Clinical and immunological features of patients with atopy and concomitant HTLV-1 infection
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/6920 |
Resumo: | p. 1168/1172 |
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Gaspar-Sobrinho, Fernando PenaMachado, Adelmir de SouzaSantos, S. B.Orge, G.Lessa, Hélio AndradeCruz Filho, Álvaro Augusto Souza daCarvalho Filho, Edgar Marcelino deGaspar-Sobrinho, Fernando PenaMachado, Adelmir de SouzaSantos, S. B.Orge, G.Lessa, Hélio AndradeCruz Filho, Álvaro Augusto Souza daCarvalho Filho, Edgar Marcelino de2012-10-09T20:42:38Z2012-10-09T20:42:38Z20100100-879Xhttp://www.repositorio.ufba.br/ri/handle/ri/6920v. 43p. 1168/1172Human T-cell lymphotropic virus type 1 (HTLV-1) induces an exacerbated type 1 immune response characterized by high spontaneous IFN-γ and TNF-α production. Allergic rhinitis and asthma are associated with the type 2 immune response, with elevated secretion of IL-4 and IL-5. The aim of this study was to characterize the immune response in atopic HTLV-1 carriers. The cytokine profile of atopic HTLV-1 carriers (N = 10; all females) was compared with that of non-atopic HTLV-1 carriers (N = 14; 9 females and 5 males). Mean patient age of atopic and non-atopic groups was 45 ± 8 and 38 ± 11 years, respectively. All atopic HTLV-1 carriers had rhinitis with or without asthma and a skin prick test positive for Dermatophagoides pteronyssinus antigen 1 (Derp-1). There was no difference in cytokine levels between the two groups in unstimulated peripheral blood mononuclear cell cultures. In cultures stimulated with Derp-1, IFN-γ levels tended to be higher (P = 0.06) and IL-5 levels were higher (P = 0.02) in atopic HTLV-1 patients than in non-atopic subjects. In contrast, IL-10 was lower (P = 0.004) in atopic than in non-atopic HTLV-1-infected subjects. This study shows that HTLV-1 infection with an exaggerated type 1 immune response does not prevent atopy. In this case, the exacerbated type 1 and type 2 immune responses were due to a lack of IL-10 production, a cytokine that plays an important role in down-modulating type 1 and type 2 immune responses and in preventing the development of chronic inflammatory diseases.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2012-10-09T20:42:38Z No. of bitstreams: 1 Gaspar-Sobrinho, F.P..pdf: 528462 bytes, checksum: 96df9ab4a40ba85d5d80d46a7b9a2ccb (MD5)Made available in DSpace on 2012-10-09T20:42:38Z (GMT). No. of bitstreams: 1 Gaspar-Sobrinho, F.P..pdf: 528462 bytes, checksum: 96df9ab4a40ba85d5d80d46a7b9a2ccb (MD5) Previous issue date: 2010SalvadorBrazilian Journal of Medical and Biological Research10.1590/S0100-879X2010007500138reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAAsthmaAtopyCytokinesHTLV-1RhinitisClinical and immunological features of patients with atopy and concomitant HTLV-1 infectionBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/6920/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52ORIGINALGaspar-Sobrinho, F.P..pdfGaspar-Sobrinho, F.P..pdfapplication/pdf528462https://repositorio.ufba.br/bitstream/ri/6920/1/Gaspar-Sobrinho%2c%20F.P..pdf96df9ab4a40ba85d5d80d46a7b9a2ccbMD51TEXTGaspar-Sobrinho, F.P..pdf.txtGaspar-Sobrinho, F.P..pdf.txtExtracted texttext/plain26726https://repositorio.ufba.br/bitstream/ri/6920/3/Gaspar-Sobrinho%2c%20F.P..pdf.txtb731c3e058f4d57ef77d4cf0496a43cfMD53ri/69202022-07-05 14:02:54.872oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:54Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Clinical and immunological features of patients with atopy and concomitant HTLV-1 infection |
| dc.title.alternative.pt_BR.fl_str_mv |
Brazilian Journal of Medical and Biological Research |
| title |
Clinical and immunological features of patients with atopy and concomitant HTLV-1 infection |
| spellingShingle |
Clinical and immunological features of patients with atopy and concomitant HTLV-1 infection Gaspar-Sobrinho, Fernando Pena Asthma Atopy Cytokines HTLV-1 Rhinitis |
| title_short |
Clinical and immunological features of patients with atopy and concomitant HTLV-1 infection |
| title_full |
Clinical and immunological features of patients with atopy and concomitant HTLV-1 infection |
| title_fullStr |
Clinical and immunological features of patients with atopy and concomitant HTLV-1 infection |
| title_full_unstemmed |
Clinical and immunological features of patients with atopy and concomitant HTLV-1 infection |
| title_sort |
Clinical and immunological features of patients with atopy and concomitant HTLV-1 infection |
| author |
Gaspar-Sobrinho, Fernando Pena |
| author_facet |
Gaspar-Sobrinho, Fernando Pena Machado, Adelmir de Souza Santos, S. B. Orge, G. Lessa, Hélio Andrade Cruz Filho, Álvaro Augusto Souza da Carvalho Filho, Edgar Marcelino de |
| author_role |
author |
| author2 |
Machado, Adelmir de Souza Santos, S. B. Orge, G. Lessa, Hélio Andrade Cruz Filho, Álvaro Augusto Souza da Carvalho Filho, Edgar Marcelino de |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Gaspar-Sobrinho, Fernando Pena Machado, Adelmir de Souza Santos, S. B. Orge, G. Lessa, Hélio Andrade Cruz Filho, Álvaro Augusto Souza da Carvalho Filho, Edgar Marcelino de Gaspar-Sobrinho, Fernando Pena Machado, Adelmir de Souza Santos, S. B. Orge, G. Lessa, Hélio Andrade Cruz Filho, Álvaro Augusto Souza da Carvalho Filho, Edgar Marcelino de |
| dc.subject.por.fl_str_mv |
Asthma Atopy Cytokines HTLV-1 Rhinitis |
| topic |
Asthma Atopy Cytokines HTLV-1 Rhinitis |
| description |
p. 1168/1172 |
| publishDate |
2010 |
| dc.date.issued.fl_str_mv |
2010 |
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2012-10-09T20:42:38Z |
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2012-10-09T20:42:38Z |
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info:eu-repo/semantics/publishedVersion |
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0100-879X |
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v. 43 |
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0100-879X v. 43 |
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Brazilian Journal of Medical and Biological Research |
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Brazilian Journal of Medical and Biological Research |
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10.1590/S0100-879X2010007500138 |
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