Schistosoma Antigens Downmodulate the in vitro Inflammatory Response in Individuals Infected with Human T Cell Lymphotropic Virus Type 1
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/16544 |
Resumo: | Texto completo: acesso restrito. p. 233-238 |
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Lima, Luciane MotaSantos, Silvane Maria BragaOliveira, Ricardo RiccioCardoso, Luciana SantosOliveira, Sérgio CostaGóes, Alfredo MirandaLoukas, AlexCarvalho Filho, Edgar Marcelino deAraujo, Maria Ilma Andrade SantosLima, Luciane MotaSantos, Silvane Maria BragaOliveira, Ricardo RiccioCardoso, Luciana SantosOliveira, Sérgio CostaGóes, Alfredo MirandaLoukas, AlexCarvalho Filho, Edgar Marcelino deAraujo, Maria Ilma Andrade Santos2014-11-11T17:49:58Z20131021-740http://repositorio.ufba.br/ri/handle/ri/16544v. 20, n. 4Texto completo: acesso restrito. p. 233-238Human T cell lymphotropic virus type 1 (HTLV-1) is the causal agent of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). While the immune response to HTLV-1 infection is polarized to the Th1-type, chronic helminth infections drive the Th2- and T regulatory-type, and are able to downregulate the inflammatory response in some autoimmune diseases. Objective: To evaluate whether Schistosoma spp. antigens alter the in vitro cytokine response in HTLV-1 infection. Methods: The recombinant Schistosoma antigens Sm29 and ShTSP2 (tetraspanin) and PIII, a fraction of the Schistosoma mansoni adult worm antigen were added to peripheral blood mononuclear cell (PBMC) cultures of HTLV-1-infected individuals and the levels of interferon (IFN)-γ and interleukin (IL)-10 in the supernatants were measured using the ELISA sandwich technique. Results: Compared to the levels of cytokine in nonstimulated cultures, the levels of IFN-γ were reduced in 50, 47 and 50% of patients by the presence of Sm29, ShTsp2 and PIII, respectively. The downregulation of IFN-γ production in the presence of Sm29 antigen was observed mainly in subjects who had lower basal levels of this cytokine. The levels of IL-10, however, increased by the addition of the three antigens in the cultures in 74, 62 and 44% of individuals, respectively. In addition, there was a decrease in the ratio of IFN-γ/IL-10 levels in cultures stimulated with Sm29 and ShTSP2 when compared to nonstimulated ones. Conclusions: The Schistosoma spp. antigens used in this study were able to downmodulate IFN-γ production in vitro in HTLV-1 infection. This may be associated with the increased levels of IL-10 induced by the antigens.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-11-10T11:17:21Z No. of bitstreams: 1 Luciane Mota Lima: 501434 bytes, checksum: 473a94815d8e0f7e83aa7350a1c75e21 (MD5)Approved for entry into archive by Alda Lima da Silva (sivalda@ufba.br) on 2014-11-11T17:49:58Z (GMT) No. of bitstreams: 1 Luciane Mota Lima: 501434 bytes, checksum: 473a94815d8e0f7e83aa7350a1c75e21 (MD5)Made available in DSpace on 2014-11-11T17:49:58Z (GMT). No. of bitstreams: 1 Luciane Mota Lima: 501434 bytes, checksum: 473a94815d8e0f7e83aa7350a1c75e21 (MD5) Previous issue date: 2013http://dx.doi.org/10.1159/000348700reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAHuman T cell lymphotropic virus type 1Schistosoma spp. antigensInterferon-γInterleukin-10
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| dc.title.pt_BR.fl_str_mv |
Schistosoma Antigens Downmodulate the in vitro Inflammatory Response in Individuals Infected with Human T Cell Lymphotropic Virus Type 1 |
| dc.title.alternative.pt_BR.fl_str_mv |
Neuroimmunomodulation |
| title |
Schistosoma Antigens Downmodulate the in vitro Inflammatory Response in Individuals Infected with Human T Cell Lymphotropic Virus Type 1 |
| spellingShingle |
Schistosoma Antigens Downmodulate the in vitro Inflammatory Response in Individuals Infected with Human T Cell Lymphotropic Virus Type 1 Lima, Luciane Mota Human T cell lymphotropic virus type 1 Schistosoma spp. antigens Interferon-γ Interleukin-10 |
| title_short |
Schistosoma Antigens Downmodulate the in vitro Inflammatory Response in Individuals Infected with Human T Cell Lymphotropic Virus Type 1 |
| title_full |
Schistosoma Antigens Downmodulate the in vitro Inflammatory Response in Individuals Infected with Human T Cell Lymphotropic Virus Type 1 |
| title_fullStr |
Schistosoma Antigens Downmodulate the in vitro Inflammatory Response in Individuals Infected with Human T Cell Lymphotropic Virus Type 1 |
| title_full_unstemmed |
Schistosoma Antigens Downmodulate the in vitro Inflammatory Response in Individuals Infected with Human T Cell Lymphotropic Virus Type 1 |
| title_sort |
Schistosoma Antigens Downmodulate the in vitro Inflammatory Response in Individuals Infected with Human T Cell Lymphotropic Virus Type 1 |
| author |
Lima, Luciane Mota |
| author_facet |
Lima, Luciane Mota Santos, Silvane Maria Braga Oliveira, Ricardo Riccio Cardoso, Luciana Santos Oliveira, Sérgio Costa Góes, Alfredo Miranda Loukas, Alex Carvalho Filho, Edgar Marcelino de Araujo, Maria Ilma Andrade Santos |
| author_role |
author |
| author2 |
Santos, Silvane Maria Braga Oliveira, Ricardo Riccio Cardoso, Luciana Santos Oliveira, Sérgio Costa Góes, Alfredo Miranda Loukas, Alex Carvalho Filho, Edgar Marcelino de Araujo, Maria Ilma Andrade Santos |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Lima, Luciane Mota Santos, Silvane Maria Braga Oliveira, Ricardo Riccio Cardoso, Luciana Santos Oliveira, Sérgio Costa Góes, Alfredo Miranda Loukas, Alex Carvalho Filho, Edgar Marcelino de Araujo, Maria Ilma Andrade Santos Lima, Luciane Mota Santos, Silvane Maria Braga Oliveira, Ricardo Riccio Cardoso, Luciana Santos Oliveira, Sérgio Costa Góes, Alfredo Miranda Loukas, Alex Carvalho Filho, Edgar Marcelino de Araujo, Maria Ilma Andrade Santos |
| dc.subject.por.fl_str_mv |
Human T cell lymphotropic virus type 1 Schistosoma spp. antigens Interferon-γ Interleukin-10 |
| topic |
Human T cell lymphotropic virus type 1 Schistosoma spp. antigens Interferon-γ Interleukin-10 |
| description |
Texto completo: acesso restrito. p. 233-238 |
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2013 |
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2013 |
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2014-11-11T17:49:58Z |
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info:eu-repo/semantics/publishedVersion |
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1021-740 |
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v. 20, n. 4 |
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1021-740 v. 20, n. 4 |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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