Enhanced Leishmania braziliensis infection following pre-exposure to sandfly saliva
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2007 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/2765 |
Resumo: | Este trabalho foi financiado com recursos da FAPESB, PAPES/FIOCRUZ e CNPq. |
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Moura, Tatiana Rodrigues deOliveira, FabianoNovais, Fernanda OliveiraMiranda, José CarlosClarêncio, JorgeFollador, IvoniseCarvalho Filho, Edgar MarcelinoValenzuela, Jesus GBarral Netto, ManoelBarral, Aldina Maria PradoBrodskyn, Claudia IdaOliveira, Camila Indiani de2011-07-20T14:53:04Z2011-07-20T14:53:04Z2007MOURA, T. R. de et al. Enhanced Leishmania braziliensis infection following pre-exposure to sandfly saliva. PLos Neglected Tropical Diseases, v.1, n.2, p.1-10, 2007.1935-2727https://www.arca.fiocruz.br/handle/icict/276510.1371/journal.pntd.0000084Este trabalho foi financiado com recursos da FAPESB, PAPES/FIOCRUZ e CNPq.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / National Institute of Allergy and Infectious Diseases. National Institutes of Health. Vector Molecular Biology Unit. Rockville, MD, United States of America.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal da Bahia. Salvador, BA, Brasil.Universidade Federal da Bahia. Salvador, BA, Brasil.National Institute of Allergy and Infectious Diseases. National Institutes of Health. Vector Molecular Biology Unit. Rockville, MD, USA.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Background: Sand fly saliva has an array of pharmacological and immunomodulatory components, and immunity to saliva protects against Leishmania infection. In the present study, we have studied the immune response against Lutzomyia intermedia saliva, the main vector of Leishmania braziliensis in Brazil, and the effects of saliva pre-exposure on L. braziliensis infection employing an intradermal experimental model. Methodology/principal findings: BALB/c mice immunized with L. intermedia salivary gland sonicate (SGS) developed a saliva-specific antibody response and a cellular immune response with presence of both IFN-c and IL-4. The inflammatory infiltrate observed in SGS-immunized mice was comprised of numerous polymorphonuclear and few mononuclear cells. Mice challenged with live L. braziliensis in the presence of saliva were not protected although lesion development was delayed. The inoculation site and draining lymph node showed continuous parasite replication and low IFN-c to IL-4 ratio, indicating that pre-exposure to L. intermedia saliva leads to modulation of the immune response. Furthermore, in an endemic area of cutaneous leishmaniasis, patients with active lesions displayed higher levels of anti-L. intermedia saliva antibodies when compared to individuals with a positive skin test result for Leishmania. Conclusion: These results show that pre-exposure to sand fly saliva plays an important role in the outcome of cutaneous leishmaniasis, in both mice and humans. They emphasize possible hurdles in the development of vaccines based on sand fly saliva and the need to identify and select the individual salivary candidates instead of using whole salivary mixture that may favor a non-protective response.engPublic Library of ScienceLeishmania braziliensisInfecçãoSalivaFlebotomíneosLeishmania braziliensisInfectionSalivaSandflyLeishmania braziliensisInfecçãoSalivaDípterosEnhanced Leishmania braziliensis infection following pre-exposure to sandfly salivainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALMoura_Oliveira_Novais_etal.pdfMoura_Oliveira_Novais_etal.pdfapplication/pdf1012054https://www.arca.fiocruz.br/bitstream/icict/2765/1/Moura_Oliveira_Novais_etal.pdffd278e805d64d8311ba4d2571b4928a8MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/2765/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTMoura_Oliveira_Novais_etal.pdf.txtMoura_Oliveira_Novais_etal.pdf.txtExtracted