Pro-angiogenic photo-crosslinked silk fibroin hydrogel: a potential candidate for repairing alveolar bone defects
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , |
Tipo de documento: | Conjunto de dados |
Título da fonte: | SciELO Data |
Texto Completo: | https://doi.org/10.48331/scielodata.YKRIKZ |
Resumo: | This study aimed to develop a pro-angiogenic hydrogel with in situ gelation ability for alveolar bone defects repair. Firstly, silk fibroin was chemically modified by Glycidyl Methacrylate (GMA) to obtain photo-crosslinkable silk fibroin. Next, scratch assay, transwell-based migration assay and angiogenic assay were conducted to investigate the effect of the photo-crosslinked silk fibroin hydrogel on the migration and tube formation behavior of human umbilical vein endothelial cells (HUVECs). Finally, subcutaneous implantation experiments were conducted to further examine the pro-angiogenic ability of the photo-crosslinked silk fibroin hydrogel. According to our results, it is concluded that the photo-crosslinked silk fibroin hydrogel possessed pro-angiogenic ability while inhibiting inflammation. Besides, the photo-crosslinking ability makes it suitable for matching irregular alveolar bone defects. |
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https://doi.org/10.48331/scielodata.YKRIKZAi, YilongWu, SiyuanZhou, XuezhongPro-angiogenic photo-crosslinked silk fibroin hydrogel: a potential candidate for repairing alveolar bone defectsSciELO DataThis study aimed to develop a pro-angiogenic hydrogel with in situ gelation ability for alveolar bone defects repair. Firstly, silk fibroin was chemically modified by Glycidyl Methacrylate (GMA) to obtain photo-crosslinkable silk fibroin. Next, scratch assay, transwell-based migration assay and angiogenic assay were conducted to investigate the effect of the photo-crosslinked silk fibroin hydrogel on the migration and tube formation behavior of human umbilical vein endothelial cells (HUVECs). Finally, subcutaneous implantation experiments were conducted to further examine the pro-angiogenic ability of the photo-crosslinked silk fibroin hydrogel. According to our results, it is concluded that the photo-crosslinked silk fibroin hydrogel possessed pro-angiogenic ability while inhibiting inflammation. Besides, the photo-crosslinking ability makes it suitable for matching irregular alveolar bone defects.2023-07-27info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0Medicine, Health and Life SciencesFibroinsHydrogelsNeovascularization, PhysiologicAlveolar Bone Lossinfo:eu-repo/semantics/datasetinfo:eu-repo/semantics/datasetinfo:eu-repo/semantics/publishedVersionDatasetreponame:SciELO Datainstname:Scientific Electronic Library Online (SCIELO)instacron:SCIRepositório de Dados de PesquisaONGhttps://data.scielo.org/oai/requestdata@scielo.orgopendoar:2024-04-11T06:12:59SciELO Data - Scientific Electronic Library Online (SCIELO)falsedoi:10.48331/scielodata.YKRIKZ |
dc.title.none.fl_str_mv |
Pro-angiogenic photo-crosslinked silk fibroin hydrogel: a potential candidate for repairing alveolar bone defects |
title |
Pro-angiogenic photo-crosslinked silk fibroin hydrogel: a potential candidate for repairing alveolar bone defects |
spellingShingle |
Pro-angiogenic photo-crosslinked silk fibroin hydrogel: a potential candidate for repairing alveolar bone defects Ai, Yilong Medicine, Health and Life Sciences Fibroins Hydrogels Neovascularization, Physiologic Alveolar Bone Loss |
title_short |
Pro-angiogenic photo-crosslinked silk fibroin hydrogel: a potential candidate for repairing alveolar bone defects |
title_full |
Pro-angiogenic photo-crosslinked silk fibroin hydrogel: a potential candidate for repairing alveolar bone defects |
title_fullStr |
Pro-angiogenic photo-crosslinked silk fibroin hydrogel: a potential candidate for repairing alveolar bone defects |
title_full_unstemmed |
Pro-angiogenic photo-crosslinked silk fibroin hydrogel: a potential candidate for repairing alveolar bone defects |
title_sort |
Pro-angiogenic photo-crosslinked silk fibroin hydrogel: a potential candidate for repairing alveolar bone defects |
author |
Ai, Yilong |
author_facet |
Ai, Yilong Wu, Siyuan Zhou, Xuezhong |
author_role |
author |
author2 |
Wu, Siyuan Zhou, Xuezhong |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Ai, Yilong Wu, Siyuan Zhou, Xuezhong |
dc.subject.none.fl_str_mv |
Medicine, Health and Life Sciences Fibroins Hydrogels Neovascularization, Physiologic Alveolar Bone Loss |
topic |
Medicine, Health and Life Sciences Fibroins Hydrogels Neovascularization, Physiologic Alveolar Bone Loss |
description |
This study aimed to develop a pro-angiogenic hydrogel with in situ gelation ability for alveolar bone defects repair. Firstly, silk fibroin was chemically modified by Glycidyl Methacrylate (GMA) to obtain photo-crosslinkable silk fibroin. Next, scratch assay, transwell-based migration assay and angiogenic assay were conducted to investigate the effect of the photo-crosslinked silk fibroin hydrogel on the migration and tube formation behavior of human umbilical vein endothelial cells (HUVECs). Finally, subcutaneous implantation experiments were conducted to further examine the pro-angiogenic ability of the photo-crosslinked silk fibroin hydrogel. According to our results, it is concluded that the photo-crosslinked silk fibroin hydrogel possessed pro-angiogenic ability while inhibiting inflammation. Besides, the photo-crosslinking ability makes it suitable for matching irregular alveolar bone defects. |
publishDate |
2023 |
dc.date.issued.fl_str_mv |
2023-07-27 |
dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/dataset |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.none.fl_str_mv |
info:eu-repo/semantics/dataset |
format |
dataset |
status_str |
publishedVersion |
dc.identifier.url.fl_str_mv |
https://doi.org/10.48331/scielodata.YKRIKZ |
url |
https://doi.org/10.48331/scielodata.YKRIKZ |
dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/4.0 |
dc.format.none.fl_str_mv |
Dataset |
dc.publisher.none.fl_str_mv |
SciELO Data |
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SciELO Data |
dc.source.none.fl_str_mv |
reponame:SciELO Data instname:Scientific Electronic Library Online (SCIELO) instacron:SCI |
instname_str |
Scientific Electronic Library Online (SCIELO) |
instacron_str |
SCI |
institution |
SCI |
reponame_str |
SciELO Data |
collection |
SciELO Data |
repository.name.fl_str_mv |
SciELO Data - Scientific Electronic Library Online (SCIELO) |
repository.mail.fl_str_mv |
data@scielo.org |
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1797042024758640640 |