Human anti-saliva immune response following experimental exposure to the visceral leishmaniasis vector, Lutzomyia longipalpis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2007 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/14316 |
Resumo: | Texto completo: acesso restrito. p. 3111-3121 |
| id |
UFBA-2_42735c1a064b978bb60391c85505e21f |
|---|---|
| oai_identifier_str |
oai:repositorio.ufba.br:ri/14316 |
| network_acronym_str |
UFBA-2 |
| network_name_str |
Repositório Institucional da UFBA |
| repository_id_str |
1932 |
| spelling |
Vinhas, Vera Silvia de FreitasAndrade, Bruno BezerrilPaes, FábioBomura, AndréaClarencio, JorgeMiranda, José C.Báfica, Andre Luiz BarbosaBarral, Aldina Maria PradoBarral-Netto, ManoelVinhas, Vera Silvia de FreitasAndrade, Bruno BezerrilPaes, FábioBomura, AndréaClarencio, JorgeMiranda, José C.Báfica, Andre Luiz BarbosaBarral, Aldina Maria PradoBarral-Netto, Manoel2014-01-10T16:38:50Z20070014-2980http://repositorio.ufba.br/ri/handle/ri/14316v. 37, n. 11Texto completo: acesso restrito. p. 3111-3121Experiments in animals verified that phlebotomine saliva enhances Leishmania infection, and vaccination with saliva prevents disease. We have shown that individuals from an endemic area of visceral leishmaniasis displayed robust antibody responses to saliva from the vector Lutzomyialongipalpis, which correlated with anti-parasite cell-mediated immunity. Here, we explored human anti-saliva responses following exposure to sand flies, using an in vivo bite model in which normal volunteers were exposed four times to 30 laboratory-reared Lu. longipalpis. Following the third exposure, normal volunteers developed diverse dermatological reactions at the site of insect bite. Serum from normal volunteers displayed high levels of anti-salivary gland sonicate IgG1, IgG4 and IgE as well as several salivary gland proteins. Furthermore, following in vitro stimulation with salivary gland sonicate, there was an increased frequency of CD4+CD25+ and CD8+CD25+ T cells as well as IFN-γ and IL-10 synthesis. Strikingly, 1 year after the first exposure, PBMC from the volunteers displayed recall IFN-γ responses that correlated with a significant reduction in infection rates using a macrophage-lymphocyte autologous culture. Together, these data suggest that human immunization against sand fly saliva is feasible and recall responses are obtained even 1 year after exposure, opening perspectives for vaccination in man.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-01-10T14:57:03Z No. of bitstreams: 1 10.1002-eji.200737431.pdf: 347167 bytes, checksum: 54a24ccf2c3aab33b0ff6aebd5613dc7 (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-01-10T16:38:50Z (GMT) No. of bitstreams: 1 10.1002-eji.200737431.pdf: 347167 bytes, checksum: 54a24ccf2c3aab33b0ff6aebd5613dc7 (MD5)Made available in DSpace on 2014-01-10T16:38:50Z (GMT). No. of bitstreams: 1 10.1002-eji.200737431.pdf: 347167 bytes, checksum: 54a24ccf2c3aab33b0ff6aebd5613dc7 (MD5) Previous issue date: 2007http://dx.doi.org/10.1002/eji.200737431reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBACytokinesHumanSalivaSand flyHuman anti-saliva immune response following experimental exposure to the visceral leishmaniasis vector, Lutzomyia longipalpisEuropean Journal of Immunologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL10.1002-eji.200737431.pdf10.1002-eji.200737431.pdfapplication/pdf347167https://repositorio.ufba.br/bitstream/ri/14316/1/10.1002-eji.200737431.pdf54a24ccf2c3aab33b0ff6aebd5613dc7MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/14316/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXT10.1002-eji.200737431.pdf.txt10.1002-eji.200737431.pdf.txtExtracted texttext/plain44807https://repositorio.ufba.br/bitstream/ri/14316/3/10.1002-eji.200737431.pdf.txt49e6f48e893cede3d20c9220f60f4371MD53ri/143162022-07-05 14:03:46.56oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:46Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Human anti-saliva immune response following experimental exposure to the visceral leishmaniasis vector, Lutzomyia longipalpis |