texttext/plain49231https://www.arca.fiocruz.br/bitstream/icict/2765/5/Moura_Oliveira_Novais_etal.pdf.txt9175467d9c23a734870c61dae5941019MD55THUMBNAILMoura_Oliveira_Novais_etal.pdf.jpgMoura_Oliveira_Novais_etal.pdf.jpgGenerated Thumbnailimage/jpeg2202https://www.arca.fiocruz.br/bitstream/icict/2765/4/Moura_Oliveira_Novais_etal.pdf.jpg24c1bc0df0a76b472113c69fe72ef675MD54icict/27652023-03-15 14:34:09.315oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:09Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Enhanced Leishmania braziliensis infection following pre-exposure to sandfly saliva |
| title |
Enhanced Leishmania braziliensis infection following pre-exposure to sandfly saliva |
| spellingShingle |
Enhanced Leishmania braziliensis infection following pre-exposure to sandfly saliva Moura, Tatiana Rodrigues de Leishmania braziliensis Infecção Saliva Flebotomíneos Leishmania braziliensis Infection Saliva Sandfly Leishmania braziliensis Infecção Saliva Dípteros |
| title_short |
Enhanced Leishmania braziliensis infection following pre-exposure to sandfly saliva |
| title_full |
Enhanced Leishmania braziliensis infection following pre-exposure to sandfly saliva |
| title_fullStr |
Enhanced Leishmania braziliensis infection following pre-exposure to sandfly saliva |
| title_full_unstemmed |
Enhanced Leishmania braziliensis infection following pre-exposure to sandfly saliva |
| title_sort |
Enhanced Leishmania braziliensis infection following pre-exposure to sandfly saliva |
| author |
Moura, Tatiana Rodrigues de |
| author_facet |
Moura, Tatiana Rodrigues de Oliveira, Fabiano Novais, Fernanda Oliveira Miranda, José Carlos Clarêncio, Jorge Follador, Ivonise Carvalho Filho, Edgar Marcelino Valenzuela, Jesus G Barral Netto, Manoel Barral, Aldina Maria Prado Brodskyn, Claudia Ida Oliveira, Camila Indiani de |
| author_role |
author |
| author2 |
Oliveira, Fabiano Novais, Fernanda Oliveira Miranda, José Carlos Clarêncio, Jorge Follador, Ivonise Carvalho Filho, Edgar Marcelino Valenzuela, Jesus G Barral Netto, Manoel Barral, Aldina Maria Prado Brodskyn, Claudia Ida Oliveira, Camila Indiani de |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Moura, Tatiana Rodrigues de Oliveira, Fabiano Novais, Fernanda Oliveira Miranda, José Carlos Clarêncio, Jorge Follador, Ivonise Carvalho Filho, Edgar Marcelino Valenzuela, Jesus G Barral Netto, Manoel Barral, Aldina Maria Prado Brodskyn, Claudia Ida Oliveira, Camila Indiani de |
| dc.subject.other.pt_BR.fl_str_mv |
Leishmania braziliensis Infecção Saliva Flebotomíneos |
| topic |
Leishmania braziliensis Infecção Saliva Flebotomíneos Leishmania braziliensis Infection Saliva Sandfly Leishmania braziliensis Infecção Saliva Dípteros |
| dc.subject.en.pt_BR.fl_str_mv |
Leishmania braziliensis Infection Saliva Sandfly |
| dc.subject.decs.pt_BR.fl_str_mv |
Leishmania braziliensis Infecção Saliva Dípteros |
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Este trabalho foi financiado com recursos da FAPESB, PAPES/FIOCRUZ e CNPq. |
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2007 |
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2007 |
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2011-07-20T14:53:04Z |
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2011-07-20T14:53:04Z |
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MOURA, T. R. de et al. Enhanced Leishmania braziliensis infection following pre-exposure to sandfly saliva. PLos Neglected Tropical Diseases, v.1, n.2, p.1-10, 2007. |
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10.1371/journal.pntd.0000084 |
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MOURA, T. R. de et al. Enhanced Leishmania braziliensis infection following pre-exposure to sandfly saliva. PLos Neglected Tropical Diseases, v.1, n.2, p.1-10, 2007. 1935-2727 10.1371/journal.pntd.0000084 |
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