Secondary metabolites and toxic potential of the crude hydroethanolic extract of mangaba leaves - Hancornia speciosa Gomes

Detalhes bibliográficos
Autor(a) principal: Souza Arraes, Alexandre
Data de Publicação: 2022
Outros Autores: Marques Junior, Jair, Alexandre Habitante, Carlos, Batalini, Claudemir
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Eletrônica Científica da Uergs
Texto Completo: https://revista.uergs.edu.br/index.php/revuergs/article/view/3342
Resumo: The use of medicinal plants dates from approximately 10 thousand years before Christ. The therapeutic potential of these plants justifies the performance of chemical analyzes to identify bioactive compounds responsible for the improvement of diseases. In this work, the phytochemistry of mangaba leaves (Hancornia speciosa Gomes) was investigated and its toxic potential was evaluated. The leaves of the plant were collected at Unit I of UFMT/CUA, in Pontal do Araguaia (MT) and the crude extract was obtained by maceration in 70% ethanolic solution. Phytochemical analysis of the crude dry extract obtained was performed using classical colorimetric chemical reactions. The investigation of the toxic potential was carried out against Artemia salina Leach larvae, at concentrations of 15 μg.mL-1, 50 μg.mL-1, 100 μg.mL-1, 500 μg.mL-1, 600 μg.mL-1 and 700 μg.mL-1. The phytochemical screening of secondary metabolites indicated a strong presence of catechins, steroids, phenols, flavanones, flavononols, saponins, tannins and catechetical tannins. It was also observed the absence of a series of other secondary metabolites. The analysis of the extract against A. salina larvae, at different concentrations, revealed toxicity (LC50 = 4035.1 μg.mL-1), raising good indications of a safe use of this extract for therapeutic purposes. The results indicate the presence of interesting secondary metabolites of the class of antioxidants that can present different biological activities, in which the research group is already investigating some, in the sense of searching for new drugs obtained from plants or fruits, especially from the region of Middle Araguaia.
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spelling Secondary metabolites and toxic potential of the crude hydroethanolic extract of mangaba leaves - Hancornia speciosa GomesMetabolitos secundarios y potencial tóxico del extracto hidroetanólico crudo de hojas de mangaba - Hancornia speciosa GomesMetabólitos secundários e potencial tóxico do extrato bruto hidroetanólico das folhas de mangaba - Hancornia speciosa GomesFitoquímica;planta medicinal;toxicidade.Fitoquímica;planta medicinal;toxicidad.Phytochemistry;medicinal plant;toxicity.The use of medicinal plants dates from approximately 10 thousand years before Christ. The therapeutic potential of these plants justifies the performance of chemical analyzes to identify bioactive compounds responsible for the improvement of diseases. In this work, the phytochemistry of mangaba leaves (Hancornia speciosa Gomes) was investigated and its toxic potential was evaluated. The leaves of the plant were collected at Unit I of UFMT/CUA, in Pontal do Araguaia (MT) and the crude extract was obtained by maceration in 70% ethanolic solution. Phytochemical analysis of the crude dry extract obtained was performed using classical colorimetric chemical reactions. The investigation of the toxic potential was carried out against Artemia salina Leach larvae, at concentrations of 15 μg.mL-1, 50 μg.mL-1, 100 μg.mL-1, 500 μg.mL-1, 600 μg.mL-1 and 700 μg.mL-1. The phytochemical screening of secondary metabolites indicated a strong presence of catechins, steroids, phenols, flavanones, flavononols, saponins, tannins and catechetical tannins. It was also observed the absence of a series of other secondary metabolites. The analysis of the extract against