Urinary albumin excretion rate and glomerular filtration rate in single-kidney type 2 diabetic patients

• Autor(a) principal: P. Silveiro, Sandra
• Data de Publicação: 2022
• Outros Autores: da Costa, Luciana, O. Beck, Maristela, L. Gross, Jorge
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Clinical and Biomedical Research
• Texto Completo: https://seer.ufrgs.br/index.php/hcpa/article/view/124653

OBJECTIVE: To evaluate the urinary albumin excretion rate and the glomerular filtrationrate of single-kidney type 2 diabetic patients and of single-kidney nondiabetic patients.PATIENTS AND METHODS: Patients who had only one kidney for at least 5 years,with no renal disease or hypertension at the time of the nephrectomy and with nocalculus or systemic disease at the time of the evaluation, were included in thiscontrolled cross-sectional study. A total of 20 single-kidney type 2 diabetic patients(eight men, age 62 ± 9 years; diabetes duration 8.5 ± 7 years), 17 single-kidneynondiabetic patients (two men, age 57 ± 13 years), and 184 type 2 diabetic patientswho were matched to the single-kidney diabetic group for age, sex and body massindex were studied. Urinary albumin excretion rate was measured byimmunoturbidimetry in timed 24-h sterile urine, and glomerular filtration rate wasdetermined by the 51CrEDTA single-injection method.RESULTS: Single-kidney type 2 diabetic patients presented a higher proportion (eightof 20; 40%) of microalbuminuria (urinary albumin excretion rate 20-200 mg/min)than single-kidney nondiabetic patients (three of 17; 17.6%) and type 2 diabetic patients(37 of 184; 20%). Single-kidney diabetic patients presented a higher proportion ofmacroalbuminuria (urinary albumin excretion rate >200 mg/min; six of 20; 30%) thansingle-kidney nondiabetic patients (one of 17; 6%) but were similar to type 2 diabeticpatients (43 of 184; 23%). The glomerular filtration rates of normaoalbuminuric singlekidney nondiabetic patients (71.7 ± 21.4 ml × min-1 × 1.73 m-2 ) and single-kidney type2 diabetic patients (73.0 ± 21.5 ml × min-1 × 1.73 m-2 ) were similar but higher than theone-kidney glomerular filtration rate (GFR¸ 2) of the age-, sex-, and body massindex-matched normoalbuminiric type 2 diabetic patients (54.0 ± 11.6ml × min-1 ×1.73m-2).CONCLUSIONS: Increased GFR related to single-kidney status confers an increasedrisk of developing renal disease in the presence of diabetes.