Seroprevalence and serum profile of cytomegalovirus infection among patients with hematologic disorders in Bahia State, Brazil

Detalhes bibliográficos
Autor(a) principal: Nascimento, Roberto José Meyer
Data de Publicação: 2011
Outros Autores: Lima, Fernanda Washington de Mendonça, Matos, Sócrates Bezerra de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/14893
Resumo: Texto completo: acesso restrito. p. 298–304
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spelling Nascimento, Roberto José MeyerLima, Fernanda Washington de MendonçaMatos, Sócrates Bezerra deNascimento, Roberto José MeyerLima, Fernanda Washington de MendonçaMatos, Sócrates Bezerra de2014-05-01T13:07:19Z20110146-6615http://repositorio.ufba.br/ri/handle/ri/14893v. 83, n. 2Texto completo: acesso restrito. p. 298–304Human cytomegalovirus (CMV) is a ubiquitous herpesvirus with from 30% to 100% of the general population exhibiting prior exposure by serology. This cross-sectional study evaluated the serological profile of anti-CMV antibodies and two acute-phase reaction proteins in Haematologic Disorder Patients (HDPs) from Bahia State, Brazil. Immuno-chemiluminescence assays were performed to detect anti-CMV IgM and IgG antibodies. Serological levels of High Sensitivity C-Reactive Protein (CRPH) and Alpha-1-Acid Glycoprotein (AAG) were measured using immunonephelometry. A total of 470 HDPs were enrolled, 238 (50.6%) males and 232 (49.4%) females. The overall seroprevalence of CMV was 89.4%, directly proportional to age and to the amount of blood units transfused. There was no difference between seroprevalence rates according to gender (P = 0.12). Four HDPs (0.9%) were seropositives for anti-CMV IgM, only one could be characterized as recent acute infection. The most CMV seropositive HDPs had anti-CMV IgG in low titers. There was a tendency for females to have higher anti-CMV IgG titers than men (P < 0.05). CRPH levels were different among HDPs CMV negative and positive groups (P < 0.001). There was no difference in the AAG levels between groups (P = 0.15). The high CMV seroprevalence found underscores the importance of using strategies to provide “CMV safe” blood to HDPs who are at high risk of developing severe CMV infection. CRPH can be used as a biomarker associated with CMV seropositivity; however, more efforts are needed to better characterize the clinical profile of active CMV infection in this group of patients.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-04-08T14:09:09Z No. of bitstreams: 1 Roberto Meyer.pdf: 138513 bytes, checksum: 82a31b77b3bcc1bcbbb6fc7035985356 (MD5)Approved for entry into archive by Patricia Barroso (pbarroso@ufba.br) on 2014-05-01T13:07:19Z (GMT) No. of bitstreams: 1 Roberto Meyer.pdf: 138513 bytes, checksum: 82a31b77b3bcc1bcbbb6fc7035985356 (MD5)Made available in DSpace on 2014-05-01T13:07:19Z (GMT). No. of bitstreams: 1 Roberto Meyer.pdf: 138513 bytes, checksum: 82a31b77b3bcc1bcbbb6fc7035985356 (MD5) Previous issue date: 2011http://dx.doi.org/ 10.1002/jmv.21965reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBACMVInfection profileAcute-phase proteinsCRPHAAGSeroprevalence and serum profile of cytomegalovirus infection among patients with hematologic disorders in Bahia State, BrazilJournal of Medical Virologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALRoberto Meyer.pdfRoberto Meyer.pdfapplication/pdf138513https://repositorio.ufba.br/bitstream/ri/14893/1/Roberto%20Meyer.pdf82a31b77b3bcc1bcbbb6fc7035985356MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/14893/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52TEXTRoberto Meyer.pdf.txtRoberto Meyer.pdf.txtExtracted texttext/plain30519https://repositorio.ufba.br/bitstream/ri/14893/3/Roberto%20Meyer.pdf.txt2cd816a701fbaa7509a2a2ce16a09ae7MD53ri/148932022-07-05 14:03:17.451oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:17Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Seroprevalence and serum profile of cytomegalovirus infection among patients with hematologic disorders in Bahia State, Brazil
dc.title.alternative.pt_BR.fl_str_mv Journal of Medical Virology
title Seroprevalence and serum profile of cytomegalovirus infection among patients with hematologic disorders in Bahia State, Brazil
spellingShingle Seroprevalence and serum profile of cytomegalovirus infection among patients with hematologic disorders in Bahia State, Brazil
Nascimento, Roberto José Meyer
CMV
Infection profile
Acute-phase proteins
CRPH
AAG
title_short Seroprevalence and serum profile of cytomegalovirus infection among patients with hematologic disorders in Bahia State, Brazil
title_full Seroprevalence and serum profile of cytomegalovirus infection among patients with hematologic disorders in Bahia State, Brazil
title_fullStr Seroprevalence and serum profile of cytomegalovirus infection among patients with hematologic disorders in Bahia State, Brazil
title_full_unstemmed Seroprevalence and serum profile of cytomegalovirus infection among patients with hematologic disorders in Bahia State, Brazil
title_sort Seroprevalence and serum profile of cytomegalovirus infection among patients with hematologic disorders in Bahia State, Brazil
author Nascimento, Roberto José Meyer
author_facet Nascimento, Roberto José Meyer
Lima, Fernanda Washington de Mendonça
Matos, Sócrates Bezerra de
author_role author
author2 Lima, Fernanda Washington de Mendonça
Matos, Sócrates Bezerra de
author2_role author
author
dc.contributor.author.fl_str_mv Nascimento, Roberto José Meyer
Lima, Fernanda Washington de Mendonça
Matos, Sócrates Bezerra de
Nascimento, Roberto José Meyer
Lima, Fernanda Washington de Mendonça
Matos, Sócrates Bezerra de
dc.subject.por.fl_str_mv CMV
Infection profile
Acute-phase proteins
CRPH
AAG
topic CMV
Infection profile
Acute-phase proteins
CRPH
AAG
description Texto completo: acesso restrito. p. 298–304
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2014-05-01T13:07:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/14893
dc.identifier.issn.none.fl_str_mv 0146-6615
dc.identifier.number.pt_BR.fl_str_mv v. 83, n. 2
identifier_str_mv 0146-6615
v. 83, n. 2
url http://repositorio.ufba.br/ri/handle/ri/14893
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/ 10.1002/jmv.21965
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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collection Repositório Institucional da UFBA
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