NANOEMULSÕES CONTENDO ÓLEO ESSENCIAL DE LAVANDULA DENTATA: DESENVOLVIMENTO E AVALIAÇÃO DA IRRITAÇÃO CUTÂNEA E DA EFICÁCIA NO TRATAMENTO DA INSÔNIA

Detalhes bibliográficos
Autor(a) principal: Barin, Ruth
Data de Publicação: 2023
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Institucional Universidade Franciscana
Texto Completo: http://www.tede.universidadefranciscana.edu.br:8080/handle/UFN-BDTD/1174
Resumo: Poor sleep quality can cause several changes and symptoms such as anxiety, reduced cognitive capacity and fatigue, changes that are aggravated during the period of the Covid-19 pandemic. In a non-drug approach, because it is more accessible and has fewer adverse effects, the use of essential oils is popularized as a treatment for various disorders, including insomnia. Lavender essential oil, one of the most commercialized worldwide, is widely used for its calming and sedative therapeutic properties. However, Lavandula dentata still has scarce studies to evaluate its sedative effect when compared to other species. Essential oils also have some limitations, such as low solubility in water and photosensitivity, which can be overcome when combined with nanotechnology. In this context, the objective of this study was to develop nanoemulsions containing essential oil of L. dentata, to evaluate the skin irritation in vitro, and its therapeutic effect in vivo through a clinical trial with the aim of treating self-reported insomnia in adults, with topical application. (massage) and inhalation (aromatherapy) of the oil in its free and nanemulsified form. The nanoemulsion was developed by high agitation method, and presented in its characterization an average diameter varying between 72 – 80 nm, PDI lower than 0.3, zeta potential -6,2mV and acidic pH. For its application in massage and aromatherapy, dilutions were made within the safe concentration range for use, in sweet almond carrier oil. Morphological analysis showed that the nanoemulsion droplets were present and without signs of degradation, when diluted in carrier oil, after 30 days. As a way of evaluating the irritant potential, the pure and diluted formulations in the carrier were evaluated in the HET-CAM method, which proved to be safe when in essential oil concentrations below 5%. Finally, after the clinical trial, the participants who received the essential oil of L. dentata had a significant difference in the improvement of sleep quality compared to those who received the nanoemulsion and placebo intervention (p=0.011). The results obtained from this intervention suggest that more adequate tests are needed to evaluate the release of active compounds from the developed nanoemulsion, when also diluted in carrier oil for topical application. However, the sedative effect of L. dentata, applied in combination via inhalation and topically, stands out as a potential treatment for poor sleep quality.
id UFN-1_0021107dfd83a570b0ccf51252fc882f
oai_identifier_str oai:tede.universidadefranciscana.edu.br:UFN-BDTD/1174
network_acronym_str UFN-1
network_name_str Repositório Institucional Universidade Franciscana
repository_id_str
