Evaluation of the hepatotoxicity of Abarema cochliacarpos extracts in mice Mus musculus
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/15110 |
Resumo: | p. 674-679 |
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Oliveira, Roseli F.Ribeiro, Paulo R.Santos, Getisêmani K. M.Oliveira, Claudenice S.Silva, Pompilio R. C.Oliveira, Hiagno A.Trindade, Rita de C.Fernandez, Luzimar GonzagaOliveira, Roseli F.Ribeiro, Paulo R.Santos, Getisêmani K. M.Oliveira, Claudenice S.Silva, Pompilio R. C.Oliveira, Hiagno A.Trindade, Rita de C.Fernandez, Luzimar Gonzaga2014-07-04T13:23:51Z2014-07-04T13:23:51Z20130102-695Xhttp://repositorio.ufba.br/ri/handle/ri/15110v. 23, n. 4p. 674-679Abarema cochliacarpos (Gomes) Barneby & J.W. Grimes, Fabaceae, is a native species of Brazil popularly known as "barbatimão", frequently found along the north coast of the state of Bahia. Local communities make an infusion from its stem bark, which is used to treat several diseases. This study aimed to evaluate the hepatotoxicity of A. cochliacarpos extracts in mice Mus musculus. The bark infusion and hydroalcoholic extract were administered nasogastrically into two groups of eight animals (four male and four female each). After 45 days all mice were killed and the livers were collected for further histological analysis. Hepatic steatosis, congestion of the hepatic vessels and medicinal plantspresence of macrophages and lymphocytes infiltrates in the liver, were observed in both steatosis group of animals, additionally animals that received the stem bark infusion presented an accumulation of pigments. None of the animals belonging to the negative control group showed any of the symptoms described above. In conclusion, the hydroalcoholic extract and infusion of A. cochliacarpos stem bark were proven to cause intoxication in mice. The hepatotoxicity of the infusion was more aggressive in females. Further studies are necessary to isolate compounds responsible for the toxic characteristics of A. cochliacarpos.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-05-13T15:22:33Z No. of bitstreams: 1 10.1590-S0102-695X2013005000052.pdf: 3298785 bytes, checksum: dcf62112900c6712cb599cf23848a57e (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-07-04T13:23:51Z (GMT) No. of bitstreams: 1 10.1590-S0102-695X2013005000052.pdf: 3298785 bytes, checksum: dcf62112900c6712cb599cf23848a57e (MD5)Made available in DSpace on 2014-07-04T13:23:51Z (GMT). No. of bitstreams: 1 10.1590-S0102-695X2013005000052.pdf: 3298785 bytes, checksum: dcf62112900c6712cb599cf23848a57e (MD5) Previous issue date: 2013http://dx.doi.org/10.1590/S0102-695X2013005000052reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAAbarema cochliacarposBarbatimãoCepatic congestionMedical plantsSteatosisEvaluation of the hepatotoxicity of Abarema cochliacarpos extracts in mice Mus musculusRevista Brasileira de Farmacognosiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessengORIGINAL10.1590-S0102-695X2013005000052.pdf10.1590-S0102-695X2013005000052.pdfapplication/pdf3298785https://repositorio.ufba.br/bitstream/ri/15110/1/10.1590-S0102-695X2013005000052.pdfdcf62112900c6712cb599cf23848a57eMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/15110/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52TEXT10.1590-S0102-695X2013005000052.pdf.txt10.1590-S0102-695X2013005000052.pdf.txtExtracted texttext/plain23116https://repositorio.ufba.br/bitstream/ri/15110/3/10.1590-S0102-695X2013005000052.pdf.txt3607517676d006525771ec810e485150MD53ri/151102022-07-05 