High-Salt Diet Induces IL-17-Dependent Gut Inflammation and Exacerbates Colitis in Mice
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | https://doi.org/10.3389/fimmu.2017.01969 http://hdl.handle.net/1843/66191 https://orcid.org/0000-0002-7538-3208 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2024-03-20T20:09:40Z2024-03-20T20:09:40Z2018-01-148196912https://doi.org/10.3389/fimmu.2017.019691664-3224http://hdl.handle.net/1843/66191https://orcid.org/0000-0002-7538-3208CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorExcess intake of sodium is often associated with high risk for cardiovascular disease. More recently, some studies on the effects of high-salt diets (HSDs) have also demonstrated that they are able to activate Th17 cells and increase severity of autoimmune diseases. The purpose of the present study was to evaluate the effects of a diet supplemented with NaCl in the colonic mucosa at steady state and during inflammation. We showed that consumption of HSD by mice triggered a gut inflammatory reaction associated with IL-23 production, recruitment of neutrophils, and increased frequency of the IL-17-producing type 3 innate lymphoid cells (ILC3) in the colon. Moreover, gut inflammation was not observed in IL-17–/– mice but it was present, although at lower grade, in RAG−/− mice suggesting that the inflammatory effects of HSD was dependent on IL-17 but only partially on Th17 cells. Expression of SGK1, a kinase involved in sodium homeostasis, increased 90 min after ingestion of 50% NaCl solution and decreased 3 weeks after HSD consumption. Colitis induced by oral administration of either dextran sodium sulfate or 2,4,6-trinitrobenzenesulfonic acid was exacerbated by HSD consumption and this effect was associated with increased frequencies of RORγt+ CD4+ T cells and neutrophils in the colon. Therefore, our results demonstrated that consumption of HSD per se triggered a histologically detectable inflammation in the colon and also exacerbated chemically induced models of colitis in mice by a mechanism dependent on IL-17 production most likely by both ILC3 and Th17 cells.engUniversidade Federal de Minas GeraisUFMGBrasilENF - DEPARTAMENTO DE NUTRIÇÃOENFERMAGEM - ESCOLA DE ENFERMAGEMFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIAICB - DEPARTAMENTO DE MORFOLOGIAFrontiers in ImmunologyCélulas Th17InflamaçãoInterleucina-17Cloreto de SódioSodium chlorideGut inflammationIL-17Th17 cellsILC3High-Salt Diet Induces IL-17-Dependent Gut Inflammation and Exacerbates Colitis in Miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.01969/fullSarah Leao Fiorini de AguiarValbert Nascimento CardosoPatrícia Aparecida BarrosTatiani Uceli MaioliAna Maria Caetano FariaMariana Camila Gonçalves MirandaMauro Andrade Freitas GuimarãesHelton Costa SantiagoCamila Pereira QueirozPricila da Silva CunhaDenise Carmona CaraGiselle FoureauxAnderson José Ferreiraapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/66191/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALHigh-Salt Diet Induces IL-17-Dependent Gut Inflammation and Exacerbates Colitis in Mice.pdfHigh-Salt Diet Induces IL-17-Dependent Gut Inflammation and Exacerbates Colitis in Mice.pdfapplication/pdf1713149https://repositorio.ufmg.br/bitstream/1843/66191/2/High-Salt%20Diet%20Induces%20IL-17-Dependent%20Gut%20Inflammation%20and%20Exacerbates%20Colitis%20in%20Mice.pdf3c68b7563a303ea60497db320af77b21MD521843/661912024-03-20 17:09:40.921oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2024-03-20T20:09:40Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
High-Salt Diet Induces IL-17-Dependent Gut Inflammation and Exacerbates Colitis in Mice |
| title |
High-Salt Diet Induces IL-17-Dependent Gut Inflammation and Exacerbates Colitis in Mice |
| spellingShingle |
High-Salt Diet Induces IL-17-Dependent Gut Inflammation and Exacerbates Colitis in Mice Sarah Leao Fiorini de Aguiar Sodium chloride Gut inflammation IL-17 Th17 cells ILC3 Células Th17 Inflamação Interleucina-17 Cloreto de Sódio |
| title_short |
High-Salt Diet Induces IL-17-Dependent Gut Inflammation and Exacerbates Colitis in Mice |
| title_full |
High-Salt Diet Induces IL-17-Dependent Gut Inflammation and Exacerbates Colitis in Mice |
| title_fullStr |
High-Salt Diet Induces IL-17-Dependent Gut Inflammation and Exacerbates Colitis in Mice |
| title_full_unstemmed |
High-Salt Diet Induces IL-17-Dependent Gut Inflammation and Exacerbates Colitis in Mice |
| title_sort |
High-Salt Diet Induces IL-17-Dependent Gut Inflammation and Exacerbates Colitis in Mice |
| author |
Sarah Leao Fiorini de Aguiar |
| author_facet |
Sarah Leao Fiorini de Aguiar Valbert Nascimento Cardoso Patrícia Aparecida Barros Tatiani Uceli Maioli Ana Maria Caetano Faria Mariana Camila Gonçalves Miranda Mauro Andrade Freitas Guimarães Helton Costa Santiago Camila Pereira Queiroz Pricila da Silva Cunha Denise Carmona Cara Giselle Foureaux Anderson José Ferreira |
| author_role |
author |
| author2 |
Valbert Nascimento Cardoso Patrícia Aparecida Barros Tatiani Uceli Maioli Ana Maria Caetano Faria Mariana Camila Gonçalves Miranda Mauro Andrade Freitas Guimarães Helton Costa Santiago Camila Pereira Queiroz Pricila da Silva Cunha Denise Carmona Cara Giselle Foureaux Anderson José Ferreira |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Sarah Leao Fiorini de Aguiar Valbert Nascimento Cardoso Patrícia Aparecida Barros Tatiani Uceli Maioli Ana Maria Caetano Faria Mariana Camila Gonçalves Miranda Mauro Andrade Freitas Guimarães Helton Costa Santiago Camila Pereira Queiroz Pricila da Silva Cunha Denise Carmona Cara Giselle Foureaux Anderson José Ferreira |
| dc.subject.por.fl_str_mv |
Sodium chloride Gut inflammation IL-17 Th17 cells ILC3 |
| topic |
Sodium chloride Gut inflammation IL-17 Th17 cells ILC3 Células Th17 Inflamação Interleucina-17 Cloreto de Sódio |
| dc.subject.other.pt_BR.fl_str_mv |
Células Th17 Inflamação Interleucina-17 Cloreto de Sódio |
| description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| publishDate |
2018 |
| dc.date.issued.fl_str_mv |
2018-01-14 |
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2024-03-20T20:09:40Z |
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2024-03-20T20:09:40Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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http://hdl.handle.net/1843/66191 |
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https://doi.org/10.3389/fimmu.2017.01969 |
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1664-3224 |
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https://orcid.org/0000-0002-7538-3208 |
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https://doi.org/10.3389/fimmu.2017.01969 http://hdl.handle.net/1843/66191 https://orcid.org/0000-0002-7538-3208 |
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1664-3224 |
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eng |
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eng |
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Frontiers in Immunology |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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ENF - DEPARTAMENTO DE NUTRIÇÃO ENFERMAGEM - ESCOLA DE ENFERMAGEM FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS ICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA ICB - DEPARTAMENTO DE MORFOLOGIA |
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Universidade Federal de Minas Gerais |
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