Impact of apolipoprotein E genetic polymorphisms on liver disease: an essential review
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
dARK ID: | ark:/83112/00130000075xz |
Texto Completo: | http://www.repositorio.ufc.br/handle/riufc/57881 |
Resumo: | Cirrhosis is an advanced stage of liver disease, compromising liver function with systemic health implications and poor quality of life. Hepatitis C virus (HCV) infection and alcoholic liver disease are the main causes of this pathology. However, since genetic factors may play a large role in the progression and severity of liver disease, and as apolipoprotein E (apoE) has been recognised to be mainly synthesised in the liver, apoE polymorphism studies are important to better understand the causal mechanisms in liver diseases. In this review, we summarise up-to-date studies addressing how apoE polymorphisms influence liver cirrhosis and liver transplantation outcomes and potential protective mechanisms. Although more clinical studies are needed to support these findings, the apoE 4 allele seems to be protective against the progression of liver cirrhosis in the majority of aetiologies and the postoperative serum apoE phenotype of the transplanted subject receptors was converted to that of the donor, indicating that >90% of apoE in plasma is synthesised in the hepatic system. |
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Repositório Institucional da Universidade Federal do Ceará (UFC) |
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Impact of apolipoprotein E genetic polymorphisms on liver disease: an essential reviewApolipoproteínas EApolipoprotein ELiver cirrhosisCirrose HepáticaLiver diseasesHepatopatiasLiver transplantationTransplante de FígadoCirrhosis is an advanced stage of liver disease, compromising liver function with systemic health implications and poor quality of life. Hepatitis C virus (HCV) infection and alcoholic liver disease are the main causes of this pathology. However, since genetic factors may play a large role in the progression and severity of liver disease, and as apolipoprotein E (apoE) has been recognised to be mainly synthesised in the liver, apoE polymorphism studies are important to better understand the causal mechanisms in liver diseases. In this review, we summarise up-to-date studies addressing how apoE polymorphisms influence liver cirrhosis and liver transplantation outcomes and potential protective mechanisms. Although more clinical studies are needed to support these findings, the apoE 4 allele seems to be protective against the progression of liver cirrhosis in the majority of aetiologies and the postoperative serum apoE phenotype of the transplanted subject receptors was converted to that of the donor, indicating that >90% of apoE in plasma is synthesised in the hepatic system.Annals of Hepatology2021-04-20T18:44:37Z2021-04-20T18:44:37Z2020-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfNASCIMENTO, J. C. R. et al. Impact of apolipoprotein E genetic polymorphisms on liver disease: An essential review. Annals of Hepatology, v. 19, n. 1, p. 24-30, 2020. Disponível em: https://www.sciencedirect.com/science/article/pii/S1665268119322185?via%3Dihub. Acesso em: 20 abr. 2021.1665-2681http://www.repositorio.ufc.br/handle/riufc/57881ark:/83112/00130000075xzNascimento, José Carlos RodriguesMatos, Gabriella A.Pereira, Lianna C.Mourão, Anderson E.C.C.B.Sampaio, Aline M.Oriá, Reinaldo B.Toniuttoc, Pierluigiengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2023-08-25T23:02:55Zoai:repositorio.ufc.br:riufc/57881Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:33:26.433844Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false |
dc.title.none.fl_str_mv |
Impact of apolipoprotein E genetic polymorphisms on liver disease: an essential review |
title |
Impact of apolipoprotein E genetic polymorphisms on liver disease: an essential review |
spellingShingle |
Impact of apolipoprotein E genetic polymorphisms on liver disease: an essential review Nascimento, José Carlos Rodrigues Apolipoproteínas E Apolipoprotein E Liver cirrhosis Cirrose Hepática Liver diseases Hepatopatias Liver transplantation Transplante de Fígado |
