Immunochemotherapy with interferon-γ and multidrug therapy for multibacillary leprosy
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 1999 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/13407 |
Resumo: | Texto completo. Acesso restrito. p. 185–201 |
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Barral-Netto, ManoelSantos, S.Santos, I.Sohsten, R. L. VonBittencourt, Achilea Candida LisboaCarvalho Filho, Edgar Marcelino deBarral, Aldina Maria PradoWaters, M.Barral-Netto, ManoelSantos, S.Santos, I.Sohsten, R. L. VonBittencourt, Achilea Candida LisboaCarvalho Filho, Edgar Marcelino deBarral, Aldina Maria PradoWaters, M.2013-10-31T17:46:57Z19990001-706Xhttp://repositorio.ufba.br/ri/handle/ri/13407v. 72, n. 2Texto completo. Acesso restrito. p. 185–201Treatment for multibacillary leprosy is presently performed with a multidrug therapy (MDT) scheme maintained for 2 years. Leprosy treatment however can benefit from the reduction of length. The lack of interferon-γ (IFN-γ) production by lepromatous leprosy (LL) patients’ lymphocytes lead us to use this cytokine in the treatment of multibacillary leprosy associated with MDT in the treatment of multibacillary leprosy, and monitor several clinical and immunological parameters during the course of treatment. A total of 20 multibacillary leprosy patients were evaluated, 10 treated with MDT alone, and 10 treated with MDT+10 daily doses of 2×106 international units (IU) of recombinant human IFN-γ/m2 followed by 10 daily doses of 107 IU IFN-γ/m2, intramuscularly, during the first 20 days of MDT. IFN-γ was well tolerated and did not cause any increase in the rate of leprosy reactions development during treatment. Decrease of bacillary load, fall of anti-Mycobacterium leprae IgG serum antibodies, changes of histological pattern, as well as changes in lymphocyte proliferation assay in response to mitogens (PHA or PWM), M. leprae antigen or PPD was similar in both groups of patients. Among several soluble immunological markers measured before and 30 days after beginning of treatment, levels of soluble IL-2R receptor increased in patients treated with MDT plus IFN-γ whereas decreased in patients treated with MDT alone. Soluble ICAM-1 levels decreased in the MDT group but did not change in the MDT+IFN-γ treated patients. Soluble CD4 and soluble CD8 markers did not change significantly in either group of patients. Neopterin, a marker of macrophage activation, increased in all but one patient treated with MDT+IFN-γ but in none treated with MDT alone, indicating that IFN-γ was active in vivo. Our findings indicate that despite being able to promote macrophage activation in multibacillary leprosy patients a short course of systemically administered IFN-γ is not able to change the clinical course of a long standing disease such as leprosy.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-08-08T19:10:04Z No. of bitstreams: 1 33333333333333.pdf: 156070 bytes, checksum: 823b4dad01937db1d16063b5ebe6f264 (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-10-31T17:46:57Z (GMT) No. of bitstreams: 1 33333333333333.pdf: 156070 bytes, checksum: 823b4dad01937db1d16063b5ebe6f264 (MD5)Made available in DSpace on 2013-10-31T17:46:57Z (GMT). No. of bitstreams: 1 33333333333333.pdf: 156070 bytes, checksum: 823b4dad01937db1d16063b5ebe6f264 (MD5) Previous issue date: 1999SalvadorActa Tropicahttp://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/S0001-706X(98)00097-7reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBALeprosyMultibacillary leprosyInterferon-γMulti-drug therapyImmunochemotherapyImmunochemotherapy with interferon-γ and multidrug therapy for multibacillary leprosyActa Tropicainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL33333333333333.pdf33333333333333.pdfapplication/pdf156070https://repositorio.ufba.br/bitstream/ri/13407/1/33333333333333.pdf823b4dad01937db1d16063b5ebe6f264MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/13407/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT33333333333333.pdf.txt33333333333333.pdf.txtExtracted texttext/plain42902https://repositorio.ufba.br/bitstream/ri/13407/3/33333333333333.pdf.txt3a72e7613e951e0d967a81211311f657MD53ri/134072022-08-08 13:17:35.918oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:17:35Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Immunochemotherapy with interferon-γ and multidrug therapy for multibacillary leprosy |
| dc.title.alternative.pt_BR.fl_str_mv |
Acta Tropica |
| title |
Immunochemotherapy with interferon-γ and multidrug therapy for multibacillary leprosy |
| spellingShingle |
Immunochemotherapy with interferon-γ and multidrug therapy for multibacillary leprosy Barral-Netto, Manoel Leprosy Multibacillary leprosy Interferon-γ Multi-drug therapy Immunochemotherapy |
| title_short |
Immunochemotherapy with interferon-γ and multidrug therapy for multibacillary leprosy |
| title_full |
Immunochemotherapy with interferon-γ and multidrug therapy for multibacillary leprosy |
| title_fullStr |
Immunochemotherapy with interferon-γ and multidrug therapy for multibacillary leprosy |
| title_full_unstemmed |
Immunochemotherapy with interferon-γ and multidrug therapy for multibacillary leprosy |
| title_sort |
Immunochemotherapy with interferon-γ and multidrug therapy for multibacillary leprosy |
| author |
Barral-Netto, Manoel |
| author_facet |
Barral-Netto, Manoel Santos, S. Santos, I. Sohsten, R. L. Von Bittencourt, Achilea Candida Lisboa Carvalho Filho, Edgar Marcelino de Barral, Aldina Maria Prado Waters, M. |
| author_role |
author |
| author2 |
Santos, S. Santos, I. Sohsten, R. L. Von Bittencourt, Achilea Candida Lisboa Carvalho Filho, Edgar Marcelino de Barral, Aldina Maria Prado Waters, M. |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Barral-Netto, Manoel Santos, S. Santos, I. Sohsten, R. L. Von Bittencourt, Achilea Candida Lisboa Carvalho Filho, Edgar Marcelino de Barral, Aldina Maria Prado Waters, M. Barral-Netto, Manoel Santos, S. Santos, I. Sohsten, R. L. Von Bittencourt, Achilea Candida Lisboa Carvalho Filho, Edgar Marcelino de Barral, Aldina Maria Prado Waters, M. |
| dc.subject.por.fl_str_mv |
Leprosy Multibacillary leprosy Interferon-γ Multi-drug therapy Immunochemotherapy |
| topic |
Leprosy Multibacillary leprosy Interferon-γ Multi-drug therapy Immunochemotherapy |
| description |
Texto completo. Acesso restrito. p. 185–201 |
| publishDate |
1999 |
| dc.date.issued.fl_str_mv |
1999 |
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2013-10-31T17:46:57Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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http://repositorio.ufba.br/ri/handle/ri/13407 |
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0001-706X |
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v. 72, n. 2 |
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0001-706X v. 72, n. 2 |
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Acta Tropica |
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Acta Tropica |
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