A. salina larvae, at different concentrations, revealed toxicity (LC50 = 4035.1 μg.mL-1), raising good indications of a safe use of this extract for therapeutic purposes. The results indicate the presence of interesting secondary metabolites of the class of antioxidants that can present different biological activities, in which the research group is already investigating some, in the sense of searching for new drugs obtained from plants or fruits, especially from the region of Middle Araguaia.O uso de plantas medicinais data de aproximadamente 10 mil anos antes de Cristo. O potencial terapêutico dessas plantas justifica a realização de análises químicas para identificar compostos bioativos responsáveis pela melhora de enfermidades. Investigou-se, neste trabalho, a fitoquímica das folhas de mangaba (Hancornia speciosa Gomes) e avaliou-se seu potencial tóxico. As folhas da planta foram coletadas na Unidade I da UFMT/CUA, em Pontal do Araguaia (MT), e o extrato bruto obtido por maceração em solução etanólica a 70%. A análise fitoquímica do extrato bruto seco obtido foi realizada através de reações químicas clássicas colorimétricas. A investigação do potencial tóxico se deu frente às larvas de Artemia salina Leach, nas concentrações de 15 μg.mL-1, 50 μg.mL-1, 100 μg.mL-1, 500 μg.mL-1, 600 μg.mL-1 e 700 μg.mL-1. A triagem fitoquímica dos metabólitos secundários sinalizou forte presença de catequinas, esteroides, fenóis, flavanonas, flavononóis, saponinas, taninos e taninos catéquicos. Observou-se ainda ausência de uma série de outros metabólitos secundários. A análise do extrato frente às larvas de A. salina, nas diferentes concentrações, revelou atoxicidade (CL50 = 4035,1 μg.mL-1), levantando bons indícios de uma segura utilização desse extrato para fins terapêuticos. Os resultados indicam a presença de metabólitos secundários interessantes da classe dos antioxidantes que podem apresentar diferentes atividades biológicas, sendo que o grupo de pesquisa já se encontra investigando alguns, no sentido da busca de novos fármacos obtidos através de plantas ou frutos, especialmente da região do Médio Araguaia.  Palavras-chave: Fitoquímica; planta medicinal; toxicidade.    Abstract  Secondary metabolites and toxic potential of the crude hydroethanolic extract of mangaba leaves - Hancornia speciosa Gomes  The use of medicinal plants dates from approximately 10 thousand years before Christ. The therapeutic potential of these plants justifies the performance of chemical analyzes to identify bioactive compounds responsible for the improvement of diseases. In this work, the phytochemistry of mangaba leaves (Hancornia speciosa Gomes) was investigated and its toxic potential was evaluated. The leaves of the plant were collected at Unit I of UFMT/CUA, in Pontal do Araguaia (MT) and the crude extract was obtained by maceration in 70% ethanolic solution. Phytochemical analysis of the crude dry extract obtained was performed using classical colorimetric chemical reactions. The investigation of the toxic potential was carried out against Artemia salina Leach larvae, at concentrations of 15 μg.mL-1, 50 μg.mL-1, 100 μg.mL-1, 500 μg.mL-1, 600 μg.mL-1 and 700 μg.mL-1. The phytochemical screening of secondary metabolites indicated a strong presence of catechins, steroids, phenols, flavanones, flavononols, saponins, tannins and catechetical tannins. It was also observed the absence of a series of other secondary metabolites. The analysis of the extract against A. salina larvae, at different concentrations, revealed toxicity (LC50 = 4035.1 μg.mL-1), raising good indications of a safe use of this extract for therapeutic purposes. The results indicate the presence of interesting secondary metabolites of the class of antioxidants that can present different biological activities, in which the research group is already investigating some, in the sense of searching for new drugs obtained from plants or fruits, especially from the region of Middle Araguaia.   