spelling Ourique , Aline FerreiraNedel, Sheila SpohrSilva, Wiliam Leonardo daContri , Renata VidorBarin, Ruth2023-05-31T18:14:36Z2024-05-232023-02-27Barin, Ruth. NANOEMULSÕES CONTENDO ÓLEO ESSENCIAL DE LAVANDULA DENTATA: DESENVOLVIMENTO E AVALIAÇÃO DA IRRITAÇÃO CUTÂNEA E DA EFICÁCIA NO TRATAMENTO DA INSÔNIA. 2023. 78f. Dissertação( Programa de Pós-Graduação em Nanociências) - Universidade Franciscana, Santa Maria - RS.http://www.tede.universidadefranciscana.edu.br:8080/handle/UFN-BDTD/1174Poor sleep quality can cause several changes and symptoms such as anxiety, reduced cognitive capacity and fatigue, changes that are aggravated during the period of the Covid-19 pandemic. In a non-drug approach, because it is more accessible and has fewer adverse effects, the use of essential oils is popularized as a treatment for various disorders, including insomnia. Lavender essential oil, one of the most commercialized worldwide, is widely used for its calming and sedative therapeutic properties. However, Lavandula dentata still has scarce studies to evaluate its sedative effect when compared to other species. Essential oils also have some limitations, such as low solubility in water and photosensitivity, which can be overcome when combined with nanotechnology. In this context, the objective of this study was to develop nanoemulsions containing essential oil of L. dentata, to evaluate the skin irritation in vitro, and its therapeutic effect in vivo through a clinical trial with the aim of treating self-reported insomnia in adults, with topical application. (massage) and inhalation (aromatherapy) of the oil in its free and nanemulsified form. The nanoemulsion was developed by high agitation method, and presented in its characterization an average diameter varying between 72 – 80 nm, PDI lower than 0.3, zeta potential -6,2mV and acidic pH. For its application in massage and aromatherapy, dilutions were made within the safe concentration range for use, in sweet almond carrier oil. Morphological analysis showed that the nanoemulsion droplets were present and without signs of degradation, when diluted in carrier oil, after 30 days. As a way of evaluating the irritant potential, the pure and diluted formulations in the carrier were evaluated in the HET-CAM method, which proved to be safe when in essential oil concentrations below 5%. Finally, after the clinical trial, the participants who received the essential oil of L. dentata had a significant difference in the improvement of sleep quality compared to those who received the nanoemulsion and placebo intervention (p=0.011). The results obtained from this intervention suggest that more adequate tests are needed to evaluate the release of active compounds from the developed nanoemulsion, when also diluted in carrier oil for topical application. However, the sedative effect of L. dentata, applied in combination via inhalation and topically, stands out as a potential treatment for poor sleep quality.A má qualidade do sono pode causar diversas alterações e sintomas como ansiedade, redução da capacidade cognitiva e fadiga, as quais foram agravadas quando no período de pandemia da Covid-19. Em uma abordagem não medicamentosa, por ser mais acessível e apresentar menos efeitos adversos, populariza-se o uso de óleos essenciais como tratamento de diversos distúrbios como a insônia. O óleo essencial de lavanda, um dos mais comercializados mundialmente, é muito utilizado por suas propriedades terapêuticas calmantes e sedativas. Entretanto, a Lavandula dentata ainda tem estudos escassos para avaliar seu efeito sedativo quando comparado às outras espécies. Os óleos essenciais possuem também algumas limitações, como baixa solubilidade em água e fotossensibilidade, o que pode ser superado quando aliado à nanotecnologia. Neste