Central 5-HT3 receptors and water intake in rats

Detalhes bibliográficos
Autor(a) principal: Castro, Letícia
Data de Publicação: 2002
Outros Autores: Varjão, Bruno, Maldonado, Igor, Campos, Igor, Duque, Bruno, Fregoneze, Josmara, Oliveira, Irismar Reis de, Silva, Emı́lio de Castro e
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/7456
Resumo: Texto completo: acesso restrito. p. 349-359
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spelling Castro, LetíciaVarjão, BrunoMaldonado, IgorCampos, IgorDuque, BrunoFregoneze, JosmaraOliveira, Irismar Reis deSilva, Emı́lio de Castro eCastro, LetíciaVarjão, BrunoMaldonado, IgorCampos, IgorDuque, BrunoFregoneze, JosmaraOliveira, Irismar Reis deSilva, Emı́lio de Castro e2012-12-12T14:48:09Z2002-110031-9384http://www.repositorio.ufba.br/ri/handle/ri/7456v. 77, n. 2-3Texto completo: acesso restrito. p. 349-359In the present paper, we studied in rats the effect of third ventricle administration of m-chlorophenylbiguanide hydrochloride (1-(3-chlorophenyl)biguanide (m-CPBG), a selective 5-HT3 agonist, on water intake induced by three different physiological stimuli: water deprivation, acute salt load and hypovolemia. Central acute m-CPBG injections in the doses of 80 and 160 nmol significantly reduced water intake elicited by an acute salt load. Third ventricle injections of m-CPBG in the dose of 160 nmol significantly inhibited water intake in hypovolemic animals, whereas third ventricle injections of m-CPBG in a higher dose (320 nmol) were necessary to decrease water intake in water-deprived rats. Pretreatment with 1-methyl-N-[8-methyl 8-azabicyclo(3.2.1)-oct-3-yl]-1H-indazole-3-carboxamide (LY-278,584), a selective 5-HT3 antagonist, abolished the inhibitory effect on water intake seen after central administration of m-CPBG in all groups studied. The central administration of m-CPBG was also able to inhibit water intake induced by pharmacological activation of central cholinergic and angiotensinergic pathways. Third ventricle injections of m-CPBG in the highest dose employed in this study (320 nmol) were unable to modify food intake in food-deprived rats. An aversion test has shown that acute third ventricle injections of m-CPBG do not induce illness-like effects that could explain the water intake inhibition here observed. Also, central administration of m-CPBG did not modify the intake of a “dessert” meal consisting of diluted condensed milk. It is concluded that central 5-HT3 receptor activation exerts a specific inhibitory effect on water intake.Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2012-12-12T14:48:09Z No. of bitstreams: 1 1-s2.0-S0031938402008727-main.pdf: 268735 bytes, checksum: 6a4ba32525f9591de29195d24b6ec41e (MD5)Made available in DSpace on 2012-12-12T14:48:09Z (GMT). No. of bitstreams: 1 1-s2.0-S0031938402008727-main.pdf: 268735 bytes, checksum: 6a4ba32525f9591de29195d24b6ec41e (MD5) Previous issue date: 2002-11http://dx.doi.org/10.1016/S0031-9384(02)00872-7reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBA5-HT3 receptorsDrinking behaviorWater intakeThirst; HypovolemiaHyperosmolarityFluid deprivationSerotoninm-CPBGCentral 5-HT3 receptors and water intake in ratsPhysiology and Behaviorinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL1-s2.0-S0031938402008727-main.pdf1-s2.0-S0031938402008727-main.pdfapplication/pdf268735https://repositorio.ufba.br/bitstream/ri/7456/1/1-s2.0-S0031938402008727-main.pdf6a4ba32525f9591de29195d24b6ec41eMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/7456/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT1-s2.0-S0031938402008727-main.pdf.txt1-s2.0-S0031938402008727-main.pdf.txtExtracted texttext/plain55882https://repositorio.ufba.br/bitstream/ri/7456/3/1-s2.0-S0031938402008727-main.pdf.txtb788d49333c89ea64c5dfbf1f15ebf6eMD53ri/74562022-07-05 14:03:45.92oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:45Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Central 5-HT3 receptors and water intake in rats
dc.title.alternative.pt_BR.fl_str_mv Physiology and Behavior
title Central 5-HT3 receptors and water intake in rats
spellingShingle Central 5-HT3 receptors and water intake in rats
Castro, Letícia
5-HT3 receptors
Drinking behavior
Water intake
Thirst; Hypovolemia
Hyperosmolarity
Fluid deprivation
Serotonin
m-CPBG
title_short Central 5-HT3 receptors and water intake in rats
title_full Central 5-HT3 receptors and water intake in rats
title_fullStr Central 5-HT3 receptors and water intake in rats
title_full_unstemmed Central 5-HT3 receptors and water intake in rats
title_sort Central 5-HT3 receptors and water intake in rats
author Castro, Letícia
author_facet Castro, Letícia
Varjão, Bruno
Maldonado, Igor
Campos, Igor
Duque, Bruno
Fregoneze, Josmara
Oliveira, Irismar Reis de
Silva, Emı́lio de Castro e
author_role author
author2 Varjão, Bruno
Maldonado, Igor
Campos, Igor
Duque, Bruno
Fregoneze, Josmara
Oliveira, Irismar Reis de
Silva, Emı́lio de Castro e
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Castro, Letícia
Varjão, Bruno
Maldonado, Igor
Campos, Igor
Duque, Bruno
Fregoneze, Josmara
Oliveira, Irismar Reis de
Silva, Emı́lio de Castro e
Castro, Letícia
Varjão, Bruno
Maldonado, Igor
Campos, Igor
Duque, Bruno
Fregoneze, Josmara
Oliveira, Irismar Reis de
Silva, Emı́lio de Castro e
dc.subject.por.fl_str_mv 5-HT3 receptors
Drinking behavior
Water intake
Thirst; Hypovolemia
Hyperosmolarity
Fluid deprivation
Serotonin
m-CPBG
topic 5-HT3 receptors
Drinking behavior
Water intake
Thirst; Hypovolemia
Hyperosmolarity
Fluid deprivation
Serotonin
m-CPBG
description Texto completo: acesso restrito. p. 349-359
publishDate 2002
dc.date.issued.fl_str_mv 2002-11
dc.date.accessioned.fl_str_mv 2012-12-12T14:48:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7456
dc.identifier.issn.none.fl_str_mv 0031-9384
dc.identifier.number.pt_BR.fl_str_mv v. 77, n. 2-3
identifier_str_mv 0031-9384
v. 77, n. 2-3
url http://www.repositorio.ufba.br/ri/handle/ri/7456
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/S0031-9384(02)00872-7
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
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collection Repositório Institucional da UFBA
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