clinical trial with patients with chronic kidney disease submitted to hemodialysis for a 6-month period. Troponin I, IL-6, urea, TNF-α, and creatinine levels were determined from blood samples. The expressions of irisin, thioredoxin, Nf-kb, GPX4, selenoprotein and GADPH were also evaluated by RT-PCR. Results: Samples from 14 hypertensive patients were analyzed, 9 (64.3%) of whom were type 2 diabetics, aged 44-64 years, and 50% of each sex. The difference between pre- and post-intervention levels of troponin I was not significant. No differences were verified between the RIPC and control groups, except for IL-6, although a significant correlation was observed between irisin and troponin I. Conclusion: Remote ischemic preconditioning did not modify irisin or troponin I expression, independent of the time of collection. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002020000100047 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002020000100047 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/2175-8239-jbn-2019-0051 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Nefrologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Nefrologia |
dc.source.none.fl_str_mv |
Brazilian Journal of Nephrology v.42 n.1 2020 reponame:Jornal Brasileiro de Nefrologia instname:Sociedade Brasileira de Nefrologia (SBN) instacron:SBN |
instname_str |
Sociedade Brasileira de Nefrologia (SBN) |
instacron_str |
SBN |
institution |
SBN |
reponame_str |
Jornal Brasileiro de Nefrologia |
collection |
Jornal Brasileiro de Nefrologia |
repository.name.fl_str_mv |
Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN) |
repository.mail.fl_str_mv |
||jbn@sbn.org.br |
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1752122065715986432 |