Versican and tumor-associated macrophages promotes tumor progression and metastasis in canine and murine models of breast carcinoma
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.3389/fonc.2019.00577 http://hdl.handle.net/1843/56435 https://orcid.org/0000-0002-9676-7745 https://orcid.org/0000-0003-2087-1690 https://orcid.org/0000-0003-4696-7738 https://orcid.org/0000-0003-2285-8334 https://orcid.org/0000-0002-0233-7729 https://orcid.org/0000-0002-9163-6279 https://orcid.org/0000-0001-7714-991X https://orcid.org/0000-0002-1835-0303 https://orcid.org/0000-0002-1715-3834 https://orcid.org/0000-0002-5650-6743 |
Resumo: | Versican and tumor-associated macrophages (TAMs) are involved in growth and metastases in several cancers. Here, we investigated the potential role of versican, a matrix proteoglycan, and its correlation with TAMs infiltrates in different stages of two different breast cancer models: spontaneous canine mammary gland carcinomas and the murine 4T1 breast cancer model. The stromal versican expression was correlated with TAMs accumulation in tumors with an advanced stage from spontaneous canine mammary carcinoma samples. Versican expression in mice, identified in late stages of tumor progression, was associated to a high number of peri-tumoral infiltrating TAMs. Indeed, TAMs were related to a pro-inflammatory and pro-angiogenic state in the primary tumor. Furthermore, TAMs accumulation was related to versican expression in the lungs and an increased number of pulmonary metastatic nodules with pulmonary mechanical dysfunction, which was due to leukocyte influx in the airways and elevated growth factor levels in the microenvironment. Thus, we suggest that versican and TAMs as attractive targets for breast cancer therapy. |
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2023-07-17T18:49:52Z2023-07-17T18:49:52Z20199https://doi.org/10.3389/fonc.2019.005772234-943Xhttp://hdl.handle.net/1843/56435https://orcid.org/0000-0002-9676-7745https://orcid.org/0000-0003-2087-1690https://orcid.org/0000-0003-4696-7738https://orcid.org/0000-0003-2285-8334https://orcid.org/0000-0002-0233-7729https://orcid.org/0000-0002-9163-6279https://orcid.org/0000-0001-7714-991Xhttps://orcid.org/0000-0002-1835-0303https://orcid.org/0000-0002-1715-3834https://orcid.org/0000-0002-5650-6743Versican and tumor-associated macrophages (TAMs) are involved in growth and metastases in several cancers. Here, we investigated the potential role of versican, a matrix proteoglycan, and its correlation with TAMs infiltrates in different stages of two different breast cancer models: spontaneous canine mammary gland carcinomas and the murine 4T1 breast cancer model. The stromal versican expression was correlated with TAMs accumulation in tumors with an advanced stage from spontaneous canine mammary carcinoma samples. Versican expression in mice, identified in late stages of tumor progression, was associated to a high number of peri-tumoral infiltrating TAMs. Indeed, TAMs were related to a pro-inflammatory and pro-angiogenic state in the primary tumor. Furthermore, TAMs accumulation was related to versican expression in the lungs and an increased number of pulmonary metastatic nodules with pulmonary mechanical dysfunction, which was due to leukocyte influx in the airways and elevated growth factor levels in the microenvironment. Thus, we suggest that versican and TAMs as attractive targets for breast cancer therapy.Versican e macrófagos associados a tumores (TAMs) estão envolvidos no crescimento e metástases em vários tipos de câncer. Aqui, investigamos o papel potencial do versican, um proteoglicano de matriz, e sua correlação com infiltrados de TAMs em diferentes estágios de dois modelos diferentes de câncer de mama: carcinomas espontâneos da glândula mamária canina e modelo de câncer de mama murino 4T1. A expressão estromal de versican foi correlacionada com o acúmulo de TAMs em tumores com estágio avançado de amostras espontâneas de carcinoma mamário canino. A expressão de versican em camundongos, identificada em estágios tardios de progressão tumoral, foi associada a um alto número de TAMs