Keywords: Phytochemistry; medicinal plant; toxicity.   Resumen  Metabolitos secundarios y potencial tóxico del extracto hidroetanólico crudo de hojas de mangaba - Hancornia speciosa Gomes  El uso de las plantas medicinales data aproximadamente de 10 mil años antes de Cristo. El potencial terapéutico de estas plantas justifica la realización de análisis químicos para identificar compuestos bioactivos responsables de la mejora de enfermedades. En este trabajo se investigó la fitoquímica de las hojas de mangaba (Hancornia speciosa Gomes) y se evaluó su potencial tóxico. Las hojas de la planta fueron recolectadas en la Unidad I de la UFMT/CUA, en Pontal do Araguaia (MT), y el extracto crudo fue obtenido por maceración en solución etanólica al 70%. El análisis fitoquímico del extracto seco crudo obtenido se realizó mediante reacciones químicas colorimétricas clásicas. La investigación del potencial tóxico se realizó en larvas de Artemia salina Leach, en concentraciones de 15 μg.mL-1, 50 μg.mL-1, 100 μg.mL-1, 500 μg.mL-1, 600 μg.mL-1 y 700 μg.mL-1. El tamizaje fitoquímico de metabolitos secundarios indicó una fuerte presencia de catequinas, esteroides, fenoles, flavanonas, flavononoles, saponinas, taninos y taninos de catequinas. También se observó la ausencia de una serie de otros metabolitos secundarios. El análisis del extracto en larvas de A. salina, a diferentes concentraciones, no reveló toxicidad (CL50 = 4035,1 μg.mL-1), lo que plantea buenos indicios de un uso seguro de este extracto con fines terapéuticos. Los resultados indican la presencia de interesantes metabolitos secundarios de la clase de los antioxidantes que pueden presentar diferentes actividades biológicas, siendo que el grupo de investigación ya investiga algunos, en el sentido de buscar nuevos fármacos obtenidos de plantas o frutos, especialmente de la región de Medio Araguaia.   Palabras clave: Fitoquímica; planta medicinal; toxicidad.Uergs2022-08-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revista.uergs.edu.br/index.php/revuergs/article/view/334210.21674/2448-0479.82.150-157Revista Eletrônica Científica da UERGS ; v. 8 n. 2 (2022): Agosto; 150-1572448-0479reponame:Revista Eletrônica Científica da Uergsinstname:Universidade Estadual do Rio Grande do Sul (UERGS)instacron:UERGSporhttps://revista.uergs.edu.br/index.php/revuergs/article/view/3342/553Copyright (c) 2022 Alexandre Souza Arraes, Jair Marques Junior, Carlos Alexandre Habitante, Claudemir Bataliniinfo:eu-repo/semantics/openAccessSouza Arraes, AlexandreMarques Junior, Jair Alexandre Habitante, CarlosBatalini, Claudemir2022-09-01T18:09:54Zoai:ojs.pkp.sfu.ca:article/3342Revistahttp://revista.uergs.edu.br/index.php/revuergs/indexPUBhttp://revista.uergs.edu.br/index.php/revuergs/oai||revista@uergs.edu.br2448-04792448-0479opendoar:2022-09-01T18:09:54Revista Eletrônica Científica da Uergs - Universidade Estadual do Rio Grande do Sul (UERGS)false
dc.title.none.fl_str_mv Secondary metabolites and toxic potential of the crude hydroethanolic extract of mangaba leaves - Hancornia speciosa Gomes
Metabolitos secundarios y potencial tóxico del extracto hidroetanólico crudo de hojas de mangaba - Hancornia speciosa Gomes
Metabólitos secundários e potencial tóxico do extrato bruto hidroetanólico das folhas de mangaba - Hancornia speciosa Gomes
title Secondary metabolites and toxic potential of the crude hydroethanolic extract of mangaba leaves - Hancornia speciosa Gomes
spellingShingle Secondary metabolites and toxic potential of the crude hydroethanolic extract of mangaba leaves - Hancornia speciosa Gomes
Souza Arraes, Alexandre
Fitoquímica;
planta medicinal;
toxicidade.
Fitoquímica;
planta medicinal;
toxicidad.
