Urinary albumin excretion rate and glomerular filtration rate in single-kidney type 2 diabetic patients
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinical and Biomedical Research |
Texto Completo: | https://seer.ufrgs.br/index.php/hcpa/article/view/124653 |
Resumo: | OBJECTIVE: To evaluate the urinary albumin excretion rate and the glomerular filtrationrate of single-kidney type 2 diabetic patients and of single-kidney nondiabetic patients.PATIENTS AND METHODS: Patients who had only one kidney for at least 5 years,with no renal disease or hypertension at the time of the nephrectomy and with nocalculus or systemic disease at the time of the evaluation, were included in thiscontrolled cross-sectional study. A total of 20 single-kidney type 2 diabetic patients(eight men, age 62 ± 9 years; diabetes duration 8.5 ± 7 years), 17 single-kidneynondiabetic patients (two men, age 57 ± 13 years), and 184 type 2 diabetic patientswho were matched to the single-kidney diabetic group for age, sex and body massindex were studied. Urinary albumin excretion rate was measured byimmunoturbidimetry in timed 24-h sterile urine, and glomerular filtration rate wasdetermined by the 51CrEDTA single-injection method.RESULTS: Single-kidney type 2 diabetic patients presented a higher proportion (eightof 20; 40%) of microalbuminuria (urinary albumin excretion rate 20-200 mg/min)than single-kidney nondiabetic patients (three of 17; 17.6%) and type 2 diabetic patients(37 of 184; 20%). Single-kidney diabetic patients presented a higher proportion ofmacroalbuminuria (urinary albumin excretion rate >200 mg/min; six of 20; 30%) thansingle-kidney nondiabetic patients (one of 17; 6%) but were similar to type 2 diabeticpatients (43 of 184; 23%). The glomerular filtration rates of normaoalbuminuric singlekidney nondiabetic patients (71.7 ± 21.4 ml × min-1 × 1.73 m-2 ) and single-kidney type2 diabetic patients (73.0 ± 21.5 ml × min-1 × 1.73 m-2 ) were similar but higher than theone-kidney glomerular filtration rate (GFR¸ 2) of the age-, sex-, and body massindex-matched normoalbuminiric type 2 diabetic patients (54.0 ± 11.6ml × min-1 ×1.73m-2).CONCLUSIONS: Increased GFR related to single-kidney status confers an increasedrisk of developing renal disease in the presence of diabetes. |
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Urinary albumin excretion rate and glomerular filtration rate in single-kidney type 2 diabetic patientsTaxa de excreção urinária de albumina e taxa de filtração glomerular em pacientes com diabetes tipo 2 e apenas um rimOBJECTIVE: To evaluate the urinary albumin excretion rate and the glomerular filtrationrate of single-kidney type 2 diabetic patients and of single-kidney nondiabetic patients.PATIENTS AND METHODS: Patients who had only one kidney for at least 5 years,with no renal disease or hypertension at the time of the nephrectomy and with nocalculus or systemic disease at the time of the evaluation, were included in thiscontrolled cross-sectional study. A total of 20 single-kidney type 2 diabetic patients(eight men, age 62 ± 9 years; diabetes duration 8.5 ± 7 years), 17 single-kidneynondiabetic patients (two men, age 57 ± 13 years), and 184 type 2 diabetic patientswho were matched to the single-kidney diabetic group for age, sex and body massindex were studied. Urinary albumin excretion rate was measured byimmunoturbidimetry in timed 24-h sterile urine, and glomerular filtration rate wasdetermined by the 51CrEDTA single-injection method.RESULTS: Single-kidney type 2 diabetic patients presented a higher proportion (eightof 20; 40%) of microalbuminuria (urinary albumin excretion rate 20-200 mg/min)than single-kidney nondiabetic patients (three of 17; 17.6%) and type 2 diabetic patients(37 of 184; 20%). Single-kidney diabetic patients presented a higher proportion ofmacroalbuminuria (urinary albumin excretion rate >200 mg/min; six of 20; 30%) thansingle-kidney nondiabetic patients (one of 17; 6%) but were similar to type 2 diabeticpatients (43 of 184; 23%). The glomerular filtration rates of normaoalbuminuric singlekidney