infiltrantes peritumorais. De fato, os TAMs foram relacionados a um estado pró-inflamatório e pró-angiogênico no tumor primário. Além disso, o acúmulo de TAMs foi relacionado à expressão de versican nos pulmões e a um aumento do número de nódulos metastáticos pulmonares com disfunção mecânica pulmonar, devido ao influxo de leucócitos nas vias aéreas e níveis elevados de fator de crescimento no microambiente. Assim, sugerimos que o versican e os TAMs são alvos atraentes para a terapia do câncer de mama.CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorengUniversidade Federal de Minas GeraisUFMGBrasilICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIAICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICAICB - DEPARTAMENTO DE PATOLOGIAFrontiers in OncologyNeoplasias da mamaNeovascularizaçãoMetástase neoplásica-pulmãoVersicanasMacrófagos associados a tumorBreast cancerAngiogenesisLung metastasisVersicanTumor-associated macrophagesVersican and tumor-associated macrophages promotes tumor progression and metastasis in canine and murine models of breast carcinomaMacrófagos versicanos e associados a tumores promovem progressão tumoral e metástase em modelos caninos e murinos de carcinoma de mamainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2019.00577/fullDiego Carlos Dos ReisKarine Araújo DamascenoCecília Bonolo de CamposEmerson Soares VelosoGabriela Rafaela Arantes PêgasLucas Rocha KraemerMichele Angela RodriguesMatheus Silvério MattosDawidson Assis GomesPaula Peixoto CamposEnio FerreiraRemo Castro RussoGeovanni Dantas Cassaliapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/56435/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALVersican and tumor-associated macrophages promotes tumor progression and metastasis in canine and murine models of breast carcinoma.pdfVersican and tumor-associated macrophages promotes tumor progression and metastasis in canine and murine models of breast carcinoma.pdfapplication/pdf264025577https://repositorio.ufmg.br/bitstream/1843/56435/2/Versican%20and%20tumor-associated%20macrophages%20promotes%20tumor%20progression%20and%20metastasis%20in%20canine%20and%20murine%20models%20of%20breast%20carcinoma.pdfc857c86c39a772410a5c9df32d4bcc4eMD521843/564352023-07-17 15:49:52.755oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-07-17T18:49:52Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Versican and tumor-associated macrophages promotes tumor progression and metastasis in canine and murine models of breast carcinoma |
dc.title.alternative.pt_BR.fl_str_mv |
Macrófagos versicanos e associados a tumores promovem progressão tumoral e metástase em modelos caninos e murinos de carcinoma de mama |
title |
Versican and tumor-associated macrophages promotes tumor progression and metastasis in canine and murine models of breast carcinoma |
spellingShingle |
Versican and tumor-associated macrophages promotes tumor progression and metastasis in canine and murine models of breast carcinoma Diego Carlos Dos Reis Breast cancer Angiogenesis Lung metastasis Versican Tumor-associated macrophages Neoplasias da mama Neovascularização Metástase neoplásica-pulmão Versicanas Macrófagos associados a tumor |
title_short |
Versican and tumor-associated macrophages promotes tumor progression and metastasis in canine and murine models of breast carcinoma |
title_full |
Versican and tumor-associated macrophages promotes tumor progression and metastasis in canine and murine models of breast carcinoma |
title_fullStr |
Versican and tumor-associated macrophages promotes tumor progression and metastasis in canine and murine models of breast carcinoma |
title_full_unstemmed |
Versican and tumor-associated macrophages promotes tumor progression and metastasis in canine and murine models of breast carcinoma |
title_sort |
Versican and tumor-associated macrophages promotes tumor progression and metastasis in canine and murine models of breast carcinoma |
author |
Diego Carlos Dos Reis |
author_facet |
