Urinary Biomarkers in Charcoal Workers Exposed to Wood Smoke in Bahia State, Brazil

Detalhes bibliográficos
Autor(a) principal: Kato, Mina
Data de Publicação: 2004
Outros Autores: Loomis, Dana P., Brooks, Lance M., Gattas, Gilka F. J., Gomes, Leni, Carvalho, Albertinho Barreto de, Rêgo, Marco Antônio Vasconcelos, DeMarini, David M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/7316
Resumo: Texto completo: acesso restrito. p. 1005–1012.
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spelling Kato, MinaLoomis, Dana P.Brooks, Lance M.Gattas, Gilka F. J.Gomes, LeniCarvalho, Albertinho Barreto deRêgo, Marco Antônio VasconcelosDeMarini, David M.Kato, MinaLoomis, Dana P.Brooks, Lance M.Gattas, Gilka F. J.Gomes, LeniCarvalho, Albertinho Barreto deRêgo, Marco Antônio VasconcelosDeMarini, David M.2012-12-07T12:22:21Z20041538-7755http://www.repositorio.ufba.br/ri/handle/ri/7316v. 13, n. 6Texto completo: acesso restrito. p. 1005–1012.Charcoal is an important source of energy for domestic and industrial use in many countries. Brazil is the largest producer of charcoal in the world, with f350,000 workers linked to the production and transportation of charcoal. To evaluate the occupational exposure to wood smoke and potential genotoxic effects on workers in charcoal production, we studied urinary mutagenicity in Salmonella YG1041 +S9 and urinary levels of 2-naphthol and 1-pyrenol in 154 workers of northeastern Bahia. Workers were classified into three categories according to their working location, and information about sociodemographic data, diet, alcohol consumption, and smoking was obtained using a standard questionnaire. Spot urine samples were collected to evaluate urinary mutagenicity and urinary metabolites. Urinary mutagenicity increased significantly with exposure to wood smoke and was modified by smoking. The prevalence odds ratio was 5.31, and the 95% confidence interval was 1.85; 15.27 for urinary mutagenicity in the highly exposed group relative to the nonexposed group. The levels of urinary metabolites increased monotonically with wood smoke exposure and were associated with the GSTM1 null genotype, which was determined previously. The prevalence odds ratio (95% confidence interval) for higher levels of 2-naphtol among the highly exposed was 17.13 (6.91; 42.44) and for 1-hydroxyprene 11.55 (5.32; 25.08) when compared with nonexposed workers. Urinary 2-naphthol was the most sensitive indicator of wood smoke exposure. This is the first reported measurement of internal exposure to wood smoke among charcoal workers, and the results showed that these workers receive a systemic exposure to genotoxic compounds.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-12-07T12:22:21Z No. of bitstreams: 1 1005.full.pdf: 234929 bytes, checksum: 6248fa3eb24bce7a4c7362bc8296f075 (MD5)Made available in DSpace on 2012-12-07T12:22:21Z (GMT). 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dc.title.pt_BR.fl_str_mv Urinary Biomarkers in Charcoal Workers Exposed to Wood Smoke in Bahia State, Brazil
dc.title.alternative.pt_BR.fl_str_mv Cancer Epidemiology, Biomarkers & Prevention
title Urinary Biomarkers in Charcoal Workers Exposed to Wood Smoke in Bahia State, Brazil
spellingShingle Urinary Biomarkers in Charcoal Workers Exposed to Wood Smoke in Bahia State, Brazil
Kato, Mina
title_short Urinary Biomarkers in Charcoal Workers Exposed to Wood Smoke in Bahia State, Brazil
title_full Urinary Biomarkers in Charcoal Workers Exposed to Wood Smoke in Bahia State, Brazil
title_fullStr Urinary Biomarkers in Charcoal Workers Exposed to Wood Smoke in Bahia State, Brazil
title_full_unstemmed Urinary Biomarkers in Charcoal Workers Exposed to Wood Smoke in Bahia State, Brazil
title_sort Urinary Biomarkers in Charcoal Workers Exposed to Wood Smoke in Bahia State, Brazil
author Kato, Mina
author_facet Kato, Mina
Loomis, Dana P.
Brooks, Lance M.
Gattas, Gilka F. J.
Gomes, Leni
Carvalho, Albertinho Barreto de
Rêgo, Marco Antônio Vasconcelos
DeMarini, David M.
author_role author
author2 Loomis, Dana P.
Brooks, Lance M.
Gattas, Gilka F. J.
Gomes, Leni
Carvalho, Albertinho Barreto de
Rêgo, Marco Antônio Vasconcelos
DeMarini, David M.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Kato, Mina
Loomis, Dana P.
Brooks, Lance M.
Gattas, Gilka F. J.
Gomes, Leni
Carvalho, Albertinho Barreto de
Rêgo, Marco Antônio Vasconcelos
DeMarini, David M.
Kato, Mina
Loomis, Dana P.
Brooks, Lance M.
Gattas, Gilka F. J.
Gomes, Leni
Carvalho, Albertinho Barreto de
Rêgo, Marco Antônio Vasconcelos
DeMarini, David M.
description Texto completo: acesso restrito. p. 1005–1012.
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2012-12-07T12:22:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7316
dc.identifier.issn.none.fl_str_mv 1538-7755
dc.identifier.number.pt_BR.fl_str_mv v. 13, n. 6
identifier_str_mv 1538-7755
v. 13, n. 6
url http://www.repositorio.ufba.br/ri/handle/ri/7316
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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