Effectiveness of chitosan films impregnated with ciprofloxacin for the prophylaxis of osteomyelitis in open fractures: an experimental study in rats
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | http://hdl.handle.net/1843/53597 https://orcid.org/0000-0002-2034-0294 |
Resumo: | Background: The systemic antimicrobial prophylaxis is the standard treatment in the prevention of osteomyelitis after open fractures, with topical application of antimicrobials as an alternative due to their high concentrations at the site of the fracture, low systemic concentrations and fewer side effects. Objectives: This study aimed to evaluate the effectiveness of prophylaxis of osteomyelitis through experimental model of open fractures with the use of chitosan films, whether or not impregnated with ciprofloxacin. Materials and Methods: In this experimental study, 24 Holtzman rats were distributed into 4 groups of 6 rats each. The CT (control of treatment) group: an open fracture model treated with systemic antimicrobial; the IC (infection control) group: an open fracture untreated model; the C (chitosan) group: an open fracture model treated using a chitosan film; and the CA (chitosan with antimicrobial) group: an open fracture model treated using a chitosan film impregnated with antimicrobial. After 3 weeks the animals were killed by an overdose of anesthetic, and a fragment osseous was removed for histological and microbiological analysis. The comparisons between the groups considered significant values of P ≤ 0.05. Results: In cultures of the CT group, there was less bacterial growth compared to the results of the cultures of the IC (P = 0.005), C (P = 0.005) and CA (P = 0.009) groups. The inflammation was lower in the CT group compared to the IC (P = 0.014), C (P = 0.001) and CA (P = 0.007) groups. Conclusions: In this experimental model of open fracture, the chitosan film pure or impregnated with ciprofloxacin was not effec tive in the prophylaxis of osteomyelitis. |
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2023-05-18T19:58:57Z2023-05-18T19:58:57Z2016-05-10531610.5812/atr.369522251953Xhttp://hdl.handle.net/1843/53597https://orcid.org/0000-0002-2034-0294Background: The systemic antimicrobial prophylaxis is the standard treatment in the prevention of osteomyelitis after open fractures, with topical application of antimicrobials as an alternative due to their high concentrations at the site of the fracture, low systemic concentrations and fewer side effects. Objectives: This study aimed to evaluate the effectiveness of prophylaxis of osteomyelitis through experimental model of open fractures with the use of chitosan films, whether or not impregnated with ciprofloxacin. Materials and Methods: In this experimental study, 24 Holtzman rats were distributed into 4 groups of 6 rats each. The CT (control of treatment) group: an open fracture model treated with systemic antimicrobial; the IC (infection control) group: an open fracture untreated model; the C (chitosan) group: an open fracture model treated using a chitosan film; and the CA (chitosan with antimicrobial) group: an open fracture model treated using a chitosan film impregnated with antimicrobial. After 3 weeks the animals were killed by an overdose of anesthetic, and a fragment osseous was removed for histological and microbiological analysis. The comparisons between the groups considered significant values of P ≤ 0.05. Results: In cultures of the CT group, there was less bacterial growth compared to the results of the cultures of the IC (P = 0.005), C (P = 0.005) and CA (P = 0.009) groups. The inflammation was lower in the CT group compared to the IC (P = 0.014), C (P = 0.001) and CA (P = 0.007) groups. Conclusions: In this experimental model of open fracture, the chitosan film pure or impregnated with ciprofloxacin was not effec tive in the prophylaxis of osteomyelitis.engUniversidade Federal de Minas GeraisUFMGBrasilFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSMED - DEPARTAMENTO DE ANATOMIA PATOLÓGICA E MEDICINA LEGALMED - DEPARTAMENTO DE APARELHO LOCOMOTORMED - DEPARTAMENTO DE CIRURGIAArchives of Trauma ResearchFraturas ExpostasOsteomieliteCiprofloxacinaQuitosanaOpen FractureProphylaxisOsteomyelitisChitosanCiprofloxacinEffectiveness of chitosan films impregnated with ciprofloxacin for the prophylaxis of osteomyelitis in open fractures: an experimental study in ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://archtrauma.kaums.ac.ir/journal/aboutLincolnpaiva CostaLuiz Eduardo Moreira TeixeiraGustavo Silame Maranhão LimaMarcelo Mendes FerreiraMateus Antunes de AndradePaula Vieira Teixeira VidigalAndré Augusto Gomes FaracoEduardo Frois TemponiIvana Duval de Araújoapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/53597/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALEffectiveness of Chitosan Films Impregnated wirh Ciprofloxacin for the the Prophylaxis of Osteomyelitis in Open Fractures pdfa.pdfEffectiveness of Chitosan Films Impregnated wirh Ciprofloxacin for the the Prophylaxis of Osteomyelitis in Open Fractures pdfa.pdfapplication/pdf156945https://repositorio.ufmg.br/bitstream/1843/53597/2/Effectiveness%20of%20Chitosan%20Films%20Impregnated%20wirh%20Ciprofloxacin%20for%20the%20the%20Prophylaxis%20of%20Osteomyelitis%20in%20Open%20Fractures%20pdfa.pdf949323de3fef967ca514a011037f264dMD521843/535972023-05-18 17:10:33.608oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-05-18T20:10:33Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Effectiveness of chitosan films impregnated with ciprofloxacin for the prophylaxis of osteomyelitis in open fractures: an experimental study in rats |