Phytochemistry;
medicinal plant;
toxicity.
title_short Secondary metabolites and toxic potential of the crude hydroethanolic extract of mangaba leaves - Hancornia speciosa Gomes
title_full Secondary metabolites and toxic potential of the crude hydroethanolic extract of mangaba leaves - Hancornia speciosa Gomes
title_fullStr Secondary metabolites and toxic potential of the crude hydroethanolic extract of mangaba leaves - Hancornia speciosa Gomes
title_full_unstemmed Secondary metabolites and toxic potential of the crude hydroethanolic extract of mangaba leaves - Hancornia speciosa Gomes
title_sort Secondary metabolites and toxic potential of the crude hydroethanolic extract of mangaba leaves - Hancornia speciosa Gomes
author Souza Arraes, Alexandre
author_facet Souza Arraes, Alexandre
Marques Junior, Jair
Alexandre Habitante, Carlos
Batalini, Claudemir
author_role author
author2 Marques Junior, Jair
Alexandre Habitante, Carlos
Batalini, Claudemir
author2_role author
author
author
dc.contributor.author.fl_str_mv Souza Arraes, Alexandre
Marques Junior, Jair
Alexandre Habitante, Carlos
Batalini, Claudemir
dc.subject.por.fl_str_mv Fitoquímica;
planta medicinal;
toxicidade.
Fitoquímica;
planta medicinal;
toxicidad.
Phytochemistry;
medicinal plant;
toxicity.
topic Fitoquímica;
planta medicinal;
toxicidade.
Fitoquímica;
planta medicinal;
toxicidad.
Phytochemistry;
medicinal plant;
toxicity.
description The use of medicinal plants dates from approximately 10 thousand years before Christ. The therapeutic potential of these plants justifies the performance of chemical analyzes to identify bioactive compounds responsible for the improvement of diseases. In this work, the phytochemistry of mangaba leaves (Hancornia speciosa Gomes) was investigated and its toxic potential was evaluated. The leaves of the plant were collected at Unit I of UFMT/CUA, in Pontal do Araguaia (MT) and the crude extract was obtained by maceration in 70% ethanolic solution. Phytochemical analysis of the crude dry extract obtained was performed using classical colorimetric chemical reactions. The investigation of the toxic potential was carried out against Artemia salina Leach larvae, at concentrations of 15 μg.mL-1, 50 μg.mL-1, 100 μg.mL-1, 500 μg.mL-1, 600 μg.mL-1 and 700 μg.mL-1. The phytochemical screening of secondary metabolites indicated a strong presence of catechins, steroids, phenols, flavanones, flavononols, saponins, tannins and catechetical tannins. It was also observed the absence of a series of other secondary metabolites. The analysis of the extract against A. salina larvae, at different concentrations, revealed toxicity (LC50 = 4035.1 μg.mL-1), raising good indications of a safe use of this extract for therapeutic purposes. The results indicate the presence of interesting secondary metabolites of the class of antioxidants that can present different biological activities, in which the research group is already investigating some, in the sense of searching for new drugs obtained from plants or fruits, especially from the region of Middle Araguaia.
publishDate 2022
dc.date.none.fl_str_mv 2022-08-31
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revista.uergs.edu.br/index.php/revuergs/article/view/3342
10.21674/2448-0479.82.150-157
url https://revista.uergs.edu.br/index.php/revuergs/article/view/3342
identifier_str_mv 10.21674/2448-0479.82.150-157
dc.language.iso.fl_str_mv por
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dc.relation.none.fl_str_mv https://revista.uergs.edu.br/index.php/revuergs/article/view/3342/553
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Uergs
publisher.none.fl_str_mv Uergs
dc.source.none.fl_str_mv Revista Eletrônica Científica da UERGS ; v. 8 n. 2 (2022): Agosto; 150-157
2448-0479
reponame:Revista Eletrônica Científica da Uergs
instname:Universidade Estadual do Rio Grande do Sul (UERGS)
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instname_str Universidade Estadual do Rio Grande do Sul (UERGS)
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reponame_str Revista Eletrônica Científica da Uergs
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