Effects of the extract of Anemopaegma mirandum (Catuaba) on Rotenone-induced apoptosis in human neuroblastomas SH-SY5Y cells
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/6348 |
Resumo: | Acesso restrito: Texto completo. p. 188-196 |
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Andrade, Deyse Valverde Gomes deOliveria, Diêgo Madureira deBarreto, George Emílio SampaioBertolino, Laura-AonSaraceno, EzequielCapani, FranciscoGiraldez, Lisandro DiegoAndrade, Deyse Valverde Gomes deOliveria, Diêgo Madureira deBarreto, George Emílio SampaioBertolino, Laura-AonSaraceno, EzequielCapani, FranciscoGiraldez, Lisandro Diego2012-07-05T19:08:33Z20080006-8993http://www.repositorio.ufba.br/ri/handle/ri/6348v. 1198Acesso restrito: Texto completo. p. 188-196Parkinson's disease (PD) is one of the most important neurodegenerativeworldwide disorders. It is characterized by a selective and progressive degeneration of dopaminergic neurons, causing a series of symptoms which might ultimately induce programmed cell death. The potential cytoprotective effects of one of the commercial extracts of Anemopaegma mirandum (Catuaba), a Brazilian tree, on Rotenone-induced apoptosis in human neuroblastomas SH-SY5Y cells was demonstrated. The cell viability, analysis of cellular morphology, nuclei morphology and ultra structural research were done by MTT-tetrazole (3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide) assay, phase contrast microscopy, stained with Hoechst 33258 and electron microscopy transmission, respectively. Three different concentrations of Catuaba extract were used (0.312, 0.625 and 1.250 mg/mL). These extracts promoted an increase of 22.3± 3.6%, 22.0±2.1% and 15.8±0.7% on the cell viability. Notable changes in the cellularmorphology, condensation of the cell body, nuclear fragmentation and condensation into discrete dense chromatin clumps were observed when the cells were treated with 300 nM Rotenone for 48 h. These effectswere partially alteredwhen the extract of A. mirandum was added to the Rotenone treatment. Ultra structural analysis by electron microscopy demonstrated that citoplasmatic membranes and mitochondria membrane were also clearly preserved in the group treatedwith the extract. Therefore, in this study, our findings indicated that extracts of A. mirandum have cytoprotective effects on Rotenone-induced apoptosis in humanneuroblastomas SH-SY5Y cells.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-07-05T19:08:33Z No. of bitstreams: 1 CONFIG~1....0-S0006899308000346-main.pdf: 461689 bytes, checksum: a281cf3ad3f9bcfbbe293b5952e4dd24 (MD5)Made available in DSpace on 2012-07-05T19:08:33Z (GMT). No. of bitstreams: 1 CONFIG~1....0-S0006899308000346-main.pdf: 461689 bytes, checksum: a281cf3ad3f9bcfbbe293b5952e4dd24 (MD5) Previous issue date: 2008http://dx.doi.org/10.1016/j.brainres.2008.01.006reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAParkinson diseaseSH-SY5Y cellsCatuabaCytoprotectiveRotenoneEffects of the extract of Anemopaegma mirandum (Catuaba) on Rotenone-induced apoptosis in human neuroblastomas SH-SY5Y cellsBrain Researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALCONFIG~1....0-S0006899308000346-main.pdfCONFIG~1....0-S0006899308000346-main.pdfapplication/pdf461689https://repositorio.ufba.br/bitstream/ri/6348/1/CONFIG~1....0-S0006899308000346-main.pdfa281cf3ad3f9bcfbbe293b5952e4dd24MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/6348/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTCONFIG~1....0-S0006899308000346-main.pdf.txtCONFIG~1....0-S0006899308000346-main.pdf.txtExtracted texttext/plain39872https://repositorio.ufba.br/bitstream/ri/6348/3/CONFIG~1....0-S0006899308000346-main.pdf.txtacf262ee334f3c2e3fce26c949d1af18MD53ri/63482022-07-05 14:03:21.866oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:21Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Effects of the extract of Anemopaegma mirandum (Catuaba) on Rotenone-induced apoptosis in human neuroblastomas SH-SY5Y cells |
dc.title.alternative.pt_BR.fl_str_mv |
Brain Research |
title |
Effects of the extract of Anemopaegma mirandum (Catuaba) on Rotenone-induced apoptosis in human neuroblastomas SH-SY5Y cells |
spellingShingle |
Effects of the extract of Anemopaegma mirandum (Catuaba) on Rotenone-induced apoptosis in human neuroblastomas SH-SY5Y cells Andrade, Deyse Valverde Gomes de Parkinson disease SH-SY5Y cells Catuaba Cytoprotective Rotenone |
title_short |
Effects of the extract of Anemopaegma mirandum (Catuaba) on Rotenone-induced apoptosis in human neuroblastomas SH-SY5Y cells |
title_full |
Effects of the extract of Anemopaegma mirandum (Catuaba) on Rotenone-induced apoptosis in human neuroblastomas SH-SY5Y cells |
title_fullStr |
Effects of the extract of Anemopaegma mirandum (Catuaba) on Rotenone-induced apoptosis in human neuroblastomas SH-SY5Y cells |
title_full_unstemmed |
Effects of the extract of Anemopaegma mirandum (Catuaba) on Rotenone-induced apoptosis in human neuroblastomas SH-SY5Y cells |
title_sort |
Effects of the extract of Anemopaegma mirandum (Catuaba) on Rotenone-induced apoptosis in human neuroblastomas SH-SY5Y cells |
author |
Andrade, Deyse Valverde Gomes de |
author_facet |
Andrade, Deyse Valverde Gomes de Oliveria, Diêgo Madureira de Barreto, George Emílio Sampaio Bertolino, Laura-Aon Saraceno, Ezequiel Capani, Francisco Giraldez, Lisandro Diego |
author_role |
author |
author2 |
Oliveria, Diêgo Madureira de Barreto, George Emílio Sampaio Bertolino, Laura-Aon Saraceno, Ezequiel Capani, Francisco Giraldez, Lisandro Diego |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Andrade, Deyse Valverde Gomes de Oliveria, Diêgo Madureira de Barreto, George Emílio Sampaio Bertolino, Laura-Aon Saraceno, Ezequiel Capani, Francisco Giraldez, Lisandro Diego Andrade, Deyse Valverde Gomes de Oliveria, Diêgo Madureira de Barreto, George Emílio Sampaio Bertolino, Laura-Aon Saraceno, Ezequiel Capani, Francisco Giraldez, Lisandro Diego |
dc.subject.por.fl_str_mv |
Parkinson disease SH-SY5Y cells Catuaba Cytoprotective Rotenone |
topic |
Parkinson disease SH-SY5Y cells Catuaba Cytoprotective Rotenone |
description |
Acesso restrito: Texto completo. p. 188-196 |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008 |
dc.date.accessioned.fl_str_mv |
2012-07-05T19:08:33Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
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publishedVersion |
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http://www.repositorio.ufba.br/ri/handle/ri/6348 |
dc.identifier.issn.none.fl_str_mv |
0006-8993 |
dc.identifier.number.pt_BR.fl_str_mv |
v. 1198 |
identifier_str_mv |
0006-8993 v. 1198 |
url |
http://www.repositorio.ufba.br/ri/handle/ri/6348 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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http://dx.doi.org/10.1016/j.brainres.2008.01.006 |
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