14:03:31.633oai:repositorio.ufba.br:ri/15110VGVybW8gZGUgTGljZW4/YSwgbj9vIGV4Y2x1c2l2bywgcGFyYSBvIGRlcD9zaXRvIG5vIFJlcG9zaXQ/cmlvIEluc3RpdHVjaW9uYWwgZGEgVUZCQS4KCiBQZWxvIHByb2Nlc3NvIGRlIHN1Ym1pc3M/byBkZSBkb2N1bWVudG9zLCBvIGF1dG9yIG91IHNldSByZXByZXNlbnRhbnRlIGxlZ2FsLCBhbyBhY2VpdGFyIAplc3NlIHRlcm1vIGRlIGxpY2VuP2EsIGNvbmNlZGUgYW8gUmVwb3NpdD9yaW8gSW5zdGl0dWNpb25hbCBkYSBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkYSBCYWhpYSAKbyBkaXJlaXRvIGRlIG1hbnRlciB1bWEgYz9waWEgZW0gc2V1IHJlcG9zaXQ/cmlvIGNvbSBhIGZpbmFsaWRhZGUsIHByaW1laXJhLCBkZSBwcmVzZXJ2YT8/by4gCkVzc2VzIHRlcm1vcywgbj9vIGV4Y2x1c2l2b3MsIG1hbnQ/bSBvcyBkaXJlaXRvcyBkZSBhdXRvci9jb3B5cmlnaHQsIG1hcyBlbnRlbmRlIG8gZG9jdW1lbnRvIApjb21vIHBhcnRlIGRvIGFjZXJ2byBpbnRlbGVjdHVhbCBkZXNzYSBVbml2ZXJzaWRhZGUuCgogUGFyYSBvcyBkb2N1bWVudG9zIHB1YmxpY2Fkb3MgY29tIHJlcGFzc2UgZGUgZGlyZWl0b3MgZGUgZGlzdHJpYnVpPz9vLCBlc3NlIHRlcm1vIGRlIGxpY2VuP2EgCmVudGVuZGUgcXVlOgoKIE1hbnRlbmRvIG9zIGRpcmVpdG9zIGF1dG9yYWlzLCByZXBhc3NhZG9zIGEgdGVyY2Vpcm9zLCBlbSBjYXNvIGRlIHB1YmxpY2E/P2VzLCBvIHJlcG9zaXQ/cmlvCnBvZGUgcmVzdHJpbmdpciBvIGFjZXNzbyBhbyB0ZXh0byBpbnRlZ3JhbCwgbWFzIGxpYmVyYSBhcyBpbmZvcm1hPz9lcyBzb2JyZSBvIGRvY3VtZW50bwooTWV0YWRhZG9zIGVzY3JpdGl2b3MpLgoKIERlc3RhIGZvcm1hLCBhdGVuZGVuZG8gYW9zIGFuc2Vpb3MgZGVzc2EgdW5pdmVyc2lkYWRlIGVtIG1hbnRlciBzdWEgcHJvZHU/P28gY2llbnQ/ZmljYSBjb20gCmFzIHJlc3RyaT8/ZXMgaW1wb3N0YXMgcGVsb3MgZWRpdG9yZXMgZGUgcGVyaT9kaWNvcy4KCiBQYXJhIGFzIHB1YmxpY2E/P2VzIHNlbSBpbmljaWF0aXZhcyBxdWUgc2VndWVtIGEgcG9sP3RpY2EgZGUgQWNlc3NvIEFiZXJ0bywgb3MgZGVwP3NpdG9zIApjb21wdWxzP3Jpb3MgbmVzc2UgcmVwb3NpdD9yaW8gbWFudD9tIG9zIGRpcmVpdG9zIGF1dG9yYWlzLCBtYXMgbWFudD9tIGFjZXNzbyBpcnJlc3RyaXRvIAphbyBtZXRhZGFkb3MgZSB0ZXh0byBjb21wbGV0by4gQXNzaW0sIGEgYWNlaXRhPz9vIGRlc3NlIHRlcm1vIG4/byBuZWNlc3NpdGEgZGUgY29uc2VudGltZW50bwogcG9yIHBhcnRlIGRlIGF1dG9yZXMvZGV0ZW50b3JlcyBkb3MgZGlyZWl0b3MsIHBvciBlc3RhcmVtIGVtIGluaWNpYXRpdmFzIGRlIGFjZXNzbyBhYmVydG8uCg==Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:31Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Evaluation of the hepatotoxicity of Abarema cochliacarpos extracts in mice Mus musculus |
dc.title.alternative.pt_BR.fl_str_mv |
Revista Brasileira de Farmacognosia |
title |
Evaluation of the hepatotoxicity of Abarema cochliacarpos extracts in mice Mus musculus |
spellingShingle |
Evaluation of the hepatotoxicity of Abarema cochliacarpos extracts in mice Mus musculus Oliveira, Roseli F. Abarema cochliacarpos Barbatimão Cepatic congestion Medical plants Steatosis |
title_short |
Evaluation of the hepatotoxicity of Abarema cochliacarpos extracts in mice Mus musculus |
title_full |
Evaluation of the hepatotoxicity of Abarema cochliacarpos extracts in mice Mus musculus |
title_fullStr |
Evaluation of the hepatotoxicity of Abarema cochliacarpos extracts in mice Mus musculus |
title_full_unstemmed |
Evaluation of the hepatotoxicity of Abarema cochliacarpos extracts in mice Mus musculus |
title_sort |
Evaluation of the hepatotoxicity of Abarema cochliacarpos extracts in mice Mus musculus |
author |
Oliveira, Roseli F. |
author_facet |
Oliveira, Roseli F. Ribeiro, Paulo R. Santos, Getisêmani K. M. Oliveira, Claudenice S. Silva, Pompilio R. C. Oliveira, Hiagno A. Trindade, Rita de C. Fernandez, Luzimar Gonzaga |
author_role |
author |
author2 |
Ribeiro, Paulo R. Santos, Getisêmani K. M. Oliveira, Claudenice S. Silva, Pompilio R. C. Oliveira, Hiagno A. Trindade, Rita de C. Fernandez, Luzimar Gonzaga |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Oliveira, Roseli F. Ribeiro, Paulo R. Santos, Getisêmani K. M. Oliveira, Claudenice S. Silva, Pompilio R. C. Oliveira, Hiagno A. Trindade, Rita de C. Fernandez, Luzimar Gonzaga Oliveira, Roseli F. Ribeiro, Paulo R. Santos, Getisêmani K. M. Oliveira, Claudenice S. Silva, Pompilio R. C. Oliveira, Hiagno A. Trindade, Rita de C. Fernandez, Luzimar Gonzaga |
dc.subject.por.fl_str_mv |
Abarema cochliacarpos Barbatimão Cepatic congestion Medical plants Steatosis |
topic |
Abarema cochliacarpos Barbatimão Cepatic congestion Medical plants Steatosis |
description |
p. 674-679 |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013 |
dc.date.accessioned.fl_str_mv |
2014-07-04T13:23:51Z |
dc.date.available.fl_str_mv |
2014-07-04T13:23:51Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
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http://repositorio.ufba.br/ri/handle/ri/15110 |
dc.identifier.issn.none.fl_str_mv |
0102-695X |
dc.identifier.number.pt_BR.fl_str_mv |
v. 23, n. 4 |
identifier_str_mv |
0102-695X v. 23, n. 4 |
url |
http://repositorio.ufba.br/ri/handle/ri/15110 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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http://dx.doi.org/10.1590/S0102-695X2013005000052 |
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