Evaluation of the anticonvulsant activity of Terpinen-4-ol

• Autor(a) principal: SOUSA, Damião Pergentino de.
• Data de Publicação: 2009
• Outros Autores: NÓBREGA, Franklin Ferreira de Farias., MORAIS, Liana Clébia Lima., ALMEIDA, Reinaldo Nobrega de.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Biblioteca Digital de Teses e Dissertações da UFCG
• Texto Completo: http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37243
• topic: Anticonvulsant activity; Terpinen-4-ol; Essential oils; Atividade anticonvulsivante; Óleos essenciais; Farmácia.; Química.

Terpinen-4-ol is a monoterpenoid alcohol and component of the essential oils of sever- al aromatic plants. Similarly to terpinen-4-ol, other monoterpenoid alcohols have shown anticonvulsant activity in convulsion animal models. The present study aimed to investigate the anticonvulsant activity of terpinen-4-ol. Treatment of mice with terpinen-4-ol ( 200 mg/kg) caused a signifi cant decrease in the spontaneous motor activity at 30, 60 and 120 min after administration. Terpinen-4-ol (100 and 200 mg/kg) produced a signifi cant dose- dependent increase in the duration of sleeping in mice. Pretreatment of mice with terpinen-4-ol at doses of 100, 200 and 300 mg/kg signifi cantly increased the latency of pentylenetetrazole-induced convulsions. Terpinen-4-ol (200 and 300 mg/kg) also inhibited the induced seizures of picrotoxin. In another model, maximal electroshock seizure, terpinen-4-ol decreased the tonic hind convulsions percentage at the dose of 300 mg/kg. From the overall results we can conclude that terpinen-4-ol showed a depressant effect on the central nervous system and signifi cant anticonvulsant activity.