Diego Carlos Dos Reis Karine Araújo Damasceno Cecília Bonolo de Campos Emerson Soares Veloso Gabriela Rafaela Arantes Pêgas Lucas Rocha Kraemer Michele Angela Rodrigues Matheus Silvério Mattos Dawidson Assis Gomes Paula Peixoto Campos Enio Ferreira Remo Castro Russo Geovanni Dantas Cassali |
author_role |
author |
author2 |
Karine Araújo Damasceno Cecília Bonolo de Campos Emerson Soares Veloso Gabriela Rafaela Arantes Pêgas Lucas Rocha Kraemer Michele Angela Rodrigues Matheus Silvério Mattos Dawidson Assis Gomes Paula Peixoto Campos Enio Ferreira Remo Castro Russo Geovanni Dantas Cassali |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Diego Carlos Dos Reis Karine Araújo Damasceno Cecília Bonolo de Campos Emerson Soares Veloso Gabriela Rafaela Arantes Pêgas Lucas Rocha Kraemer Michele Angela Rodrigues Matheus Silvério Mattos Dawidson Assis Gomes Paula Peixoto Campos Enio Ferreira Remo Castro Russo Geovanni Dantas Cassali |
dc.subject.por.fl_str_mv |
Breast cancer Angiogenesis Lung metastasis Versican Tumor-associated macrophages |
topic |
Breast cancer Angiogenesis Lung metastasis Versican Tumor-associated macrophages Neoplasias da mama Neovascularização Metástase neoplásica-pulmão Versicanas Macrófagos associados a tumor |
dc.subject.other.pt_BR.fl_str_mv |
Neoplasias da mama Neovascularização Metástase neoplásica-pulmão Versicanas Macrófagos associados a tumor |
description |
Versican and tumor-associated macrophages (TAMs) are involved in growth and metastases in several cancers. Here, we investigated the potential role of versican, a matrix proteoglycan, and its correlation with TAMs infiltrates in different stages of two different breast cancer models: spontaneous canine mammary gland carcinomas and the murine 4T1 breast cancer model. The stromal versican expression was correlated with TAMs accumulation in tumors with an advanced stage from spontaneous canine mammary carcinoma samples. Versican expression in mice, identified in late stages of tumor progression, was associated to a high number of peri-tumoral infiltrating TAMs. Indeed, TAMs were related to a pro-inflammatory and pro-angiogenic state in the primary tumor. Furthermore, TAMs accumulation was related to versican expression in the lungs and an increased number of pulmonary metastatic nodules with pulmonary mechanical dysfunction, which was due to leukocyte influx in the airways and elevated growth factor levels in the microenvironment. Thus, we suggest that versican and TAMs as attractive targets for breast cancer therapy. |
publishDate |
2019 |
dc.date.issued.fl_str_mv |
2019 |
dc.date.accessioned.fl_str_mv |
2023-07-17T18:49:52Z |
dc.date.available.fl_str_mv |
2023-07-17T18:49:52Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/56435 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.3389/fonc.2019.00577 |
dc.identifier.issn.pt_BR.fl_str_mv |
2234-943X |
dc.identifier.orcid.pt_BR.fl_str_mv |
https://orcid.org/0000-0002-9676-7745 https://orcid.org/0000-0003-2087-1690 https://orcid.org/0000-0003-4696-7738 https://orcid.org/0000-0003-2285-8334 https://orcid.org/0000-0002-0233-7729 https://orcid.org/0000-0002-9163-6279 https://orcid.org/0000-0001-7714-991X https://orcid.org/0000-0002-1835-0303 https://orcid.org/0000-0002-1715-3834 https://orcid.org/0000-0002-5650-6743 |
url |
https://doi.org/10.3389/fonc.2019.00577 http://hdl.handle.net/1843/56435 https://orcid.org/0000-0002-9676-7745 https://orcid.org/0000-0003-2087-1690 https://orcid.org/0000-0003-4696-7738 https://orcid.org/0000-0003-2285-8334 https://orcid.org/0000-0002-0233-7729 https://orcid.org/0000-0002-9163-6279 https://orcid.org/0000-0001-7714-991X https://orcid.org/0000-0002-1835-0303 https://orcid.org/0000-0002-1715-3834 https://orcid.org/0000-0002-5650-6743 |
identifier_str_mv |
2234-943X |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Frontiers in Oncology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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ICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA ICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA ICB - DEPARTAMENTO DE PATOLOGIA |
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Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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