Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosomamansoni Infection

Detalhes bibliográficos
Autor(a) principal: Carvalho Filho, Edgar Marcelino de
Data de Publicação: 2012
Outros Autores: Oliveira, Ricardo Riccio, Araujo, Maria Ilma Andrade Santos, Souza, Robson da Paixão de, Cardoso, Luciana Santos, Lopes, Giuseppe Tittoni Varela, Almeida, Maria Cecilia Freitas de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/16063
Resumo: p. 1-10
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spelling Carvalho Filho, Edgar Marcelino deOliveira, Ricardo RiccioAraujo, Maria Ilma Andrade SantosSouza, Robson da Paixão deCardoso, Luciana SantosLopes, Giuseppe Tittoni VarelaAlmeida, Maria Cecilia Freitas deCarvalho Filho, Edgar Marcelino deOliveira, Ricardo RiccioAraujo, Maria Ilma Andrade SantosSouza, Robson da Paixão deCardoso, Luciana SantosLopes, Giuseppe Tittoni VarelaAlmeida, Maria Cecilia Freitas de2014-09-11T17:55:38Z2014-09-11T17:55:38Z20122090-0023http://repositorio.ufba.br/ri/handle/ri/16063p. 1-10Periportal fibrosis in schistosomiasis has been associated to the host immune response to parasite antigens. We evaluated the immune response in S. mansoni infected individuals with different degrees of periportal fibrosis. Cytokine and chemokines were measured in serum and in supernatants of PBMC cultures stimulated with the soluble adult worm (SWAP) or egg (SEA) antigens, using a sandwich ELISA. The levels of IL-5 in response to SEA were higher in individuals with moderate to severe fibrosis (310.9 pg/mL) compared to individuals without fibrosis (36.8 pg/mL; P = 0.0418). There was also a higher production of TNF-α in cultures stimulated with SWAP in patients with insipient fibrosis (1446 pg/mL) compared to those without fibrosis (756.1 pg/mL; P = 0.0319). The serum levels of IL-13 and MIP-1α were higher in subjects without fibrosis than in those with moderate to severe fibrosis. However a positive association between serum levels of IL-13, TNF-α, MIP-1α, and RANTES and S. mansoni parasite burden was found. From these data we conclude that IL-5 and TNF-α may participate in liver pathology in schistosomiasis. The positive association between IL-13, TNF-α, MIP-1α, and RANTES with parasite burden, however, might predict the development of liver pathology.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-04-28T12:35:33Z No. of bitstreams: 1 Edgar M. Carvalho.pdf: 1673943 bytes, checksum: 617c22afe92e234c920f37158c709de4 (MD5)Approved for entry into archive by Alda Lima da Silva (sivalda@ufba.br) on 2014-09-11T17:55:38Z (GMT) No. of bitstreams: 1 Edgar M. Carvalho.pdf: 1673943 bytes, checksum: 617c22afe92e234c920f37158c709de4 (MD5)Made available in DSpace on 2014-09-11T17:55:38Z (GMT). No. of bitstreams: 1 Edgar M. Carvalho.pdf: 1673943 bytes, checksum: 617c22afe92e234c920f37158c709de4 (MD5) Previous issue date: 2012http://dx.doi.org/10.1155/2012/394981reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBACytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosomamansoni InfectionJournal of Parasitology Researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBrasilinfo:eu-repo/semantics/openAccessengORIGINALEdgar M. Carvalho.pdfEdgar M. 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dc.title.pt_BR.fl_str_mv Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosomamansoni Infection
dc.title.alternative.pt_BR.fl_str_mv Journal of Parasitology Research
title Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosomamansoni Infection
spellingShingle Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosomamansoni Infection
Carvalho Filho, Edgar Marcelino de
title_short Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosomamansoni Infection
title_full Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosomamansoni Infection
title_fullStr Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosomamansoni Infection
title_full_unstemmed Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosomamansoni Infection
title_sort Cytokine and Chemokine Profile in Individuals with Different Degrees of Periportal Fibrosis due to Schistosomamansoni Infection
author Carvalho Filho, Edgar Marcelino de
author_facet Carvalho Filho, Edgar Marcelino de
Oliveira, Ricardo Riccio
Araujo, Maria Ilma Andrade Santos
Souza, Robson da Paixão de
Cardoso, Luciana Santos
Lopes, Giuseppe Tittoni Varela
Almeida, Maria Cecilia Freitas de
author_role author
author2 Oliveira, Ricardo Riccio
Araujo, Maria Ilma Andrade Santos
Souza, Robson da Paixão de
Cardoso, Luciana Santos
Lopes, Giuseppe Tittoni Varela
Almeida, Maria Cecilia Freitas de
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Carvalho Filho, Edgar Marcelino de
Oliveira, Ricardo Riccio
Araujo, Maria Ilma Andrade Santos
Souza, Robson da Paixão de
Cardoso, Luciana Santos
Lopes, Giuseppe Tittoni Varela
Almeida, Maria Cecilia Freitas de
Carvalho Filho, Edgar Marcelino de
Oliveira, Ricardo Riccio
Araujo, Maria Ilma Andrade Santos
Souza, Robson da Paixão de
Cardoso, Luciana Santos
Lopes, Giuseppe Tittoni Varela
Almeida, Maria Cecilia Freitas de
description p. 1-10
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-09-11T17:55:38Z
dc.date.available.fl_str_mv 2014-09-11T17:55:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/16063
dc.identifier.issn.none.fl_str_mv 2090-0023
identifier_str_mv 2090-0023
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dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.country.fl_str_mv Brasil
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1155/2012/394981
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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