T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice

Detalhes bibliográficos
Autor(a) principal: Pompeu, M.
Data de Publicação: 1992
Outros Autores: Freitas, A. L., Reis, G. A. dos, Barral-Netto, Manoel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/7404
Resumo: p. 16-22
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spelling Pompeu, M.Freitas, A. L.Reis, G. A. dosBarral-Netto, ManoelPompeu, M.Freitas, A. L.Reis, G. A. dosBarral-Netto, Manoel2012-12-11T18:59:19Z2012-12-11T18:59:19Z1992http://www.repositorio.ufba.br/ri/handle/ri/7404v. 78, n.1p. 16-22Highly susceptible naive BALB/c mice or mice that had previously been immunized i.v. with solubilized homologous antigen (partially resistant) were infected with Leishmania amazonensis. Histologically, the main differences between the two groups were lymphocytic infiltration and macrophage activation. Assays of T-cell function at 3 and 10 weeks after infection revealed that purified T-cells did not proliferate following treatment with leishmania antigen. A mitogenic anti-CD3 monoclonal antibody (mAb) failed to activate T-cells after 3 weeks of infection as judged by proliferation and IL-2 secretion assays. After 10 weeks of infection, anti-CD3 mAb fully activated T-cells to proliferation and IL-2 secretion. On the other hand, T-cells released IL-3 in response to leishmania antigen, anti-CD3 mAb and anti- Thyl mAb at 3 and 10 weeks post-infection. Surprisingly, a mitogenic anti-Thy 1 mAb (G7) fully activated Tcells even at 3 weeks of infection as judged by proliferative and IL-2 secretion assays. No significant differences were found in the proliferative or interleukin secretory responses of T-cells from animals that had been infected in either the presence or the absence of prior immunization. Since the Thyl triggering pathway has different accessory cell and cytokine requirements than does the CD3 : TCR lymphocyte activation pathway, it is possible that immunization was more effective in changing the cellular interactions of the T-lymphocyte than in altering its intrinsic capabilities.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2012-12-11T18:59:19Z No. of bitstreams: 1 SSSSSS8596.pdf: 781353 bytes, checksum: 2466c51a033fd51c40cadc8ee1c0f23d (MD5)Made available in DSpace on 2012-12-11T18:59:19Z (GMT). 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dc.title.pt_BR.fl_str_mv T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice
dc.title.alternative.pt_BR.fl_str_mv Parasitology Research
title T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice
spellingShingle T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice
Pompeu, M.
title_short T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice
title_full T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice
title_fullStr T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice
title_full_unstemmed T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice
title_sort T-lymphocytes in experimental Leishmania amazonensis infection: comparison between immunized and naive BALB/c mice
author Pompeu, M.
author_facet Pompeu, M.
Freitas, A. L.
Reis, G. A. dos
Barral-Netto, Manoel
author_role author
author2 Freitas, A. L.
Reis, G. A. dos
Barral-Netto, Manoel
author2_role author
author
author
dc.contributor.author.fl_str_mv Pompeu, M.
Freitas, A. L.
Reis, G. A. dos
Barral-Netto, Manoel
Pompeu, M.
Freitas, A. L.
Reis, G. A. dos
Barral-Netto, Manoel
description p. 16-22
publishDate 1992
dc.date.issued.fl_str_mv 1992
dc.date.accessioned.fl_str_mv 2012-12-11T18:59:19Z
dc.date.available.fl_str_mv 2012-12-11T18:59:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7404
dc.identifier.number.pt_BR.fl_str_mv v. 78, n.1
url http://www.repositorio.ufba.br/ri/handle/ri/7404
identifier_str_mv v. 78, n.1
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Parasitology Research
publisher.none.fl_str_mv Parasitology Research
dc.source.pt_BR.fl_str_mv 10.1007/BF00936175
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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instname_str Universidade Federal da Bahia (UFBA)
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reponame_str Repositório Institucional da UFBA
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