Enhanced Leishmania braziliensis infection following pre-exposure to sandfly saliva

Detalhes bibliográficos
Autor(a) principal: Moura, Tatiana Rodrigues de
Data de Publicação: 2007
Outros Autores: Oliveira, Fabiano, Novais, Fernanda O., Miranda, José Carlos, Clarêncio, Jorge, Follador, Ivonise, Carvalho Filho, Edgar Marcelino de, Valenzuela, Jesus G., Barral-Netto, Manoel, Barral, Aldina Maria Prado, Brodskyn, Claudia Ida, Oliveira, Camila Indiani de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/14314
Resumo: p. 1-10
id UFBA-2_edb66f5a32f09382aea8c47548dd2956
oai_identifier_str oai:repositorio.ufba.br:ri/14314
network_acronym_str UFBA-2
network_name_str Repositório Institucional da UFBA
repository_id_str 1932
spelling Moura, Tatiana Rodrigues deOliveira, FabianoNovais, Fernanda O.Miranda, José CarlosClarêncio, JorgeFollador, IvoniseCarvalho Filho, Edgar Marcelino deValenzuela, Jesus G.Barral-Netto, ManoelBarral, Aldina Maria PradoBrodskyn, Claudia IdaOliveira, Camila Indiani de2014-01-10T16:33:53Z2014-01-10T16:33:53Z20071935-2727http://repositorio.ufba.br/ri/handle/ri/14314v. 1, n. 2p. 1-10Background: Sand fly saliva has an array of pharmacological and immunomodulatory components, and immunity to saliva protects against Leishmania infection. In the present study, we have studied the immune response against Lutzomyia intermedia saliva, the main vector of Leishmania braziliensis in Brazil, and the effects of saliva pre-exposure on L. braziliensis infection employing an intradermal experimental model. Methodology/principal findings: BALB/c mice immunized with L. intermedia salivary gland sonicate (SGS) developed a saliva-specific antibody response and a cellular immune response with presence of both IFN-γ and IL-4. The inflammatory infiltrate observed in SGS-immunized mice was comprised of numerous polymorphonuclear and few mononuclear cells. Mice challenged with live L. braziliensis in the presence of saliva were not protected although lesion development was delayed. The inoculation site and draining lymph node showed continuous parasite replication and low IFN-γ to IL-4 ratio, indicating that pre-exposure to L. intermedia saliva leads to modulation of the immune response. Furthermore, in an endemic area of cutaneous leishmaniasis, patients with active lesions displayed higher levels of anti-L. intermedia saliva antibodies when compared to individuals with a positive skin test result for Leishmania. Conclusion: These results show that pre-exposure to sand fly saliva plays an important role in the outcome of cutaneous leishmaniasis, in both mice and humans. They emphasize possible hurdles in the development of vaccines based on sand fly saliva and the need to identify and select the individual salivary candidates instead of using whole salivary mixture that may favor a non-protective response.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-01-08T13:08:22Z No. of bitstreams: 1 journal.pntd.0000084.pdf: 1019025 bytes, checksum: 71900033d3c58346ec845b6c7211cb0a (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-01-10T16:33:53Z (GMT) No. of bitstreams: 1 journal.pntd.0000084.pdf: 1019025 bytes, checksum: 71900033d3c58346ec845b6c7211cb0a (MD5)Made available in DSpace on 2014-01-10T16:33:53Z (GMT). No. of bitstreams: 1 journal.pntd.0000084.pdf: 1019025 bytes, checksum: 71900033d3c58346ec845b6c7211cb0a (MD5) Previous issue date: 2007http://dx.doi.org/10.1371/journal.pntd.0000084reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBALeishmania braziliensisSalivaLeishmania - ImmunologyEnhanced Leishmania braziliensis infection following pre-exposure to sandfly salivaPLoS Neglected