nondiabetic patients (71.7 ± 21.4 ml × min-1 × 1.73 m-2 ) and single-kidney type2 diabetic patients (73.0 ± 21.5 ml × min-1 × 1.73 m-2 ) were similar but higher than theone-kidney glomerular filtration rate (GFR¸ 2) of the age-, sex-, and body massindex-matched normoalbuminiric type 2 diabetic patients (54.0 ± 11.6ml × min-1 ×1.73m-2).CONCLUSIONS: Increased GFR related to single-kidney status confers an increasedrisk of developing renal disease in the presence of diabetes.OBJETIVO: Avaliar a taxa de excreção urinária de albumina e a taxa defiltração glomerular em pacientes com apenas um rim e diabetes tipo 2 e empacientes não-diabéticos com apenas um rim. PACIENTES E MÉTODOS: Foi feito um estudo controlado, de cortetransversal. Este estudo incluiu pacientes que tivessem apenas um rim por,pelo menos, 5 anos, que não apresentaram doenças renais ou hipertensãoquando da nefroctomia, e que não tivessem cálculo ou doença sistêmicaquando da avaliação. Foram avaliados 20 pacientes com apenas um rim ediabetes tipo 2 (oito homens, idade 62 + 9 anos; duração da diabete 8,5 + 7anos), 17 pacientes não-diabéticos com apenas um rim (dois homens, idade57 + 13 anos), e 184 pacientes com diabetes tipo 2, que foram agrupadospor idade, sexo e índice de massa corporal com os pacientes diabéticoscom apenas um rim. A taxa de excreção urinária de albumina foi medida porimunoturbidimetria através de coletas de urina esterilizada obtidas a cada24 h. A taxa de filtração glomerular foi determinada pelo método 51Cr-EDTAde injeção única.RESULTADOS: Os pacientes com diabetes tipo 2 e apenas um rimapresentaram uma proporção maior (oito em 20; 40%) de microalbumnuria(taxa de excreção urinária de albumina 20-200 mg/min) do que os pacientesnão-diabéticos e com apenas um rim (três em 17; 17,6%) e do que ospacientes diabéticos do tipo 2 (37 em 184, 20%). Pacientes diabéticos comapenas um rim apresentaram uma proporção maior de macroalbuminuria(taxa de excreção urinária de albumina>200 mg/min; seis em 20; 30%) doque os pacientes não-diabéticos e com apenas um rim (um em 17; 6%),mas semelhante à mesma proporção dos pacientes com diabetes tipo 2 (43em 184; 23%). As taxas de filtração glomerular dos pacientes não-diabéticose normoalbuminúricos com apenas um rim (71,7 + 21,4 ml x min-1 x 1,73m2), e de pacientes com diabetes tipo 2 e apenas um rim (73,0 + 21,5 ml x min1 x1,73m-2) foram semelhantes. No entanto, estas foram mais elevadas doque a taxa de filtração glomerular (TFR ¸ 2) dos pacientes com diabetes tipo2 e normoalbuminúricos, agrupados por idade, sexo e índice de massacorporal (54,0 + 11,6 ml x min-1 x 1,73m-2).CONCLUSÕES: Uma TFR elevada, associada à condição de um único rim,confere um aumento do risco de desenvolvimento de doença renal napresença de diabetes.HCPA/FAMED/UFRGS2022-05-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionA Convite dos Editoresapplication/pdfhttps://seer.ufrgs.br/index.php/hcpa/article/view/124653Clinical & Biomedical Research; Vol. 18 No. 2 (1998): Revista HCPAClinical and Biomedical Research; v. 18 n. 2 (1998): Revista HCPA2357-9730reponame:Clinical and Biomedical Researchinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSenghttps://seer.ufrgs.br/index.php/hcpa/article/view/124653/84915http://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccess P. Silveiro, Sandrada Costa, Luciana O. Beck, Maristela L. Gross, Jorge2022-09-16T16:32:21Zoai:seer.ufrgs.br:article/124653Revistahttps://www.seer.ufrgs.br/index.php/hcpaPUBhttps://seer.ufrgs.br/index.php/hcpa/oai||cbr@hcpa.edu.br2357-97302357-9730opendoar:2022-09-16T16:32:21Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.none.fl_str_mv |
Urinary albumin excretion rate and glomerular filtration rate in single-kidney type 2 diabetic patients Taxa de excreção urinária de albumina e taxa de filtração glomerular em pacientes com diabetes tipo 2 e apenas um rim |
title |
Urinary albumin excretion rate and glomerular filtration rate in single-kidney type 2 diabetic patients |
spellingShingle |
Urinary albumin excretion rate and glomerular filtration rate in single-kidney type 2 diabetic patients P. Silveiro, Sandra |
