Androgen receptor CAG polymorphism and the risk of benign prostatic hyperplasia in a Brazilian population
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/119119 |
Resumo: | Benign prostatic hyperplasia (BPH) is a very frequent age-related proliferative abnormality in men. Polymorphic CAG repeat in the androgen receptor (AR) can alter transactivation of androgen-responsive genes and potentially infl uence BPH risk. We investigated the association between CAG repeat length and risk of BPH in a case-control study of a Brazilian population. We evaluated 214 patients; 126 with BPH and 88 healthy controls. DNA was extracted from peripheral leucocytes and the AR gene was analyzed using fragment analysis. Hazard ratio (HR) and 95% confi dence interval were estimated using logistic regression models. Mean CAG length was not different between patients with BPH and controls. The CAG repeat length was examined as a categorical variable (CAG ≤ 21 vs. CAG > 21 and CAG ≤ 22 vs. CAG > 22) and did not differ between the control vs. the BPH group. We found no evidence for an association between AR CAG repeat length in BPH risk in a population-based sample of Brazilians |
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Biolchi, VanderleiSilva Neto, BrasilKoff, Walter JoseBrum, Ilma Simoni2015-07-11T02:00:17Z20121677-6119http://hdl.handle.net/10183/119119000964015Benign prostatic hyperplasia (BPH) is a very frequent age-related proliferative abnormality in men. Polymorphic CAG repeat in the androgen receptor (AR) can alter transactivation of androgen-responsive genes and potentially infl uence BPH risk. We investigated the association between CAG repeat length and risk of BPH in a case-control study of a Brazilian population. We evaluated 214 patients; 126 with BPH and 88 healthy controls. DNA was extracted from peripheral leucocytes and the AR gene was analyzed using fragment analysis. Hazard ratio (HR) and 95% confi dence interval were estimated using logistic regression models. Mean CAG length was not different between patients with BPH and controls. The CAG repeat length was examined as a categorical variable (CAG ≤ 21 vs. CAG > 21 and CAG ≤ 22 vs. CAG > 22) and did not differ between the control vs. the BPH group. We found no evidence for an association between AR CAG repeat length in BPH risk in a population-based sample of Braziliansapplication/pdfengInternational brazilian journal of urology. Rio de Janeiro, RJ. Vol. 38, no. 3 (May/June 2012), p. 373-379Receptores androgênicosPolimorfismo genéticoHiperplasia prostáticaAndrogen receptor CAG polymorphism and the risk of benign prostatic hyperplasia in a Brazilian populationinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000964015.pdf000964015.pdfTexto completo (inglês)application/pdf212642http://www.lume.ufrgs.br/bitstream/10183/119119/1/000964015.pdf591afb0ee950f58c8d9937e4bd1f9992MD51TEXT000964015.pdf.txt000964015.pdf.txtExtracted Texttext/plain23441http://www.lume.ufrgs.br/bitstream/10183/119119/2/000964015.pdf.txt00c7ba48a20a75da7f6de5baa54131beMD52THUMBNAIL000964015.pdf.jpg000964015.pdf.jpgGenerated Thumbnailimage/jpeg2052http://www.lume.ufrgs.br/bitstream/10183/119119/3/000964015.pdf.jpg4b2e2c09eb63cd036b8d748938405ab1MD5310183/1191192019-01-11 04:10:40.139938oai:www.lume.ufrgs.br:10183/119119Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-01-11T06:10:40Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Androgen receptor CAG polymorphism and the risk of benign prostatic hyperplasia in a Brazilian population |
title |
Androgen receptor CAG polymorphism and the risk of benign prostatic hyperplasia in a Brazilian population |
spellingShingle |
Androgen receptor CAG polymorphism and the risk of benign prostatic hyperplasia in a Brazilian population Biolchi, Vanderlei Receptores androgênicos Polimorfismo genético Hiperplasia prostática |
title_short |
Androgen receptor CAG polymorphism and the risk of benign prostatic hyperplasia in a Brazilian population |
title_full |
Androgen receptor CAG polymorphism and the risk of benign prostatic hyperplasia in a Brazilian population |
title_fullStr |
Androgen receptor CAG polymorphism and the risk of benign prostatic hyperplasia in a Brazilian population |
title_full_unstemmed |
Androgen receptor CAG polymorphism and the risk of benign prostatic hyperplasia in a Brazilian population |
title_sort |
Androgen receptor CAG polymorphism and the risk of benign prostatic hyperplasia in a Brazilian population |
author |
Biolchi, Vanderlei |
author_facet |
Biolchi, Vanderlei Silva Neto, Brasil Koff, Walter Jose Brum, Ilma Simoni |
author_role |
author |
author2 |
Silva Neto, Brasil Koff, Walter Jose Brum, Ilma Simoni |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Biolchi, Vanderlei Silva Neto, Brasil Koff, Walter Jose Brum, Ilma Simoni |
dc.subject.por.fl_str_mv |
Receptores androgênicos Polimorfismo genético Hiperplasia prostática |
topic |
Receptores androgênicos Polimorfismo genético Hiperplasia prostática |
description |
Benign prostatic hyperplasia (BPH) is a very frequent age-related proliferative abnormality in men. Polymorphic CAG repeat in the androgen receptor (AR) can alter transactivation of androgen-responsive genes and potentially infl uence BPH risk. We investigated the association between CAG repeat length and risk of BPH in a case-control study of a Brazilian population. We evaluated 214 patients; 126 with BPH and 88 healthy controls. DNA was extracted from peripheral leucocytes and the AR gene was analyzed using fragment analysis. Hazard ratio (HR) and 95% confi dence interval were estimated using logistic regression models. Mean CAG length was not different between patients with BPH and controls. The CAG repeat length was examined as a categorical variable (CAG ≤ 21 vs. CAG > 21 and CAG ≤ 22 vs. CAG > 22) and did not differ between the control vs. the BPH group. We found no evidence for an association between AR CAG repeat length in BPH risk in a population-based sample of Brazilians |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
dc.date.accessioned.fl_str_mv |
2015-07-11T02:00:17Z |
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info:eu-repo/semantics/article info:eu-repo/semantics/other |
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http://hdl.handle.net/10183/119119 |
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1677-6119 |
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000964015 |
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1677-6119 000964015 |
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http://hdl.handle.net/10183/119119 |
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eng |
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dc.relation.ispartof.pt_BR.fl_str_mv |
International brazilian journal of urology. Rio de Janeiro, RJ. Vol. 38, no. 3 (May/June 2012), p. 373-379 |
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openAccess |
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