contexto, o objetivo deste estudo foi desenvolver nanoemulsões contendo óleo essencial de L. dentata, avaliar a irritação cutânea in vitro, e seu efeito terapêutico in vivo por meio de um ensaio clínico com intuito de tratamento da insônia autorrelatada em adultos, com aplicação via tópica (massagem) e inalatória (aromaterapia) do óleo em sua forma livre e nanoemulsionada. A nanoemulsão foi desenvolvida por método de homogeneização sob alta agitação, e apresentou em sua caracterização diâmetro médio variando entre 72 – 80 nm, PDI inferior a 0,3, potencial zeta -6,2mV e pH ácido. Para sua aplicação em massagem e aromaterapia, diluições foram feitas dentro da faixa de concentração segura para uso, em óleo carreador de amêndoas doces. Análise morfológica demonstrou que as gotículas da nanoemulsão estavam presentes e sem sinal de degradação, quando diluídas em óleo carreador, após 30 dias. Como forma de avaliar o potencial irritante, as formulações puras e diluídas no carreador foram avaliadas em método de HET-CAM, as quais se mostraram seguras quando em concentração de óleo essencial abaixo de 5%. Por fim, após o ensaio clínico, os participantes que receberam o óleo essencial de L. dentata tiveram diferença significativa na melhora da qualidade do sono em comparação àqueles que receberam de intervenção a nanoemulsão e o placebo (p=0,011). Os resultados obtidos dessa intervenção sugerem que ensaios mais adequados são necessários para avaliar a liberação dos compostos ativos da nanoemulsão desenvolvida, quando também diluída em óleo carreador para aplicação tópica. Entretanto destaca-se o efeito sedativo da L. dentata, aplicada de forma combinada via inalatória e tópica, como potencial tratamento para a má qualidade do sono.Submitted by Clarice Rosa Machado (clarice.machado@ufn.edu.br) on 2023-05-31T18:14:36Z No. of bitstreams: 3 Dissertacao_RuthBarin_SemAssinaturas.pdf: 1488826 bytes, checksum: d138c45b6ac477697d7128a21f7a79c1 (MD5) Dissertacao_RuthBarin_VersaoParcial.pdf: 1075817 bytes, checksum: 987c7b8d06f41ca932c29f67e200c2ea (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Made available in DSpace on 2023-05-31T18:14:36Z (GMT). No. of bitstreams: 3 Dissertacao_RuthBarin_SemAssinaturas.pdf: 1488826 bytes, checksum: d138c45b6ac477697d7128a21f7a79c1 (MD5) Dissertacao_RuthBarin_VersaoParcial.pdf: 1075817 bytes, checksum: 987c7b8d06f41ca932c29f67e200c2ea (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2023-02-27CAPESapplication/pdfhttp://www.tede.universidadefranciscana.edu.br:8080/retrieve/10650/Dissertacao_RuthBarin_SemAssinaturas.pdf.jpghttp://www.tede.universidadefranciscana.edu.br:8080/retrieve/10658/Dissertacao_RuthBarin_VersaoParcial.pdf.jpgporUniversidade FranciscanaPrograma de Pós-Graduação em NanociênciasUFNBrasilBiociências e Nanomateriaishttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/embargoedAccessLavandula dentata, nanoemulsão, óleos essenciais, insônia.Lavandula dentata, nanoemulsion, essential oils, insomnia.InterdisciplinarNANOEMULSÕES CONTENDO ÓLEO ESSENCIAL DE LAVANDULA DENTATA: DESENVOLVIMENTO E AVALIAÇÃO DA IRRITAÇÃO CUTÂNEA E DA EFICÁCIA NO TRATAMENTO DA INSÔNIAinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisreponame:Repositório Institucional Universidade Franciscanainstname:Universidade Franciscana (UFN)instacron:UFNTHUMBNAILDissertacao_RuthBarin_SemAssinaturas.pdf.jpgDissertacao_RuthBarin_SemAssinaturas.pdf.jpgimage/jpeg3876http://tede.universidadefranciscana.edu.br:8080/bitstream/UFN-BDTD/1174/8/Dissertacao_RuthBarin_SemAssinaturas.pdf.jpg1ab293f230ea5c7813fd3038cb4bb16fMD58Dissertacao_RuthBarin_VersaoParcial.pdf.jpgDissertacao_RuthBarin_VersaoParcial.pdf.jpgimage/jpeg3876http://tede.universidadefranciscana.edu.br:8080/bitstream/UFN-BDTD/1174/10/Dissertacao_RuthBarin_VersaoParcial.pdf.jpg1ab293f230ea5c7813fd3038cb4bb16fMD510TEXTDissertacao_RuthBarin_SemAssinaturas.pdf.txtDissertacao_RuthBarin_SemAssinaturas.pdf.txttext/plain120469http://tede.universidadefranciscana.edu.br:8080/bitstream/UFN-BDTD/1174/7/Dissertacao_RuthBarin_SemAssinaturas.pdf.txt0b8a91eedca926d9b20147199ffea06aMD57Dissertacao_RuthBarin_VersaoParcial.pdf.txtDissertacao_RuthBarin_VersaoParcial.pdf.txttext/plain100417http://tede.universidadefranciscana.edu.br:8080/bitstream/UFN-BDTD/1174/9/Dissertacao_RuthBarin_VersaoParcial.pdf.txtbad9de0cbb212818df9ab21ea9da31acMD59ORIGINALDissertacao_RuthBarin_SemAssinaturas.pdfDissertacao_RuthBarin_SemAssinaturas.pdfapplication/pdf1488826http://tede.universidadefranciscana.edu.br:8080/bitstream/UFN-BDTD/1174/5/Dissertacao_RuthBarin_SemAssinaturas.pdfd138c45b6ac477697d7128a21f7a79c1MD55Dissertacao_RuthBarin_VersaoParcial.pdfDissertacao_RuthBarin_VersaoParcial.pdfapplication/pdf1075817http://tede.universidadefranciscana.edu.br:8080/bitstream/UFN-BDTD/1174/6/Dissertacao_RuthBarin_VersaoParcial.pdf987c7b8d06f41ca932c29f67e200c2eaMD56CC-LICENSElicense_urllicense_urltext/plain; charset=utf-849http://tede.universidadefranciscana.edu.br:8080/bitstream/UFN-BDTD/1174/2/license_url4afdbb8c545fd630ea7db775da747b2fMD52license_textlicense_texttext/html; charset=utf-80http://tede.universidadefranciscana.edu.br:8080/bitstream/UFN-BDTD/1174/3/license_textd41d8cd98f00b204e9800998ecf8427eMD53license_rdflicense_rdfapplication/rdf+xml; charset=utf-80http://tede.universidadefranciscana.edu.br:8080/bitstream/UFN-BDTD/1174/4/license_rdfd41d8cd98f00b204e9800998ecf8427eMD54LICENSElicense.txtlicense.txttext/plain; charset=utf-8310http://tede.universidadefranciscana.edu.br:8080/bitstream/UFN-BDTD/1174/1/license.txt7dc66ddb96829ff34b56b1a92c851bcdMD51UFN-BDTD/11742023-06-02 01:00:11.755oai:tede.universidadefranciscana.edu.br:UFN-BDTD/1174RXN0ZSB0cmFiYWxobyBzZXLDoSBsaWNlbmNpYWRvIHNvYiBhIExpY2Vuw6dhIEF0cmlidWnDp8Ojby1Ow6NvQ29tZXJjaWFsLVNlbURlcml2YcOnw7VlcyA0LjAgSW50ZXJuYWNpb25hbCBDcmVhdGl2ZSBDb21tb25zLiBQYXJhIHZpc3VhbGl6YXIgdW1hIGPDs3BpYSBkZXN0YSBsaWNlbsOnYSwgdmlzaXRlIGh0dHA6Ly9jcmVhdGl2ZWNvbW1vbnMub3JnL2xpY2Vuc2VzL2J5LW5jLW5kLzQuMC8gb3UgbWFuZGUgdW1hIGNhcnRhIHBhcmEgQ3JlYXRpdmUgQ29tbW9ucywgUE8gQm94IDE4NjYsIE1vdW50YWluIFZpZXcsIENBIDk0MDQyLCBVU0EuCg==Repositório de Publicaçõeshttp://www.tede.universidadefranciscana.edu.br:8080/http://www.tede.universidadefranciscana.edu.br:8080/oai/requestopendoar:2023-06-02T04:00:11Repositório Institucional Universidade Franciscana - Universidade Franciscana (UFN)false
dc.title.por.fl_str_mv NANOEMULSÕES CONTENDO ÓLEO ESSENCIAL DE LAVANDULA DENTATA: DESENVOLVIMENTO E AVALIAÇÃO DA IRRITAÇÃO CUTÂNEA E DA EFICÁCIA NO TRATAMENTO DA INSÔNIA
title NANOEMULSÕES CONTENDO ÓLEO ESSENCIAL DE LAVANDULA DENTATA: DESENVOLVIMENTO E AVALIAÇÃO DA IRRITAÇÃO CUTÂNEA E DA EFICÁCIA NO TRATAMENTO DA INSÔNIA
spellingShingle NANOEMULSÕES CONTENDO ÓLEO ESSENCIAL DE LAVANDULA DENTATA: DESENVOLVIMENTO E AVALIAÇÃO DA IRRITAÇÃO CUTÂNEA E DA EFICÁCIA NO TRATAMENTO DA INSÔNIA
Barin, Ruth
Lavandula dentata, nanoemulsão, óleos essenciais, insônia.
Lavandula dentata, nanoemulsion, essential oils, insomnia.