| dc.title.alternative.pt_BR.fl_str_mv |
European Journal of Immunology |
| title |
Human anti-saliva immune response following experimental exposure to the visceral leishmaniasis vector, Lutzomyia longipalpis |
| spellingShingle |
Human anti-saliva immune response following experimental exposure to the visceral leishmaniasis vector, Lutzomyia longipalpis Vinhas, Vera Silvia de Freitas Cytokines Human Saliva Sand fly |
| title_short |
Human anti-saliva immune response following experimental exposure to the visceral leishmaniasis vector, Lutzomyia longipalpis |
| title_full |
Human anti-saliva immune response following experimental exposure to the visceral leishmaniasis vector, Lutzomyia longipalpis |
| title_fullStr |
Human anti-saliva immune response following experimental exposure to the visceral leishmaniasis vector, Lutzomyia longipalpis |
| title_full_unstemmed |
Human anti-saliva immune response following experimental exposure to the visceral leishmaniasis vector, Lutzomyia longipalpis |
| title_sort |
Human anti-saliva immune response following experimental exposure to the visceral leishmaniasis vector, Lutzomyia longipalpis |
| author |
Vinhas, Vera Silvia de Freitas |
| author_facet |
Vinhas, Vera Silvia de Freitas Andrade, Bruno Bezerril Paes, Fábio Bomura, Andréa Clarencio, Jorge Miranda, José C. Báfica, Andre Luiz Barbosa Barral, Aldina Maria Prado Barral-Netto, Manoel |
| author_role |
author |
| author2 |
Andrade, Bruno Bezerril Paes, Fábio Bomura, Andréa Clarencio, Jorge Miranda, José C. Báfica, Andre Luiz Barbosa Barral, Aldina Maria Prado Barral-Netto, Manoel |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Vinhas, Vera Silvia de Freitas Andrade, Bruno Bezerril Paes, Fábio Bomura, Andréa Clarencio, Jorge Miranda, José C. Báfica, Andre Luiz Barbosa Barral, Aldina Maria Prado Barral-Netto, Manoel Vinhas, Vera Silvia de Freitas Andrade, Bruno Bezerril Paes, Fábio Bomura, Andréa Clarencio, Jorge Miranda, José C. Báfica, Andre Luiz Barbosa Barral, Aldina Maria Prado Barral-Netto, Manoel |
| dc.subject.por.fl_str_mv |
Cytokines Human Saliva Sand fly |
| topic |
Cytokines Human Saliva Sand fly |
| description |
Texto completo: acesso restrito. p. 3111-3121 |
| publishDate |
2007 |
| dc.date.issued.fl_str_mv |
2007 |
| dc.date.accessioned.fl_str_mv |
2014-01-10T16:38:50Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://repositorio.ufba.br/ri/handle/ri/14316 |
| dc.identifier.issn.none.fl_str_mv |
0014-2980 |
| dc.identifier.number.pt_BR.fl_str_mv |
v. 37, n. 11 |
| identifier_str_mv |
0014-2980 v. 37, n. 11 |
| url |
http://repositorio.ufba.br/ri/handle/ri/14316 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.source.pt_BR.fl_str_mv |
http://dx.doi.org/10.1002/eji.200737431 |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
| instname_str |
Universidade Federal da Bahia (UFBA) |
| instacron_str |
UFBA |
| institution |
UFBA |
| reponame_str |
Repositório Institucional da UFBA |
| collection |
Repositório Institucional da UFBA |
| bitstream.url.fl_str_mv |
https://repositorio.ufba.br/bitstream/ri/14316/1/10.1002-eji.200737431.pdf https://repositorio.ufba.br/bitstream/ri/14316/2/license.txt https://repositorio.ufba.br/bitstream/ri/14316/3/10.1002-eji.200737431.pdf.txt |
| bitstream.checksum.fl_str_mv |
54a24ccf2c3aab33b0ff6aebd5613dc7 ff6eaa8b858ea317fded99f125f5fcd0 49e6f48e893cede3d20c9220f60f4371 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA) |
| repository.mail.fl_str_mv |
|
| _version_ |
1808459468623577088 |