Weight loss during cirrhosis is related to the etiology of liver disease
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFLA |
Texto Completo: | http://repositorio.ufla.br/jspui/handle/1/38770 |
Resumo: | CONTEXT: Malnutrition is widely described in patients waiting for liver transplantation (LTx). However, risk factors associated with weight loss during liver disease have not yet been well studied. OBJECTIVES: The aim of this study was to assess weight loss and its risk factors during liver disease and up to the first appointment after transplantation. Patients who underwent LTx were retrospectively assessed for weight loss during liver disease while on the waiting list for LTx. The usual weight of the patients before disease and their weight on the first outpatient appointment after transplant were considered. Demographic, socioeconomic, lifestyle and clinical variables were collected to assess risk factors using a linear regression analysis. We retrospectively evaluated 163 patients undergoing LTx between 1997 and 2008. RESULTS: Patients lost in average 7.7 ± 12.4 kg while ill. Variables independently associated with weight loss by multiple linear regression analyses were as follows: former smoker (P = 0.03), greater body mass index (P<0.01), overweight before liver disease (P = 0.02) and indication for LTx (P = 0.01). Among these indications, patients with alcoholic cirrhosis had lost significantly more weight (P<0.01), and those with hepatitis C virus (P = 0.01) and autoimmune hepatitis (P = 0.02) had lost significantly less weight. CONCLUSIONS: Patients experienced weight loss during liver disease independent of age, sex, schooling and income; however, the etiology of liver disease was related to weight loss. |
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Weight loss during cirrhosis is related to the etiology of liver diseasePerda de peso durante a cirrose está relacionada à causa da doença hepáticaWeight lossLiver cirrhosisAlcoholicLiver diseasesLiver transplantationPerda de pesoCirrose hepática alcoólicaHepatopatiasTransplante de fígadoCONTEXT: Malnutrition is widely described in patients waiting for liver transplantation (LTx). However, risk factors associated with weight loss during liver disease have not yet been well studied. OBJECTIVES: The aim of this study was to assess weight loss and its risk factors during liver disease and up to the first appointment after transplantation. Patients who underwent LTx were retrospectively assessed for weight loss during liver disease while on the waiting list for LTx. The usual weight of the patients before disease and their weight on the first outpatient appointment after transplant were considered. Demographic, socioeconomic, lifestyle and clinical variables were collected to assess risk factors using a linear regression analysis. We retrospectively evaluated 163 patients undergoing LTx between 1997 and 2008. RESULTS: Patients lost in average 7.7 ± 12.4 kg while ill. Variables independently associated with weight loss by multiple linear regression analyses were as follows: former smoker (P = 0.03), greater body mass index (P<0.01), overweight before liver disease (P = 0.02) and indication for LTx (P = 0.01). Among these indications, patients with alcoholic cirrhosis had lost significantly more weight (P<0.01), and those with hepatitis C virus (P = 0.01) and autoimmune hepatitis (P = 0.02) had lost significantly less weight. CONCLUSIONS: Patients experienced weight loss during liver disease independent of age, sex, schooling and income; however, the etiology of liver disease was related to weight loss.CONTEXTO: A desnutrição é amplamente descrita em pacientes à espera de transplante hepático (LTx). No entanto, fatores de risco associados à perda de peso durante a doença do fígado ainda não foram bem estudados. OBJETIVOS: Avaliar a perda de peso e seus fatores de risco durante a doença do fígado e até a primeira consulta após o transplante. Pacientes submetidos ao LTx foram retrospectivamente avaliados para perda de peso durante a doença do fígado, enquanto na lista de espera para LTx. O peso usual dos pacientes antes da doença e seu primeiro peso ambulatorial após o transplante foram considerados para as análises. Variáveis demográficas, de estilo de vida, socioeconômicas e variáveis clínicas foram coletadas para avaliar fatores de risco, usando análise de regressão linear múltipla. RESULTADOS: Foram avaliados retrospectivamente 163 pacientes submetidos a LTx entre 1997 e 2008. Os pacientes perderam em média 7,7 ± 12,4 kg, quando doentes. Variáveis independentemente associadas à perda de peso foram as seguintes: ex-fumante (P = 0,03), maior índice de massa corporal (P<0,01), excesso de peso antes de doença hepática (P = 0,02), indicação ao transplante (P = 0,01). Das indicações ao transplante, os indivíduos que foram diagnosticados com cirrose etanólica perderam significantemente mais peso (P<0,01) e os diagnosticados com hepatite viral C (P = 0,01) e hepatite autoimune (P = 0,02), significantemente menos. CONCLUSÕES: Os pacientes estudados apresentaram perda de peso durante a doença do fígado independentemente da idade, sexo, escolaridade e renda, no entanto, a causa da doença hepática esteve relacionada à perda de peso.Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades (IBEPEGE)2020-01-30T18:31:32Z2020-01-30T18:31:32Z2012info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfANASTÁCIO, L. R. et al. Weight loss during cirrhosis is related to the etiology of liver disease. Arquivos de Gastroenterologia, São Paulo, v. 49, n. 3, July/Sept. 2012.http://repositorio.ufla.br/jspui/handle/1/38770Arquivos de Gastroenterologiareponame:Repositório Institucional da UFLAinstname:Universidade Federal de Lavras (UFLA)instacron:UFLAAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessAnastácio, Lucilene RezendeFerreira, Lívia GarciaRibeiro, Hélem de SenaLima, Agnaldo SoaresVilela, Eduardo GarciaCorreia, Maria Isabel Toulson Davissoneng2020-01-30T18:31:32Zoai:localhost:1/38770Repositório InstitucionalPUBhttp://repositorio.ufla.br/oai/requestnivaldo@ufla.br || repositorio.biblioteca@ufla.bropendoar:2020-01-30T18:31:32Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA)false |