Interdisciplinar
title_short NANOEMULSÕES CONTENDO ÓLEO ESSENCIAL DE LAVANDULA DENTATA: DESENVOLVIMENTO E AVALIAÇÃO DA IRRITAÇÃO CUTÂNEA E DA EFICÁCIA NO TRATAMENTO DA INSÔNIA
title_full NANOEMULSÕES CONTENDO ÓLEO ESSENCIAL DE LAVANDULA DENTATA: DESENVOLVIMENTO E AVALIAÇÃO DA IRRITAÇÃO CUTÂNEA E DA EFICÁCIA NO TRATAMENTO DA INSÔNIA
title_fullStr NANOEMULSÕES CONTENDO ÓLEO ESSENCIAL DE LAVANDULA DENTATA: DESENVOLVIMENTO E AVALIAÇÃO DA IRRITAÇÃO CUTÂNEA E DA EFICÁCIA NO TRATAMENTO DA INSÔNIA
title_full_unstemmed NANOEMULSÕES CONTENDO ÓLEO ESSENCIAL DE LAVANDULA DENTATA: DESENVOLVIMENTO E AVALIAÇÃO DA IRRITAÇÃO CUTÂNEA E DA EFICÁCIA NO TRATAMENTO DA INSÔNIA
title_sort NANOEMULSÕES CONTENDO ÓLEO ESSENCIAL DE LAVANDULA DENTATA: DESENVOLVIMENTO E AVALIAÇÃO DA IRRITAÇÃO CUTÂNEA E DA EFICÁCIA NO TRATAMENTO DA INSÔNIA
author Barin, Ruth
author_facet Barin, Ruth
author_role author
dc.contributor.advisor1.fl_str_mv Ourique , Aline Ferreira
dc.contributor.advisor-co1.fl_str_mv Nedel, Sheila Spohr
dc.contributor.referee1.fl_str_mv Silva, Wiliam Leonardo da
dc.contributor.referee2.fl_str_mv Contri , Renata Vidor
dc.contributor.author.fl_str_mv Barin, Ruth
contributor_str_mv Ourique , Aline Ferreira
Nedel, Sheila Spohr
Silva, Wiliam Leonardo da
Contri , Renata Vidor
dc.subject.por.fl_str_mv Lavandula dentata, nanoemulsão, óleos essenciais, insônia.
topic Lavandula dentata, nanoemulsão, óleos essenciais, insônia.
Lavandula dentata, nanoemulsion, essential oils, insomnia.
Interdisciplinar
dc.subject.eng.fl_str_mv Lavandula dentata, nanoemulsion, essential oils, insomnia.
dc.subject.cnpq.fl_str_mv Interdisciplinar
description Poor sleep quality can cause several changes and symptoms such as anxiety, reduced cognitive capacity and fatigue, changes that are aggravated during the period of the Covid-19 pandemic. In a non-drug approach, because it is more accessible and has fewer adverse effects, the use of essential oils is popularized as a treatment for various disorders, including insomnia. Lavender essential oil, one of the most commercialized worldwide, is widely used for its calming and sedative therapeutic properties. However, Lavandula dentata still has scarce studies to evaluate its sedative effect when compared to other species. Essential oils also have some limitations, such as low solubility in water and photosensitivity, which can be overcome when combined with nanotechnology. In this context, the objective of this study was to develop nanoemulsions containing essential oil of L. dentata, to evaluate the skin irritation in vitro, and its therapeutic effect in vivo through a clinical trial with the aim of treating self-reported insomnia in adults, with topical application. (massage) and inhalation (aromatherapy) of the oil in its free and nanemulsified form. The nanoemulsion was developed by high agitation method, and presented in its characterization an average diameter varying between 72 – 80 nm, PDI lower than 0.3, zeta potential -6,2mV and acidic pH. For its application in massage and aromatherapy, dilutions were made within the safe concentration range for use, in sweet almond carrier oil. Morphological analysis showed that the nanoemulsion droplets were present and without signs of degradation, when diluted in carrier oil, after 30 days. As a way of evaluating the irritant potential, the pure and diluted formulations in the carrier were evaluated in the HET-CAM method, which proved to be safe when in essential oil concentrations below 5%. Finally, after the clinical trial, the participants who received the essential oil of L. dentata had a significant difference in the improvement of sleep quality compared to those who received the nanoemulsion and placebo intervention (p=0.011). The results obtained from this intervention suggest that more adequate tests are needed to evaluate the release of active compounds from the developed nanoemulsion, when also diluted in carrier oil for topical application. However, the sedative effect of L. dentata, applied in combination via inhalation and topically, stands out as a potential treatment for poor sleep quality.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-05-31T18:14:36Z
dc.date.issued.fl_str_mv 2023-02-27
dc.date.available.fl_str_mv 2024-05-23
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv Barin, Ruth. NANOEMULSÕES CONTENDO ÓLEO ESSENCIAL DE LAVANDULA DENTATA: DESENVOLVIMENTO E AVALIAÇÃO DA IRRITAÇÃO CUTÂNEA E DA EFICÁCIA NO TRATAMENTO DA INSÔNIA. 2023. 78f. Dissertação( Programa de Pós-Graduação em Nanociências) - Universidade Franciscana, Santa Maria - RS.
