Impact of apolipoprotein E genetic polymorphisms on liver disease: an essential review

Detalhes bibliográficos
Autor(a) principal: Nascimento, José Carlos Rodrigues
Data de Publicação: 2020
Outros Autores: Matos, Gabriella A., Pereira, Lianna C., Mourão, Anderson E.C.C.B., Sampaio, Aline M., Oriá, Reinaldo B., Toniuttoc, Pierluigi
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
dARK ID: ark:/83112/00130000075xz
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/57881
Resumo: Cirrhosis is an advanced stage of liver disease, compromising liver function with systemic health implications and poor quality of life. Hepatitis C virus (HCV) infection and alcoholic liver disease are the main causes of this pathology. However, since genetic factors may play a large role in the progression and severity of liver disease, and as apolipoprotein E (apoE) has been recognised to be mainly synthesised in the liver, apoE polymorphism studies are important to better understand the causal mechanisms in liver diseases. In this review, we summarise up-to-date studies addressing how apoE polymorphisms influence liver cirrhosis and liver transplantation outcomes and potential protective mechanisms. Although more clinical studies are needed to support these findings, the apoE 4 allele seems to be protective against the progression of liver cirrhosis in the majority of aetiologies and the postoperative serum apoE phenotype of the transplanted subject receptors was converted to that of the donor, indicating that >90% of apoE in plasma is synthesised in the hepatic system.
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spelling Impact of apolipoprotein E genetic polymorphisms on liver disease: an essential reviewApolipoproteínas EApolipoprotein ELiver cirrhosisCirrose HepáticaLiver diseasesHepatopatiasLiver transplantationTransplante de FígadoCirrhosis is an advanced stage of liver disease, compromising liver function with systemic health implications and poor quality of life. Hepatitis C virus (HCV) infection and alcoholic liver disease are the main causes of this pathology. However, since genetic factors may play a large role in the progression and severity of liver disease, and as apolipoprotein E (apoE) has been recognised to be mainly synthesised in the liver, apoE polymorphism studies are important to better understand the causal mechanisms in liver diseases. In this review, we summarise up-to-date studies addressing how apoE polymorphisms influence liver cirrhosis and liver transplantation outcomes and potential protective mechanisms. Although more clinical studies are needed to support these findings, the apoE 4 allele seems to be protective against the progression of liver cirrhosis in the majority of aetiologies and the postoperative serum apoE phenotype of the transplanted subject receptors was converted to that of the donor, indicating that >90% of apoE in plasma is synthesised in the hepatic system.Annals of Hepatology2021-04-20T18:44:37Z2021-04-20T18:44:37Z2020-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfNASCIMENTO, J. C. R. et al. Impact of apolipoprotein E genetic polymorphisms on liver disease: An essential review. Annals of Hepatology, v. 19, n. 1, p. 24-30, 2020. Disponível em: https://www.sciencedirect.com/science/article/pii/S1665268119322185?via%3Dihub. Acesso em: 20 abr. 2021.1665-2681http://www.repositorio.ufc.br/handle/riufc/57881ark:/83112/00130000075xzNascimento, José Carlos RodriguesMatos, Gabriella A.Pereira, Lianna C.Mourão, Anderson E.C.C.B.Sampaio, Aline M.Oriá, Reinaldo B.Toniuttoc, Pierluigiengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2023-08-25T23:02:55Zoai:repositorio.ufc.br:riufc/57881Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:33:26.433844Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Impact of apolipoprotein E genetic polymorphisms on liver disease: an essential review
title Impact of apolipoprotein E genetic polymorphisms on liver disease: an essential review
spellingShingle Impact of apolipoprotein E genetic polymorphisms on liver disease: an essential review
Nascimento, José Carlos Rodrigues
Apolipoproteínas E
Apolipoprotein E
Liver cirrhosis
Cirrose Hepática
Liver diseases
Hepatopatias
Liver transplantation
Transplante de Fígado
title_short Impact of apolipoprotein E genetic polymorphisms on liver disease: an essential review
title_full Impact of apolipoprotein E genetic polymorphisms on liver disease: an essential review
title_fullStr Impact of apolipoprotein E genetic polymorphisms on liver disease: an essential review
title_full_unstemmed Impact of apolipoprotein E genetic polymorphisms on liver disease: an essential review
title_sort Impact of apolipoprotein E genetic polymorphisms on liver disease: an essential review
author Nascimento, José Carlos Rodrigues
author_facet Nascimento, José Carlos Rodrigues
Matos, Gabriella A.
Pereira, Lianna C.
Mourão, Anderson E.C.C.B.
Sampaio, Aline M.
Oriá, Reinaldo B.
Toniuttoc, Pierluigi
author_role author
author2 Matos, Gabriella A.
Pereira, Lianna C.
Mourão, Anderson E.C.C.B.
Sampaio, Aline M.
Oriá, Reinaldo B.
Toniuttoc, Pierluigi
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nascimento, José Carlos Rodrigues
Matos, Gabriella A.
Pereira, Lianna C.
Mourão, Anderson E.C.C.B.
Sampaio, Aline M.
Oriá, Reinaldo B.
Toniuttoc, Pierluigi
dc.subject.por.fl_str_mv Apolipoproteínas E
Apolipoprotein E
Liver cirrhosis
Cirrose Hepática
Liver diseases
Hepatopatias
Liver transplantation
Transplante de Fígado
topic Apolipoproteínas E
Apolipoprotein E
Liver cirrhosis
Cirrose Hepática
Liver diseases
Hepatopatias
Liver transplantation
Transplante de Fígado
description Cirrhosis is an advanced stage of liver disease, compromising liver function with systemic health implications and poor quality of life. Hepatitis C virus (HCV) infection and alcoholic liver disease are the main causes of this pathology. However, since genetic factors may play a large role in the progression and severity of liver disease, and as apolipoprotein E (apoE) has been recognised to be mainly synthesised in the liver, apoE polymorphism studies are important to better understand the causal mechanisms in liver diseases. In this review, we summarise up-to-date studies addressing how apoE polymorphisms influence liver cirrhosis and liver transplantation outcomes and potential protective mechanisms. Although more clinical studies are needed to support these findings, the apoE 4 allele seems to be protective against the progression of liver cirrhosis in the majority of aetiologies and the postoperative serum apoE phenotype of the transplanted subject receptors was converted to that of the donor, indicating that >90% of apoE in plasma is synthesised in the hepatic system.
publishDate 2020
dc.date.none.fl_str_mv 2020-01
2021-04-20T18:44:37Z
2021-04-20T18:44:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv NASCIMENTO, J. C. R. et al. Impact of apolipoprotein E genetic polymorphisms on liver disease: An essential review. Annals of Hepatology, v. 19, n. 1, p. 24-30, 2020. Disponível em: https://www.sciencedirect.com/science/article/pii/S1665268119322185?via%3Dihub. Acesso em: 20 abr. 2021.
1665-2681
http://www.repositorio.ufc.br/handle/riufc/57881
dc.identifier.dark.fl_str_mv ark:/83112/00130000075xz
identifier_str_mv NASCIMENTO, J. C. R. et al. Impact of apolipoprotein E genetic polymorphisms on liver disease: An essential review. Annals of Hepatology, v. 19, n. 1, p. 24-30, 2020. Disponível em: https://www.sciencedirect.com/science/article/pii/S1665268119322185?via%3Dihub. Acesso em: 20 abr. 2021.
1665-2681
ark:/83112/00130000075xz
url http://www.repositorio.ufc.br/handle/riufc/57881
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Annals of Hepatology
publisher.none.fl_str_mv Annals of Hepatology
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
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