Tropical Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBrasilinfo:eu-repo/semantics/openAccessengORIGINALjournal.pntd.0000084.pdfjournal.pntd.0000084.pdfapplication/pdf1019025https://repositorio.ufba.br/bitstream/ri/14314/1/journal.pntd.0000084.pdf71900033d3c58346ec845b6c7211cb0aMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/14314/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTjournal.pntd.0000084.pdf.txtjournal.pntd.0000084.pdf.txtExtracted texttext/plain49231https://repositorio.ufba.br/bitstream/ri/14314/3/journal.pntd.0000084.pdf.txt9175467d9c23a734870c61dae5941019MD53ri/143142022-03-10 13:54:23.33oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-03-10T16:54:23Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Enhanced Leishmania braziliensis infection following pre-exposure to sandfly saliva
dc.title.alternative.pt_BR.fl_str_mv PLoS Neglected Tropical Diseases
title Enhanced Leishmania braziliensis infection following pre-exposure to sandfly saliva
spellingShingle Enhanced Leishmania braziliensis infection following pre-exposure to sandfly saliva
Moura, Tatiana Rodrigues de
Leishmania braziliensis
Saliva
Leishmania - Immunology
title_short Enhanced Leishmania braziliensis infection following pre-exposure to sandfly saliva
title_full Enhanced Leishmania braziliensis infection following pre-exposure to sandfly saliva
title_fullStr Enhanced Leishmania braziliensis infection following pre-exposure to sandfly saliva
title_full_unstemmed Enhanced Leishmania braziliensis infection following pre-exposure to sandfly saliva
title_sort Enhanced Leishmania braziliensis infection following pre-exposure to sandfly saliva
author Moura, Tatiana Rodrigues de
author_facet Moura, Tatiana Rodrigues de
Oliveira, Fabiano
Novais, Fernanda O.
Miranda, José Carlos
Clarêncio, Jorge
Follador, Ivonise
Carvalho Filho, Edgar Marcelino de
Valenzuela, Jesus G.
Barral-Netto, Manoel
Barral, Aldina Maria Prado
Brodskyn, Claudia Ida
Oliveira, Camila Indiani de
author_role author
author2 Oliveira, Fabiano
Novais, Fernanda O.
Miranda, José Carlos
Clarêncio, Jorge
Follador, Ivonise
Carvalho Filho, Edgar Marcelino de
Valenzuela, Jesus G.
Barral-Netto, Manoel
Barral, Aldina Maria Prado
Brodskyn, Claudia Ida
Oliveira, Camila Indiani de
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Moura, Tatiana Rodrigues de
Oliveira, Fabiano
Novais, Fernanda O.
Miranda, José Carlos
Clarêncio, Jorge
Follador, Ivonise
Carvalho Filho, Edgar Marcelino de
Valenzuela, Jesus G.
Barral-Netto, Manoel
Barral, Aldina Maria Prado
Brodskyn, Claudia Ida
Oliveira, Camila Indiani de
dc.subject.por.fl_str_mv Leishmania braziliensis
Saliva
Leishmania - Immunology
topic Leishmania braziliensis
Saliva
Leishmania - Immunology
description p. 1-10
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2014-01-10T16:33:53Z
dc.date.available.fl_str_mv 2014-01-10T16:33:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/14314
dc.identifier.issn.none.fl_str_mv 1935-2727
dc.identifier.number.pt_BR.fl_str_mv v. 1, n. 2
identifier_str_mv 1935-2727
v. 1, n. 2
url http://repositorio.ufba.br/ri/handle/ri/14314
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.country.fl_str_mv Brasil
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1371/journal.pntd.0000084
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
bitstream.url.fl_str_mv https://repositorio.ufba.br/bitstream/ri/14314/1/journal.pntd.0000084.pdf
https://repositorio.ufba.br/bitstream/ri/14314/2/license.txt
https://repositorio.ufba.br/bitstream/ri/14314/3/journal.pntd.0000084.pdf.txt
bitstream.checksum.fl_str_mv 71900033d3c58346ec845b6c7211cb0a
ff6eaa8b858ea317fded99f125f5fcd0
9175467d9c23a734870c61dae5941019
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)
repository.mail.fl_str_mv
_version_ 1808459468549128192

Registros relacionados