dc.identifier.uri.fl_str_mv http://www.tede.universidadefranciscana.edu.br:8080/handle/UFN-BDTD/1174
identifier_str_mv Barin, Ruth. NANOEMULSÕES CONTENDO ÓLEO ESSENCIAL DE LAVANDULA DENTATA: DESENVOLVIMENTO E AVALIAÇÃO DA IRRITAÇÃO CUTÂNEA E DA EFICÁCIA NO TRATAMENTO DA INSÔNIA. 2023. 78f. Dissertação( Programa de Pós-Graduação em Nanociências) - Universidade Franciscana, Santa Maria - RS.
url http://www.tede.universidadefranciscana.edu.br:8080/handle/UFN-BDTD/1174
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/embargoedAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Franciscana
dc.publisher.program.fl_str_mv Programa de Pós-Graduação em Nanociências
dc.publisher.initials.fl_str_mv UFN
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv Biociências e Nanomateriais
publisher.none.fl_str_mv Universidade Franciscana
dc.source.none.fl_str_mv reponame:Repositório Institucional Universidade Franciscana
instname:Universidade Franciscana (UFN)
instacron:UFN
instname_str Universidade Franciscana (UFN)
instacron_str UFN
institution UFN
reponame_str Repositório Institucional Universidade Franciscana
collection Repositório Institucional Universidade Franciscana
bitstream.url.fl_str_mv http://tede.universidadefranciscana.edu.br:8080/bitstream/UFN-BDTD/1174/8/Dissertacao_RuthBarin_SemAssinaturas.pdf.jpg
http://tede.universidadefranciscana.edu.br:8080/bitstream/UFN-BDTD/1174/10/Dissertacao_RuthBarin_VersaoParcial.pdf.jpg
http://tede.universidadefranciscana.edu.br:8080/bitstream/UFN-BDTD/1174/7/Dissertacao_RuthBarin_SemAssinaturas.pdf.txt
http://tede.universidadefranciscana.edu.br:8080/bitstream/UFN-BDTD/1174/9/Dissertacao_RuthBarin_VersaoParcial.pdf.txt
http://tede.universidadefranciscana.edu.br:8080/bitstream/UFN-BDTD/1174/5/Dissertacao_RuthBarin_SemAssinaturas.pdf
http://tede.universidadefranciscana.edu.br:8080/bitstream/UFN-BDTD/1174/6/Dissertacao_RuthBarin_VersaoParcial.pdf
http://tede.universidadefranciscana.edu.br:8080/bitstream/UFN-BDTD/1174/2/license_url
http://tede.universidadefranciscana.edu.br:8080/bitstream/UFN-BDTD/1174/3/license_text
http://tede.universidadefranciscana.edu.br:8080/bitstream/UFN-BDTD/1174/4/license_rdf
http://tede.universidadefranciscana.edu.br:8080/bitstream/UFN-BDTD/1174/1/license.txt
bitstream.checksum.fl_str_mv 1ab293f230ea5c7813fd3038cb4bb16f
1ab293f230ea5c7813fd3038cb4bb16f
0b8a91eedca926d9b20147199ffea06a
bad9de0cbb212818df9ab21ea9da31ac
d138c45b6ac477697d7128a21f7a79c1
987c7b8d06f41ca932c29f67e200c2ea
4afdbb8c545fd630ea7db775da747b2f
d41d8cd98f00b204e9800998ecf8427e
d41d8cd98f00b204e9800998ecf8427e
7dc66ddb96829ff34b56b1a92c851bcd
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
MD5
MD5
MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional Universidade Franciscana - Universidade Franciscana (UFN)
repository.mail.fl_str_mv
_version_ 1801046212783112192