Genetic variability of human immunodeficiency virus-1 in Bahia state, Northeast, Brazil: High diversity of HIV genotypes
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/13707 |
Resumo: | Texto completo: acesso restrito. p. 391–399 |
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Monteiro, Joana PaixãoAlcântara, Luiz Carlos JúniorOliveira, Tulio deOliveira, Antonio MarcosMelo, Marco Antônio GomesBrites, CarlosCastro, Bernardo GalvãoMonteiro, Joana PaixãoAlcântara, Luiz Carlos JúniorOliveira, Tulio deOliveira, Antonio MarcosMelo, Marco Antônio GomesBrites, CarlosCastro, Bernardo Galvão2013-11-18T20:52:34Z20090146-6615http://repositorio.ufba.br/ri/handle/ri/13707v. 81, n. 3Texto completo: acesso restrito. p. 391–399The HIV-1 genetic variability in Bahia state, Brazil, was investigated. DNA samples from 229 and 213 HIV-1-infected individuals were analyzed using the heteroduplex mobility assay (HMA) in gag and env fragments, respectively. One hundred seventy-five samples were characterized in both genes. Thirty-two subtype F and BF recombinant viruses were sequenced and analyzed by phylogenetic methods. The combination of HMA and sequencing results showed that seven different HIV-1 genotypes comprised this sample: 147 (84%) B/B, 4 (2.3%) F/F, 3 (1.7%) B/F, 1 (0.6%) F/B, 1 (0.6%) F/D, 1 (0.6%) BF/F, and 18 (10.3%) BF/B. A significant divergence was observed between these two techniques results (84.4%). This is explained by the low accuracy of the HMA for detecting recombinant viruses. These recombinants were unrelated to CRF12, while two sequences were related to CRF28 and CRF29. Nineteen BF mosaics shared the same gag breakpoint. In conclusion, the use of HMA may be inappropriate in regions where different subtypes are co-circulating. Subtype B is the most common genotype, however, an increased prevalence (13.1%) of different BF variants and a potentially new CRF suggest that recombination is occurring frequently in Bahia. These viruses were associated with women infected heterosexually. Finally, this study identified the presence of an F/D recombinant HIV-1 in Brazil.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-10-29T16:08:18Z No. of bitstreams: 1 21414_ftp.pdf: 269246 bytes, checksum: 37ce18cd263f9f02f477c37f23d310ec (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-18T20:52:34Z (GMT) No. of bitstreams: 1 21414_ftp.pdf: 269246 bytes, checksum: 37ce18cd263f9f02f477c37f23d310ec (MD5)Made available in DSpace on 2013-11-18T20:52:34Z (GMT). No. of bitstreams: 1 21414_ftp.pdf: 269246 bytes, checksum: 37ce18cd263f9f02f477c37f23d310ec (MD5) Previous issue date: 2009http://dx.doi.org/10.1002/jmv.21414reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAHIV-1EpidemiologyPhylogenyBrazilBahiaGenetic variability of human immunodeficiency virus-1 in Bahia state, Northeast, Brazil: High diversity of HIV genotypesJournal of Medical Virologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL21414_ftp.pdf21414_ftp.pdfapplication/pdf269246https://repositorio.ufba.br/bitstream/ri/13707/1/21414_ftp.pdf37ce18cd263f9f02f477c37f23d310ecMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/13707/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXT21414_ftp.pdf.txt21414_ftp.pdf.txtExtracted texttext/plain39310https://repositorio.ufba.br/bitstream/ri/13707/3/21414_ftp.pdf.txtef28d994dde7b4abc78e78e0f09cd8b3MD53ri/137072022-07-05 14:04:17.874oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:04:17Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Genetic variability of human immunodeficiency virus-1 in Bahia state, Northeast, Brazil: High diversity of HIV genotypes |
dc.title.alternative.pt_BR.fl_str_mv |
Journal of Medical Virology |
title |
Genetic variability of human immunodeficiency virus-1 in Bahia state, Northeast, Brazil: High diversity of HIV genotypes |
spellingShingle |
Genetic variability of human immunodeficiency virus-1 in Bahia state, Northeast, Brazil: High diversity of HIV genotypes Monteiro, Joana Paixão HIV-1 Epidemiology Phylogeny Brazil Bahia |
title_short |
Genetic variability of human immunodeficiency virus-1 in Bahia state, Northeast, Brazil: High diversity of HIV genotypes |
title_full |
Genetic variability of human immunodeficiency virus-1 in Bahia state, Northeast, Brazil: High diversity of HIV genotypes |
title_fullStr |
Genetic variability of human immunodeficiency virus-1 in Bahia state, Northeast, Brazil: High diversity of HIV genotypes |
title_full_unstemmed |
Genetic variability of human immunodeficiency virus-1 in Bahia state, Northeast, Brazil: High diversity of HIV genotypes |
title_sort |
Genetic variability of human immunodeficiency virus-1 in Bahia state, Northeast, Brazil: High diversity of HIV genotypes |
author |
Monteiro, Joana Paixão |
author_facet |
Monteiro, Joana Paixão Alcântara, Luiz Carlos Júnior Oliveira, Tulio de Oliveira, Antonio Marcos Melo, Marco Antônio Gomes Brites, Carlos Castro, Bernardo Galvão |
author_role |
author |
author2 |
Alcântara, Luiz Carlos Júnior Oliveira, Tulio de Oliveira, Antonio Marcos Melo, Marco Antônio Gomes Brites, Carlos Castro, Bernardo Galvão |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Monteiro, Joana Paixão Alcântara, Luiz Carlos Júnior Oliveira, Tulio de Oliveira, Antonio Marcos Melo, Marco Antônio Gomes Brites, Carlos Castro, Bernardo Galvão Monteiro, Joana Paixão Alcântara, Luiz Carlos Júnior Oliveira, Tulio de Oliveira, Antonio Marcos Melo, Marco Antônio Gomes Brites, Carlos Castro, Bernardo Galvão |
dc.subject.por.fl_str_mv |
HIV-1 Epidemiology Phylogeny Brazil Bahia |
topic |
HIV-1 Epidemiology Phylogeny Brazil Bahia |
description |
Texto completo: acesso restrito. p. 391–399 |
publishDate |
2009 |
dc.date.issued.fl_str_mv |
2009 |
dc.date.accessioned.fl_str_mv |
2013-11-18T20:52:34Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufba.br/ri/handle/ri/13707 |
dc.identifier.issn.none.fl_str_mv |
0146-6615 |
dc.identifier.number.pt_BR.fl_str_mv |
v. 81, n. 3 |
identifier_str_mv |
0146-6615 v. 81, n. 3 |
url |
http://repositorio.ufba.br/ri/handle/ri/13707 |
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eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.source.pt_BR.fl_str_mv |
http://dx.doi.org/10.1002/jmv.21414 |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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Universidade Federal da Bahia (UFBA) |
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UFBA |
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