Nitric Oxide Plasma/Serum Levels In Patients With Schizophrenia: A Systematic Review And Meta-Analysis

Detalhes bibliográficos
Autor(a) principal: Iego, Sandro
Data de Publicação: 2012
Outros Autores: Oliveira, João Paulo Maia de, Trzesniak, Clarissa, Oliveira, Irismar R., Kempton, Matthew J., Rezende, Tatiana M. N. de, Baker, Glen B., Dursun, Serdar M., Sousa, João Paulo Machado de, Hallak, Jaime E. C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/15325
Resumo: p. 149-162
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spelling Iego, SandroOliveira, João Paulo Maia deTrzesniak, ClarissaOliveira, Irismar R.Kempton, Matthew J.Rezende, Tatiana M. N. deBaker, Glen B.Dursun, Serdar M.Sousa, João Paulo Machado deHallak, Jaime E. C.2014-07-28T19:30:15Z2014-07-28T19:30:15Z20121516-4446http://repositorio.ufba.br/ri/handle/ri/15325v. 34, n. 2p. 149-162For the last 40 years, schizophrenia has been considered to be the result primarily of a dysfunction in brain dopaminergic pathways. In this review, it is described and discussed findings concerning nitric oxide-mediated neurotransmission in schizophrenia. Studies were searched in PubMed, SciELO, and LILACS using the terms schizophrenia and nitric oxide plasma levels or nitric oxide serum levels, with no time limit. The reference lists of selected articles were also hand-searched for additional articles. From 15 potential reports, 10 were eligible to be included in the review and meta-analysis. These studies included a total of 505 patients with schizophrenia and 339 healthy volunteers. No significant difference was found between patients and healthy controls regarding total nitrite plasma/serum levels (effect size g = 0.285, 95%CI = -0.205 to 0.774, p = 0.254). However, when studies with patients under antipsychotic treatment were examined separately, there was a significant difference between patients and healthy volunteers (effect size g = 0.663, 95%CI = 0.365 to 0.961, p < 0.001), showing that patients under treatment have higher levels of plasma/serum nitric oxide than controls. These results suggest that antipsychotics increase nitric oxide plasma/serum levels and that the nitrergic pathway would be a fertile target for the development of new treatments for patients with schizophrenia.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-06-10T13:19:27Z No. of bitstreams: 1 Sandro Iego.pdf: 1138266 bytes, checksum: 5a67ec6afc408f26b777706afbcb100d (MD5)Approved for entry into archive by Oliveira Santos Dilzaná (dilznana@yahoo.com.br) on 2014-07-28T19:30:15Z (GMT) No. of bitstreams: 1 Sandro Iego.pdf: 1138266 bytes, checksum: 5a67ec6afc408f26b777706afbcb100d (MD5)Made available in DSpace on 2014-07-28T19:30:15Z (GMT). No. of bitstreams: 1 Sandro Iego.pdf: 1138266 bytes, checksum: 5a67ec6afc408f26b777706afbcb100d (MD5) Previous issue date: 2012http://dx.doi.org/ 10.1016/j.rbp.2012.07.001reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBANitric Oxide Plasma/Serum Levels In Patients With Schizophrenia: A Systematic Review And Meta-AnalysisRevista Brasileira de Psiquiatriainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBrasilinfo:eu-repo/semantics/openAccessengORIGINALSandro Iego.pdfSandro Iego.pdfapplication/pdf1138266https://repositorio.ufba.br/bitstream/ri/15325/1/Sandro%20Iego.pdf5a67ec6afc408f26b777706afbcb100dMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/15325/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52TEXTSandro Iego.pdf.txtSandro Iego.pdf.txtExtracted texttext/plain57541https://repositorio.ufba.br/bitstream/ri/15325/3/Sandro%20Iego.pdf.txt7cfffad66959d41e7a4d568726e7c5e3MD53ri/153252022-03-09 20:30:12.63oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-03-09T23:30:12Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Nitric Oxide Plasma/Serum Levels In Patients With Schizophrenia: A Systematic Review And Meta-Analysis
dc.title.alternative.pt_BR.fl_str_mv Revista Brasileira de Psiquiatria
title Nitric Oxide Plasma/Serum Levels In Patients With Schizophrenia: A Systematic Review And Meta-Analysis
spellingShingle Nitric Oxide Plasma/Serum Levels In Patients With Schizophrenia: A Systematic Review And Meta-Analysis
Iego, Sandro
title_short Nitric Oxide Plasma/Serum Levels In Patients With Schizophrenia: A Systematic Review And Meta-Analysis
title_full Nitric Oxide Plasma/Serum Levels In Patients With Schizophrenia: A Systematic Review And Meta-Analysis
title_fullStr Nitric Oxide Plasma/Serum Levels In Patients With Schizophrenia: A Systematic Review And Meta-Analysis
title_full_unstemmed Nitric Oxide Plasma/Serum Levels In Patients With Schizophrenia: A Systematic Review And Meta-Analysis
title_sort Nitric Oxide Plasma/Serum Levels In Patients With Schizophrenia: A Systematic Review And Meta-Analysis
author Iego, Sandro
author_facet Iego, Sandro
Oliveira, João Paulo Maia de
Trzesniak, Clarissa
Oliveira, Irismar R.
Kempton, Matthew J.
Rezende, Tatiana M. N. de
Baker, Glen B.
Dursun, Serdar M.
Sousa, João Paulo Machado de
Hallak, Jaime E. C.
author_role author
author2 Oliveira, João Paulo Maia de
Trzesniak, Clarissa
Oliveira, Irismar R.
Kempton, Matthew J.
Rezende, Tatiana M. N. de
Baker, Glen B.
Dursun, Serdar M.
Sousa, João Paulo Machado de
Hallak, Jaime E. C.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Iego, Sandro
Oliveira, João Paulo Maia de
Trzesniak, Clarissa
Oliveira, Irismar R.
Kempton, Matthew J.
Rezende, Tatiana M. N. de
Baker, Glen B.
Dursun, Serdar M.
Sousa, João Paulo Machado de
Hallak, Jaime E. C.
description p. 149-162
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-07-28T19:30:15Z
dc.date.available.fl_str_mv 2014-07-28T19:30:15Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/15325
dc.identifier.issn.none.fl_str_mv 1516-4446
dc.identifier.number.pt_BR.fl_str_mv v. 34, n. 2
identifier_str_mv 1516-4446
v. 34, n. 2
url http://repositorio.ufba.br/ri/handle/ri/15325
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.country.fl_str_mv Brasil
dc.source.pt_BR.fl_str_mv http://dx.doi.org/ 10.1016/j.rbp.2012.07.001
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