In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 1996 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/8539 |
Resumo: | Texto completo: acesso restrito. p.237–250 |
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1932 |
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Barral-Netto, ManoelSohsten, R. L. VonTeixeira, M.Santos, Washington Luis Conrado dosPompeu, M. L.Moreira, R. A.Oliveira, J. T. A.Cavada, B. S.Falcoff, E.Barral, Aldina Maria PradoBarral-Netto, ManoelSohsten, R. L. VonTeixeira, M.Santos, Washington Luis Conrado dosPompeu, M. L.Moreira, R. A.Oliveira, J. T. A.Cavada, B. S.Falcoff, E.Barral, Aldina Maria Prado2013-02-19T16:26:27Z19960001-706Xhttp://www.repositorio.ufba.br/ri/handle/ri/8539v. 60, n. 4Texto completo: acesso restrito. p.237–250In vivo administration of Canavalia brasiliensis lectin (at the time of infection, or maintained throughout the infection) reduced the lesions of highly susceptible BALB/c mice infected by Leishmania amazonensis. At the doses used C. brasiliensis lectin (ConBr) does not interfere with penetration or fate of Leishmania in the macrophages in vitro. Since Interferon-γ (IFN-γ) is the major macrophage activating factor, and considered a critical element in the successful immune response against leishmaniasis, we explored its participation in this phenomenon. ConBr either in vivo or in vitro induced IFN-γ production in normal or in leishmania-infected BALB/c mice. However we were unable to change the course of disease by in vivo IFN-γ administration (although IFN-γ preparations were effective in inducing a leishmanicidal effect in vitro on L. amazonensis-infected peritoneal macrophages). Additionally, IFN-γ neutralization with anti-IFN-γ monoclonal antibody did not alter the protection conferred by ConBr administration. These data show that lectin administration in vivo is protective in the otherwise unchecked L. amazonensis infection of BALB/c mice, and suggest that such effect is not mediated by IFN-γ.Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2013-02-15T16:22:53Z No. of bitstreams: 1 Barral.pdf: 1666412 bytes, checksum: 9ad16b3ea81362338e178cbdbb4c83a7 (MD5)Approved for entry into archive by Fatima Cleômenis Botelho Maria (botelho@ufba.br) on 2013-02-19T16:26:27Z (GMT) No. of bitstreams: 1 Barral.pdf: 1666412 bytes, checksum: 9ad16b3ea81362338e178cbdbb4c83a7 (MD5)Made available in DSpace on 2013-02-19T16:26:27Z (GMT). No. of bitstreams: 1 Barral.pdf: 1666412 bytes, checksum: 9ad16b3ea81362338e178cbdbb4c83a7 (MD5) Previous issue date: 1996http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/0001-706X(95)00120-4reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBALeishmania amazonensiLeishmaniasisLeishmaniaTegumentary leishmaniasisExperimental leishmaniasisCanavalia brasiliensisInterferon-γIn vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensisActa Tropicainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALBarral.pdfBarral.pdfapplication/pdf1666412https://repositorio.ufba.br/bitstream/ri/8539/1/Barral.pdf9ad16b3ea81362338e178cbdbb4c83a7MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/8539/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52ri/85392022-08-08 13:17:35.864oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:17:35Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis |
| dc.title.alternative.pt_BR.fl_str_mv |
Acta Tropica |
| title |
In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis |
| spellingShingle |
In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis Barral-Netto, Manoel Leishmania amazonensi Leishmaniasis Leishmania Tegumentary leishmaniasis Experimental leishmaniasis Canavalia brasiliensis Interferon-γ |
| title_short |
In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis |
| title_full |
In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis |
| title_fullStr |
In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis |
| title_full_unstemmed |
In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis |
| title_sort |
In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis |
| author |
Barral-Netto, Manoel |
| author_facet |
Barral-Netto, Manoel Sohsten, R. L. Von Teixeira, M. Santos, Washington Luis Conrado dos Pompeu, M. L. Moreira, R. A. Oliveira, J. T. A. Cavada, B. S. Falcoff, E. Barral, Aldina Maria Prado |
| author_role |
author |
| author2 |
Sohsten, R. L. Von Teixeira, M. Santos, Washington Luis Conrado dos Pompeu, M. L. Moreira, R. A. Oliveira, J. T. A. Cavada, B. S. Falcoff, E. Barral, Aldina Maria Prado |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Barral-Netto, Manoel Sohsten, R. L. Von Teixeira, M. Santos, Washington Luis Conrado dos Pompeu, M. L. Moreira, R. A. Oliveira, J. T. A. Cavada, B. S. Falcoff, E. Barral, Aldina Maria Prado Barral-Netto, Manoel Sohsten, R. L. Von Teixeira, M. Santos, Washington Luis Conrado dos Pompeu, M. L. Moreira, R. A. Oliveira, J. T. A. Cavada, B. S. Falcoff, E. Barral, Aldina Maria Prado |
| dc.subject.por.fl_str_mv |
Leishmania amazonensi Leishmaniasis Leishmania Tegumentary leishmaniasis Experimental leishmaniasis Canavalia brasiliensis Interferon-γ |
| topic |
Leishmania amazonensi Leishmaniasis Leishmania Tegumentary leishmaniasis Experimental leishmaniasis Canavalia brasiliensis Interferon-γ |
| description |
Texto completo: acesso restrito. p.237–250 |
| publishDate |
1996 |
| dc.date.issued.fl_str_mv |
1996 |
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2013-02-19T16:26:27Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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http://www.repositorio.ufba.br/ri/handle/ri/8539 |
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0001-706X |
| dc.identifier.number.pt_BR.fl_str_mv |
v. 60, n. 4 |
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0001-706X v. 60, n. 4 |
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http://www.repositorio.ufba.br/ri/handle/ri/8539 |
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http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/0001-706X(95)00120-4 |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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