T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice

Detalhes bibliográficos
Autor(a) principal: Pompeu, Margarida
Data de Publicação: 1992
Outros Autores: Freitas, A. L, Reis, G. A. dos, Barral Netto, Manoel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/26380
Resumo: Barral Netto, Manoel. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Pompeu, MargaridaFreitas, A. LReis, G. A. dosBarral Netto, Manoel2018-05-10T14:25:32Z2018-05-10T14:25:32Z1992POMPEU, M. et al. T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice. Parasitology Research, v. 78, p. 16-22, 1992.0932-0113https://www.arca.fiocruz.br/handle/icict/26380Barral Netto, Manoel. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.US-PHS (grant AI 16-282-11), the Brazilian National Research Council (CNPq) and the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases.Universidade Federal da Bahia. Faculdade de Medicina. Hospital Universitário Professor Edgard Santos. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Medicina. Hospital Universitário Professor Edgard Santos. Salvador, BA, BrasilUniversidade Feederal do Rio de Janeiro. Instituto de Microbiologia. Rio de Janeiro, RJ, BrasilUniversidade Federal da Bahia. Faculdade de Medicina. Hospital Universitário Professor Edgard Santos. Salvador, BA, BrasilAbstract. Highly susceptible naive BALB/c mice or mice that had previously been immunized i.v. with solubilized homologous antigen (partially resistant) were infected with Leishmania amazonensis. Histologically, the main differences between the two groups were lymphocytic infiltration and macrophage activation. Assays of T-cell function at 3 and 10 weeks after infection revealed that purified T-cells did not proliferate following treatment with leishmania antigen. A mitogenic anti-CD3 monoclonal antibody (mAb) failed to activate T-cells after 3 weeks of infection as judged by proliferation and IL-2 secretion assays. After 10 weeks of infection, anti-CD3 mAb fully activated T-cells to proliferation and IL-2 secretion. On the other hand, T-cells released IL-3 in response to leishmania antigen, anti-CD3 mAb and anti- Thyl mAb at 3 and 10 weeks post-infection. Surprisingly, a mitogenic anti-Thy 1 mAb (G7) fully activated Tcells even at 3 weeks of infection as judged by proliferative and IL-2 secretion assays. No significant differences were found in the proliferative or interleukin secretory responses of T-cells from animals that had been infected in either the presence or the absence of prior immunization. Since the Thyl triggering pathway has different accessory cell and cytokine requirements than does the CD3 : TCR lymphocyte activation pathway, it is possible that immunization was more effective in changing the cellular interactions of the T-lymphocyte than in altering its intrinsic capabilities.engSpringer VerlagLeishmania amazonensisLinfócitos TInfecçãoAnimaisCamundongosLeishmania amazonensisT-lymphocytesInfectionAnimalsMiceT-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/26380/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPompeu ML T-lymphocytes in experimental Leishmania amazonensis.pdfPompeu ML 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dc.title.pt_BR.fl_str_mv T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice
title T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice
spellingShingle T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice
Pompeu, Margarida
Leishmania amazonensis
Linfócitos T
Infecção
Animais
Camundongos
Leishmania amazonensis
T-lymphocytes
Infection
Animals
Mice
title_short T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice
title_full T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice
title_fullStr T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice
title_full_unstemmed T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice
title_sort T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice
author Pompeu, Margarida
author_facet Pompeu, Margarida
Freitas, A. L
Reis, G. A. dos
Barral Netto, Manoel
author_role author
author2 Freitas, A. L
Reis, G. A. dos
Barral Netto, Manoel
author2_role author
author
author
dc.contributor.author.fl_str_mv Pompeu, Margarida
Freitas, A. L
Reis, G. A. dos
Barral Netto, Manoel
dc.subject.other.pt_BR.fl_str_mv Leishmania amazonensis
Linfócitos T
Infecção
Animais
Camundongos
topic Leishmania amazonensis
Linfócitos T
Infecção
Animais
Camundongos
Leishmania amazonensis
T-lymphocytes
Infection
Animals
Mice
dc.subject.en.pt_BR.fl_str_mv Leishmania amazonensis
T-lymphocytes
Infection
Animals
Mice
description Barral Netto, Manoel. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 1992
dc.date.issued.fl_str_mv 1992
dc.date.accessioned.fl_str_mv 2018-05-10T14:25:32Z
dc.date.available.fl_str_mv 2018-05-10T14:25:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv POMPEU, M. et al. T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice. Parasitology Research, v. 78, p. 16-22, 1992.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/26380
dc.identifier.issn.pt_BR.fl_str_mv 0932-0113
identifier_str_mv POMPEU, M. et al. T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice. Parasitology Research, v. 78, p. 16-22, 1992.
0932-0113
url https://www.arca.fiocruz.br/handle/icict/26380
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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collection Repositório Institucional da FIOCRUZ (ARCA)
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