Pro-angiogenic photo-crosslinked silk fibroin hydrogel: a potential candidate for repairing alveolar bone defects

Detalhes bibliográficos
Autor(a) principal: Ai, Yilong
Data de Publicação: 2023
Outros Autores: Wu, Siyuan, Zhou, Xuezhong
Tipo de documento: Conjunto de dados
Título da fonte: SciELO Data
Texto Completo: https://doi.org/10.48331/scielodata.YKRIKZ
Resumo: This study aimed to develop a pro-angiogenic hydrogel with in situ gelation ability for alveolar bone defects repair. Firstly, silk fibroin was chemically modified by Glycidyl Methacrylate (GMA) to obtain photo-crosslinkable silk fibroin. Next, scratch assay, transwell-based migration assay and angiogenic assay were conducted to investigate the effect of the photo-crosslinked silk fibroin hydrogel on the migration and tube formation behavior of human umbilical vein endothelial cells (HUVECs). Finally, subcutaneous implantation experiments were conducted to further examine the pro-angiogenic ability of the photo-crosslinked silk fibroin hydrogel. According to our results, it is concluded that the photo-crosslinked silk fibroin hydrogel possessed pro-angiogenic ability while inhibiting inflammation. Besides, the photo-crosslinking ability makes it suitable for matching irregular alveolar bone defects.
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spelling https://doi.org/10.48331/scielodata.YKRIKZAi, YilongWu, SiyuanZhou, XuezhongPro-angiogenic photo-crosslinked silk fibroin hydrogel: a potential candidate for repairing alveolar bone defectsSciELO DataThis study aimed to develop a pro-angiogenic hydrogel with in situ gelation ability for alveolar bone defects repair. Firstly, silk fibroin was chemically modified by Glycidyl Methacrylate (GMA) to obtain photo-crosslinkable silk fibroin. Next, scratch assay, transwell-based migration assay and angiogenic assay were conducted to investigate the effect of the photo-crosslinked silk fibroin hydrogel on the migration and tube formation behavior of human umbilical vein endothelial cells (HUVECs). Finally, subcutaneous implantation experiments were conducted to further examine the pro-angiogenic ability of the photo-crosslinked silk fibroin hydrogel. According to our results, it is concluded that the photo-crosslinked silk fibroin hydrogel possessed pro-angiogenic ability while inhibiting inflammation. Besides, the photo-crosslinking ability makes it suitable for matching irregular alveolar bone defects.2023-07-27info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0Medicine, Health and Life SciencesFibroinsHydrogelsNeovascularization, PhysiologicAlveolar Bone Lossinfo:eu-repo/semantics/datasetinfo:eu-repo/semantics/datasetinfo:eu-repo/semantics/publishedVersionDatasetreponame:SciELO Datainstname:Scientific Electronic Library Online (SCIELO)instacron:SCIRepositório de Dados de PesquisaONGhttps://data.scielo.org/oai/requestdata@scielo.orgopendoar:2024-04-11T06:12:59SciELO Data - Scientific Electronic Library Online (SCIELO)falsedoi:10.48331/scielodata.YKRIKZ
dc.title.none.fl_str_mv Pro-angiogenic photo-crosslinked silk fibroin hydrogel: a potential candidate for repairing alveolar bone defects
title Pro-angiogenic photo-crosslinked silk fibroin hydrogel: a potential candidate for repairing alveolar bone defects
spellingShingle Pro-angiogenic photo-crosslinked silk fibroin hydrogel: a potential candidate for repairing alveolar bone defects
Ai, Yilong
Medicine, Health and Life Sciences
Fibroins
Hydrogels
Neovascularization, Physiologic
Alveolar Bone Loss
title_short Pro-angiogenic photo-crosslinked silk fibroin hydrogel: a potential candidate for repairing alveolar bone defects
title_full Pro-angiogenic photo-crosslinked silk fibroin hydrogel: a potential candidate for repairing alveolar bone defects
title_fullStr Pro-angiogenic photo-crosslinked silk fibroin hydrogel: a potential candidate for repairing alveolar bone defects
title_full_unstemmed Pro-angiogenic photo-crosslinked silk fibroin hydrogel: a potential candidate for repairing alveolar bone defects
title_sort Pro-angiogenic photo-crosslinked silk fibroin hydrogel: a potential candidate for repairing alveolar bone defects
author Ai, Yilong
author_facet Ai, Yilong
Wu, Siyuan
Zhou, Xuezhong
author_role author
author2 Wu, Siyuan
Zhou, Xuezhong
author2_role author
author
dc.contributor.author.fl_str_mv Ai, Yilong
Wu, Siyuan
Zhou, Xuezhong
dc.subject.none.fl_str_mv Medicine, Health and Life Sciences
Fibroins
Hydrogels
Neovascularization, Physiologic
Alveolar Bone Loss
topic Medicine, Health and Life Sciences
Fibroins
Hydrogels
Neovascularization, Physiologic
Alveolar Bone Loss
description This study aimed to develop a pro-angiogenic hydrogel with in situ gelation ability for alveolar bone defects repair. Firstly, silk fibroin was chemically modified by Glycidyl Methacrylate (GMA) to obtain photo-crosslinkable silk fibroin. Next, scratch assay, transwell-based migration assay and angiogenic assay were conducted to investigate the effect of the photo-crosslinked silk fibroin hydrogel on the migration and tube formation behavior of human umbilical vein endothelial cells (HUVECs). Finally, subcutaneous implantation experiments were conducted to further examine the pro-angiogenic ability of the photo-crosslinked silk fibroin hydrogel. According to our results, it is concluded that the photo-crosslinked silk fibroin hydrogel possessed pro-angiogenic ability while inhibiting inflammation. Besides, the photo-crosslinking ability makes it suitable for matching irregular alveolar bone defects.
publishDate 2023
dc.date.issued.fl_str_mv 2023-07-27
dc.type.openaire.fl_str_mv info:eu-repo/semantics/dataset
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/dataset
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status_str publishedVersion
dc.identifier.url.fl_str_mv https://doi.org/10.48331/scielodata.YKRIKZ
url https://doi.org/10.48331/scielodata.YKRIKZ
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0
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dc.publisher.none.fl_str_mv SciELO Data
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repository.name.fl_str_mv SciELO Data - Scientific Electronic Library Online (SCIELO)
repository.mail.fl_str_mv data@scielo.org
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