Variants in the toll-like receptor signaling pathway and clinical outcomes of malaria

Detalhes bibliográficos
Autor(a) principal: Leoratti, Fabiana M. S.
Data de Publicação: 2008
Outros Autores: Farias, Lilian, Alves, Fabiana P., Suarez Mútis, Martha C., Coura, José R., Kalil, Jorge, Camargo, Erney Plessmann, Moraes, Sandra L, Ramasawmy, Rajendranath
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/13889
Resumo: Texto completo: acesso restrito. p. 772-780
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spelling Leoratti, Fabiana M. S.Farias, LilianAlves, Fabiana P.Suarez Mútis, Martha C.Coura, José R.Kalil, JorgeCamargo, Erney PlessmannMoraes, Sandra LRamasawmy, RajendranathLeoratti, Fabiana M. S.Farias, LilianAlves, Fabiana P.Suarez Mútis, Martha C.Coura, José R.Kalil, JorgeCamargo, Erney PlessmannMoraes, Sandra LRamasawmy, Rajendranath2013-11-26T12:56:08Z20080022-1899http://repositorio.ufba.br/ri/handle/ri/13889v. 198, n. 5Texto completo: acesso restrito. p. 772-780Background. Malaria is one of the most significant infectious diseases in the world and is responsible for a large proportion of infant deaths. Toll-like receptors (TLRs), key components of innate immunity, are central to countering infection. Variants in the TLR-signaling pathway are associated with susceptibility to infectious diseases. Methods. We genotyped single nucleotide polymorphisms (SNPs) of the genes associated with the TLR-signaling pathway in patients with mild malaria and individuals with asymptomatic Plasmodium infections by means of polymerase chain reaction. Results. Genotype distributions for the TLR-1 I602S differed significantly between patients with mild malaria and persons with asymptomatic infection. The TLR-1 602S allele was associated with an odds ratio (OR) of 2.2 (P = .003; Pcorrected = .015) for malaria among patients with mild malaria due to any Plasmodium species and 2.1 (P = .015; Pcorrected = .75) among patients with mild malaria due to Plasmodium falciparum only. The TLR-6 S249P SNP showed an excess of homozygotes for the TLR-6 249P allele in asymptomatic persons, compared with patients with mild malaria due to any Plasmodium species (OR 2.1; 95% confidence interval [CI], 1.1–4.2; P = .01; Pcorrected = .05), suggesting that the TLR-6 249S allele may be a risk factor for malaria (OR, 2.0; 95% CI, 1.1–3.7; P = 0.01; Pcorrected = .05). The TLR-9 -1486C allele showed a strong association with high parasitemia (P < .001). Conclusions. Our findings indicate that the TLR-1 and TLR-6 variants are significantly associated with mild malaria, whereas the TLR-9-1486C/T variants are associated with high parasitemia. These discoveries may bring additional understanding to the pathogenesis of malaria.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-11-26T11:37:19Z No. of bitstreams: 1 J Infect Dis.-2008-Leoratti-772-80.pdf: 112552 bytes, checksum: 3c317af743e0bce490179520841c834c (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-26T12:56:08Z (GMT) No. of bitstreams: 1 J Infect Dis.-2008-Leoratti-772-80.pdf: 112552 bytes, checksum: 3c317af743e0bce490179520841c834c (MD5)Made available in DSpace on 2013-11-26T12:56:08Z (GMT). No. of bitstreams: 1 J Infect Dis.-2008-Leoratti-772-80.pdf: 112552 bytes, checksum: 3c317af743e0bce490179520841c834c (MD5) Previous issue date: 2008http://dx.doi.org/10.1086/590440reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAVariants in the toll-like receptor signaling pathway and clinical outcomes of malariaJournal of Infectious Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALJ Infect Dis.-2008-Leoratti-772-80.pdfJ Infect Dis.-2008-Leoratti-772-80.pdfapplication/pdf112552https://repositorio.ufba.br/bitstream/ri/13889/1/J%20Infect%20Dis.-2008-Leoratti-772-80.pdf3c317af743e0bce490179520841c834cMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/13889/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTJ Infect Dis.-2008-Leoratti-772-80.pdf.txtJ Infect Dis.-2008-Leoratti-772-80.pdf.txtExtracted texttext/plain41915https://repositorio.ufba.br/bitstream/ri/13889/3/J%20Infect%20Dis.-2008-Leoratti-772-80.pdf.txta551c2bb5291f7e200b3a466d436c1e8MD53ri/138892022-07-05 14:03:01.549oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:01Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Variants in the toll-like receptor signaling pathway and clinical outcomes of malaria
dc.title.alternative.pt_BR.fl_str_mv Journal of Infectious Diseases
title Variants in the toll-like receptor signaling pathway and clinical outcomes of malaria
spellingShingle Variants in the toll-like receptor signaling pathway and clinical outcomes of malaria
Leoratti, Fabiana M. S.
title_short Variants in the toll-like receptor signaling pathway and clinical outcomes of malaria
title_full Variants in the toll-like receptor signaling pathway and clinical outcomes of malaria
title_fullStr Variants in the toll-like receptor signaling pathway and clinical outcomes of malaria
title_full_unstemmed Variants in the toll-like receptor signaling pathway and clinical outcomes of malaria
title_sort Variants in the toll-like receptor signaling pathway and clinical outcomes of malaria
author Leoratti, Fabiana M. S.
author_facet Leoratti, Fabiana M. S.
Farias, Lilian
Alves, Fabiana P.
Suarez Mútis, Martha C.
Coura, José R.
Kalil, Jorge
Camargo, Erney Plessmann
Moraes, Sandra L
Ramasawmy, Rajendranath
author_role author
author2 Farias, Lilian
Alves, Fabiana P.
Suarez Mútis, Martha C.
Coura, José R.
Kalil, Jorge
Camargo, Erney Plessmann
Moraes, Sandra L
Ramasawmy, Rajendranath
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Leoratti, Fabiana M. S.
Farias, Lilian
Alves, Fabiana P.
Suarez Mútis, Martha C.
Coura, José R.
Kalil, Jorge
Camargo, Erney Plessmann
Moraes, Sandra L
Ramasawmy, Rajendranath
Leoratti, Fabiana M. S.
Farias, Lilian
Alves, Fabiana P.
Suarez Mútis, Martha C.
Coura, José R.
Kalil, Jorge
Camargo, Erney Plessmann
Moraes, Sandra L
Ramasawmy, Rajendranath
description Texto completo: acesso restrito. p. 772-780
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2013-11-26T12:56:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/13889
dc.identifier.issn.none.fl_str_mv 0022-1899
dc.identifier.number.pt_BR.fl_str_mv v. 198, n. 5
identifier_str_mv 0022-1899
v. 198, n. 5
url http://repositorio.ufba.br/ri/handle/ri/13889
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1086/590440
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