dc.title.none.fl_str_mv |
Weight loss during cirrhosis is related to the etiology of liver disease Perda de peso durante a cirrose está relacionada à causa da doença hepática |
title |
Weight loss during cirrhosis is related to the etiology of liver disease |
spellingShingle |
Weight loss during cirrhosis is related to the etiology of liver disease Anastácio, Lucilene Rezende Weight loss Liver cirrhosis Alcoholic Liver diseases Liver transplantation Perda de peso Cirrose hepática alcoólica Hepatopatias Transplante de fígado |
title_short |
Weight loss during cirrhosis is related to the etiology of liver disease |
title_full |
Weight loss during cirrhosis is related to the etiology of liver disease |
title_fullStr |
Weight loss during cirrhosis is related to the etiology of liver disease |
title_full_unstemmed |
Weight loss during cirrhosis is related to the etiology of liver disease |
title_sort |
Weight loss during cirrhosis is related to the etiology of liver disease |
author |
Anastácio, Lucilene Rezende |
author_facet |
Anastácio, Lucilene Rezende Ferreira, Lívia Garcia Ribeiro, Hélem de Sena Lima, Agnaldo Soares Vilela, Eduardo Garcia Correia, Maria Isabel Toulson Davisson |
author_role |
author |
author2 |
Ferreira, Lívia Garcia Ribeiro, Hélem de Sena Lima, Agnaldo Soares Vilela, Eduardo Garcia Correia, Maria Isabel Toulson Davisson |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Anastácio, Lucilene Rezende Ferreira, Lívia Garcia Ribeiro, Hélem de Sena Lima, Agnaldo Soares Vilela, Eduardo Garcia Correia, Maria Isabel Toulson Davisson |
dc.subject.por.fl_str_mv |
Weight loss Liver cirrhosis Alcoholic Liver diseases Liver transplantation Perda de peso Cirrose hepática alcoólica Hepatopatias Transplante de fígado |
topic |
Weight loss Liver cirrhosis Alcoholic Liver diseases Liver transplantation Perda de peso Cirrose hepática alcoólica Hepatopatias Transplante de fígado |
description |
CONTEXT: Malnutrition is widely described in patients waiting for liver transplantation (LTx). However, risk factors associated with weight loss during liver disease have not yet been well studied. OBJECTIVES: The aim of this study was to assess weight loss and its risk factors during liver disease and up to the first appointment after transplantation. Patients who underwent LTx were retrospectively assessed for weight loss during liver disease while on the waiting list for LTx. The usual weight of the patients before disease and their weight on the first outpatient appointment after transplant were considered. Demographic, socioeconomic, lifestyle and clinical variables were collected to assess risk factors using a linear regression analysis. We retrospectively evaluated 163 patients undergoing LTx between 1997 and 2008. RESULTS: Patients lost in average 7.7 ± 12.4 kg while ill. Variables independently associated with weight loss by multiple linear regression analyses were as follows: former smoker (P = 0.03), greater body mass index (P<0.01), overweight before liver disease (P = 0.02) and indication for LTx (P = 0.01). Among these indications, patients with alcoholic cirrhosis had lost significantly more weight (P<0.01), and those with hepatitis C virus (P = 0.01) and autoimmune hepatitis (P = 0.02) had lost significantly less weight. CONCLUSIONS: Patients experienced weight loss during liver disease independent of age, sex, schooling and income; however, the etiology of liver disease was related to weight loss. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012 2020-01-30T18:31:32Z 2020-01-30T18:31:32Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
ANASTÁCIO, L. R. et al. Weight loss during cirrhosis is related to the etiology of liver disease. Arquivos de Gastroenterologia, São Paulo, v. 49, n. 3, July/Sept. 2012. http://repositorio.ufla.br/jspui/handle/1/38770 |
identifier_str_mv |
ANASTÁCIO, L. R. et al. Weight loss during cirrhosis is related to the etiology of liver disease. Arquivos de Gastroenterologia, São Paulo, v. 49, n. 3, July/Sept. 2012. |
url |
http://repositorio.ufla.br/jspui/handle/1/38770 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades (IBEPEGE) |
publisher.none.fl_str_mv |
Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades (IBEPEGE) |
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Arquivos de Gastroenterologia reponame:Repositório Institucional da UFLA instname:Universidade Federal de Lavras (UFLA) instacron:UFLA |
instname_str |
Universidade Federal de Lavras (UFLA) |
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UFLA |
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UFLA |
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Repositório Institucional da UFLA |
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Repositório Institucional da UFLA |
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Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA) |
repository.mail.fl_str_mv |
nivaldo@ufla.br || repositorio.biblioteca@ufla.br |
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1815438958871445504 |