title_short |
Urinary albumin excretion rate and glomerular filtration rate in single-kidney type 2 diabetic patients |
title_full |
Urinary albumin excretion rate and glomerular filtration rate in single-kidney type 2 diabetic patients |
title_fullStr |
Urinary albumin excretion rate and glomerular filtration rate in single-kidney type 2 diabetic patients |
title_full_unstemmed |
Urinary albumin excretion rate and glomerular filtration rate in single-kidney type 2 diabetic patients |
title_sort |
Urinary albumin excretion rate and glomerular filtration rate in single-kidney type 2 diabetic patients |
author |
P. Silveiro, Sandra |
author_facet |
P. Silveiro, Sandra da Costa, Luciana O. Beck, Maristela L. Gross, Jorge |
author_role |
author |
author2 |
da Costa, Luciana O. Beck, Maristela L. Gross, Jorge |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
P. Silveiro, Sandra da Costa, Luciana O. Beck, Maristela L. Gross, Jorge |
description |
OBJECTIVE: To evaluate the urinary albumin excretion rate and the glomerular filtrationrate of single-kidney type 2 diabetic patients and of single-kidney nondiabetic patients.PATIENTS AND METHODS: Patients who had only one kidney for at least 5 years,with no renal disease or hypertension at the time of the nephrectomy and with nocalculus or systemic disease at the time of the evaluation, were included in thiscontrolled cross-sectional study. A total of 20 single-kidney type 2 diabetic patients(eight men, age 62 ± 9 years; diabetes duration 8.5 ± 7 years), 17 single-kidneynondiabetic patients (two men, age 57 ± 13 years), and 184 type 2 diabetic patientswho were matched to the single-kidney diabetic group for age, sex and body massindex were studied. Urinary albumin excretion rate was measured byimmunoturbidimetry in timed 24-h sterile urine, and glomerular filtration rate wasdetermined by the 51CrEDTA single-injection method.RESULTS: Single-kidney type 2 diabetic patients presented a higher proportion (eightof 20; 40%) of microalbuminuria (urinary albumin excretion rate 20-200 mg/min)than single-kidney nondiabetic patients (three of 17; 17.6%) and type 2 diabetic patients(37 of 184; 20%). Single-kidney diabetic patients presented a higher proportion ofmacroalbuminuria (urinary albumin excretion rate >200 mg/min; six of 20; 30%) thansingle-kidney nondiabetic patients (one of 17; 6%) but were similar to type 2 diabeticpatients (43 of 184; 23%). The glomerular filtration rates of normaoalbuminuric singlekidney nondiabetic patients (71.7 ± 21.4 ml × min-1 × 1.73 m-2 ) and single-kidney type2 diabetic patients (73.0 ± 21.5 ml × min-1 × 1.73 m-2 ) were similar but higher than theone-kidney glomerular filtration rate (GFR¸ 2) of the age-, sex-, and body massindex-matched normoalbuminiric type 2 diabetic patients (54.0 ± 11.6ml × min-1 ×1.73m-2).CONCLUSIONS: Increased GFR related to single-kidney status confers an increasedrisk of developing renal disease in the presence of diabetes. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-05-25 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion A Convite dos Editores |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://seer.ufrgs.br/index.php/hcpa/article/view/124653 |
url |
https://seer.ufrgs.br/index.php/hcpa/article/view/124653 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://seer.ufrgs.br/index.php/hcpa/article/view/124653/84915 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
HCPA/FAMED/UFRGS |
publisher.none.fl_str_mv |
HCPA/FAMED/UFRGS |
dc.source.none.fl_str_mv |
Clinical & Biomedical Research; Vol. 18 No. 2 (1998): Revista HCPA Clinical and Biomedical Research; v. 18 n. 2 (1998): Revista HCPA 2357-9730 reponame:Clinical and Biomedical Research instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Clinical and Biomedical Research |
collection |
Clinical and Biomedical Research |
repository.name.fl_str_mv |
Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
||cbr@hcpa.edu.br |
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1799767056771448832 |