title |
Effectiveness of chitosan films impregnated with ciprofloxacin for the prophylaxis of osteomyelitis in open fractures: an experimental study in rats |
spellingShingle |
Effectiveness of chitosan films impregnated with ciprofloxacin for the prophylaxis of osteomyelitis in open fractures: an experimental study in rats Lincolnpaiva Costa Open Fracture Prophylaxis Osteomyelitis Chitosan Ciprofloxacin Fraturas Expostas Osteomielite Ciprofloxacina Quitosana |
title_short |
Effectiveness of chitosan films impregnated with ciprofloxacin for the prophylaxis of osteomyelitis in open fractures: an experimental study in rats |
title_full |
Effectiveness of chitosan films impregnated with ciprofloxacin for the prophylaxis of osteomyelitis in open fractures: an experimental study in rats |
title_fullStr |
Effectiveness of chitosan films impregnated with ciprofloxacin for the prophylaxis of osteomyelitis in open fractures: an experimental study in rats |
title_full_unstemmed |
Effectiveness of chitosan films impregnated with ciprofloxacin for the prophylaxis of osteomyelitis in open fractures: an experimental study in rats |
title_sort |
Effectiveness of chitosan films impregnated with ciprofloxacin for the prophylaxis of osteomyelitis in open fractures: an experimental study in rats |
author |
Lincolnpaiva Costa |
author_facet |
Lincolnpaiva Costa Luiz Eduardo Moreira Teixeira Gustavo Silame Maranhão Lima Marcelo Mendes Ferreira Mateus Antunes de Andrade Paula Vieira Teixeira Vidigal André Augusto Gomes Faraco Eduardo Frois Temponi Ivana Duval de Araújo |
author_role |
author |
author2 |
Luiz Eduardo Moreira Teixeira Gustavo Silame Maranhão Lima Marcelo Mendes Ferreira Mateus Antunes de Andrade Paula Vieira Teixeira Vidigal André Augusto Gomes Faraco Eduardo Frois Temponi Ivana Duval de Araújo |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Lincolnpaiva Costa Luiz Eduardo Moreira Teixeira Gustavo Silame Maranhão Lima Marcelo Mendes Ferreira Mateus Antunes de Andrade Paula Vieira Teixeira Vidigal André Augusto Gomes Faraco Eduardo Frois Temponi Ivana Duval de Araújo |
dc.subject.por.fl_str_mv |
Open Fracture Prophylaxis Osteomyelitis Chitosan Ciprofloxacin |
topic |
Open Fracture Prophylaxis Osteomyelitis Chitosan Ciprofloxacin Fraturas Expostas Osteomielite Ciprofloxacina Quitosana |
dc.subject.other.pt_BR.fl_str_mv |
Fraturas Expostas Osteomielite Ciprofloxacina Quitosana |
description |
Background: The systemic antimicrobial prophylaxis is the standard treatment in the prevention of osteomyelitis after open fractures, with topical application of antimicrobials as an alternative due to their high concentrations at the site of the fracture, low systemic concentrations and fewer side effects. Objectives: This study aimed to evaluate the effectiveness of prophylaxis of osteomyelitis through experimental model of open fractures with the use of chitosan films, whether or not impregnated with ciprofloxacin. Materials and Methods: In this experimental study, 24 Holtzman rats were distributed into 4 groups of 6 rats each. The CT (control of treatment) group: an open fracture model treated with systemic antimicrobial; the IC (infection control) group: an open fracture untreated model; the C (chitosan) group: an open fracture model treated using a chitosan film; and the CA (chitosan with antimicrobial) group: an open fracture model treated using a chitosan film impregnated with antimicrobial. After 3 weeks the animals were killed by an overdose of anesthetic, and a fragment osseous was removed for histological and microbiological analysis. The comparisons between the groups considered significant values of P ≤ 0.05. Results: In cultures of the CT group, there was less bacterial growth compared to the results of the cultures of the IC (P = 0.005), C (P = 0.005) and CA (P = 0.009) groups. The inflammation was lower in the CT group compared to the IC (P = 0.014), C (P = 0.001) and CA (P = 0.007) groups. Conclusions: In this experimental model of open fracture, the chitosan film pure or impregnated with ciprofloxacin was not effec tive in the prophylaxis of osteomyelitis. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016-05-10 |
dc.date.accessioned.fl_str_mv |
2023-05-18T19:58:57Z |
dc.date.available.fl_str_mv |
2023-05-18T19:58:57Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/53597 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.5812/atr.36952 |
dc.identifier.issn.pt_BR.fl_str_mv |
2251953X |
dc.identifier.orcid.pt_BR.fl_str_mv |
https://orcid.org/0000-0002-2034-0294 |
identifier_str_mv |
10.5812/atr.36952 2251953X |
url |
http://hdl.handle.net/1843/53597 https://orcid.org/0000-0002-2034-0294 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Archives of Trauma Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
FAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS MED - DEPARTAMENTO DE ANATOMIA PATOLÓGICA E MEDICINA LEGAL MED - DEPARTAMENTO DE APARELHO LOCOMOTOR MED - DEPARTAMENTO DE CIRURGIA |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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Universidade Federal de Minas Gerais (UFMG) |
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UFMG |
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UFMG |
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Repositório Institucional da UFMG |
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Repositório Institucional da UFMG |
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