title_short |
Impact of apolipoprotein E genetic polymorphisms on liver disease: an essential review |
title_full |
Impact of apolipoprotein E genetic polymorphisms on liver disease: an essential review |
title_fullStr |
Impact of apolipoprotein E genetic polymorphisms on liver disease: an essential review |
title_full_unstemmed |
Impact of apolipoprotein E genetic polymorphisms on liver disease: an essential review |
title_sort |
Impact of apolipoprotein E genetic polymorphisms on liver disease: an essential review |
author |
Nascimento, José Carlos Rodrigues |
author_facet |
Nascimento, José Carlos Rodrigues Matos, Gabriella A. Pereira, Lianna C. Mourão, Anderson E.C.C.B. Sampaio, Aline M. Oriá, Reinaldo B. Toniuttoc, Pierluigi |
author_role |
author |
author2 |
Matos, Gabriella A. Pereira, Lianna C. Mourão, Anderson E.C.C.B. Sampaio, Aline M. Oriá, Reinaldo B. Toniuttoc, Pierluigi |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Nascimento, José Carlos Rodrigues Matos, Gabriella A. Pereira, Lianna C. Mourão, Anderson E.C.C.B. Sampaio, Aline M. Oriá, Reinaldo B. Toniuttoc, Pierluigi |
dc.subject.por.fl_str_mv |
Apolipoproteínas E Apolipoprotein E Liver cirrhosis Cirrose Hepática Liver diseases Hepatopatias Liver transplantation Transplante de Fígado |
topic |
Apolipoproteínas E Apolipoprotein E Liver cirrhosis Cirrose Hepática Liver diseases Hepatopatias Liver transplantation Transplante de Fígado |
description |
Cirrhosis is an advanced stage of liver disease, compromising liver function with systemic health implications and poor quality of life. Hepatitis C virus (HCV) infection and alcoholic liver disease are the main causes of this pathology. However, since genetic factors may play a large role in the progression and severity of liver disease, and as apolipoprotein E (apoE) has been recognised to be mainly synthesised in the liver, apoE polymorphism studies are important to better understand the causal mechanisms in liver diseases. In this review, we summarise up-to-date studies addressing how apoE polymorphisms influence liver cirrhosis and liver transplantation outcomes and potential protective mechanisms. Although more clinical studies are needed to support these findings, the apoE 4 allele seems to be protective against the progression of liver cirrhosis in the majority of aetiologies and the postoperative serum apoE phenotype of the transplanted subject receptors was converted to that of the donor, indicating that >90% of apoE in plasma is synthesised in the hepatic system. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01 2021-04-20T18:44:37Z 2021-04-20T18:44:37Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
NASCIMENTO, J. C. R. et al. Impact of apolipoprotein E genetic polymorphisms on liver disease: An essential review. Annals of Hepatology, v. 19, n. 1, p. 24-30, 2020. Disponível em: https://www.sciencedirect.com/science/article/pii/S1665268119322185?via%3Dihub. Acesso em: 20 abr. 2021. 1665-2681 http://www.repositorio.ufc.br/handle/riufc/57881 |
dc.identifier.dark.fl_str_mv |
ark:/83112/00130000075xz |
identifier_str_mv |
NASCIMENTO, J. C. R. et al. Impact of apolipoprotein E genetic polymorphisms on liver disease: An essential review. Annals of Hepatology, v. 19, n. 1, p. 24-30, 2020. Disponível em: https://www.sciencedirect.com/science/article/pii/S1665268119322185?via%3Dihub. Acesso em: 20 abr. 2021. 1665-2681 ark:/83112/00130000075xz |
url |
http://www.repositorio.ufc.br/handle/riufc/57881 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Annals of Hepatology |
publisher.none.fl_str_mv |
Annals of Hepatology |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da Universidade Federal do Ceará (UFC) instname:Universidade Federal do Ceará (UFC) instacron:UFC |
instname_str |
Universidade Federal do Ceará (UFC) |
instacron_str |
UFC |
institution |
UFC |
reponame_str |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
collection |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
repository.name.fl_str_mv |
Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC) |
repository.mail.fl_str_mv |
bu@ufc.br || repositorio@ufc.br |
_version_ |
1818373724372467712 |