Association between diabetes and cognitive function at baseline in the Brazilian Longitudinal Study of Adult Health (ELSA- Brasil)
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/223294 |
Resumo: | Diabetes has been associated with cognitive changes and an increased risk of vascular dementia and Alzheimer’s disease, but it is unclear whether there are associations between diabetes and early alterations in cognitive performance. The present study consisted of a cross-section analysis of 14,444 participants aged 35–74 years and from a developing country at baseline in the Brazilian Longitudinal Study of Adult Health (ELSA–Brasil); these participants were recruited between 2008 and 2010. We investigated whether there was an association between diabetes and early changes in the cognitive performance of this Brazilian population. To assess cognitive domains, we used the word-list learning, word-list delayed recall and word recognition tests along. Phonemic verbal fuency tests included semantic phonemic test (animals) and a phonemic test (words beginning with the letter F). Executive functions associated with attention, concentration and psychomotor speed were evaluated using the Trail Making Test B. The exposure variable in the study was defned as diabetes. Multiple linear regression was used to estimate the association between diabetes and cognitive performance. The results were adjusted for age, sex, education, hypertension, coronary disease, depression, physical activity, smoking, alcohol consumption, and the cholesterol/HDL-C ratio. We found a signifcant association between diabetes and decreased memory, language and executive function (attention, concentration and psychomotor speed) performance in this population from a country with a distinct epidemiological profle, even after adjusting for the main intervening variables. |
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Teixeira, Mônica MariaPassos, Valéria Maria de AzeredoBarreto, Sandhi MariaSchmidt, Maria InêsDuncan, Bruce BartholowBeleigoli, Alline Maria RezendeFonseca, Maria J. M.Vidigal, Pedro GuatimosimAraújo, Larissa FortunatoDiniz, Maria de Fátima Haueisen Sander2021-07-06T04:47:08Z20202045-2322http://hdl.handle.net/10183/223294001126491Diabetes has been associated with cognitive changes and an increased risk of vascular dementia and Alzheimer’s disease, but it is unclear whether there are associations between diabetes and early alterations in cognitive performance. The present study consisted of a cross-section analysis of 14,444 participants aged 35–74 years and from a developing country at baseline in the Brazilian Longitudinal Study of Adult Health (ELSA–Brasil); these participants were recruited between 2008 and 2010. We investigated whether there was an association between diabetes and early changes in the cognitive performance of this Brazilian population. To assess cognitive domains, we used the word-list learning, word-list delayed recall and word recognition tests along. Phonemic verbal fuency tests included semantic phonemic test (animals) and a phonemic test (words beginning with the letter F). Executive functions associated with attention, concentration and psychomotor speed were evaluated using the Trail Making Test B. The exposure variable in the study was defned as diabetes. Multiple linear regression was used to estimate the association between diabetes and cognitive performance. The results were adjusted for age, sex, education, hypertension, coronary disease, depression, physical activity, smoking, alcohol consumption, and the cholesterol/HDL-C ratio. We found a signifcant association between diabetes and decreased memory, language and executive function (attention, concentration and psychomotor speed) performance in this population from a country with a distinct epidemiological profle, even after adjusting for the main intervening variables.application/pdfengScientific reports. London. Vol. 10 (2020), 1596, 10 p.Diabetes mellitusCogniçãoAdultoSaúdeBrasilAssociation between diabetes and cognitive function at baseline in the Brazilian Longitudinal Study of Adult Health (ELSA- Brasil)Estrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001126491.pdf.txt001126491.pdf.txtExtracted Texttext/plain51491http://www.lume.ufrgs.br/bitstream/10183/223294/2/001126491.pdf.txt1945253e71c4b63e5f4433aac0fd6939MD52ORIGINAL001126491.pdfTexto completo (inglês)application/pdf1009826http://www.lume.ufrgs.br/bitstream/10183/223294/1/001126491.pdfd71d7ed838a2323a99413e442b499fbcMD5110183/2232942021-08-04 04:51:26.822654oai:www.lume.ufrgs.br:10183/223294Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-08-04T07:51:26Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Association between diabetes and cognitive function at baseline in the Brazilian Longitudinal Study of Adult Health (ELSA- Brasil) |
title |
Association between diabetes and cognitive function at baseline in the Brazilian Longitudinal Study of Adult Health (ELSA- Brasil) |
spellingShingle |
Association between diabetes and cognitive function at baseline in the Brazilian Longitudinal Study of Adult Health (ELSA- Brasil) Teixeira, Mônica Maria Diabetes mellitus Cognição Adulto Saúde Brasil |
title_short |
Association between diabetes and cognitive function at baseline in the Brazilian Longitudinal Study of Adult Health (ELSA- Brasil) |
title_full |
Association between diabetes and cognitive function at baseline in the Brazilian Longitudinal Study of Adult Health (ELSA- Brasil) |
title_fullStr |
Association between diabetes and cognitive function at baseline in the Brazilian Longitudinal Study of Adult Health (ELSA- Brasil) |
title_full_unstemmed |
Association between diabetes and cognitive function at baseline in the Brazilian Longitudinal Study of Adult Health (ELSA- Brasil) |
title_sort |
Association between diabetes and cognitive function at baseline in the Brazilian Longitudinal Study of Adult Health (ELSA- Brasil) |
author |
Teixeira, Mônica Maria |
author_facet |
Teixeira, Mônica Maria Passos, Valéria Maria de Azeredo Barreto, Sandhi Maria Schmidt, Maria Inês Duncan, Bruce Bartholow Beleigoli, Alline Maria Rezende Fonseca, Maria J. M. Vidigal, Pedro Guatimosim Araújo, Larissa Fortunato Diniz, Maria de Fátima Haueisen Sander |
author_role |
author |
author2 |
Passos, Valéria Maria de Azeredo Barreto, Sandhi Maria Schmidt, Maria Inês Duncan, Bruce Bartholow Beleigoli, Alline Maria Rezende Fonseca, Maria J. M. Vidigal, Pedro Guatimosim Araújo, Larissa Fortunato Diniz, Maria de Fátima Haueisen Sander |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Teixeira, Mônica Maria Passos, Valéria Maria de Azeredo Barreto, Sandhi Maria Schmidt, Maria Inês Duncan, Bruce Bartholow Beleigoli, Alline Maria Rezende Fonseca, Maria J. M. Vidigal, Pedro Guatimosim Araújo, Larissa Fortunato Diniz, Maria de Fátima Haueisen Sander |
dc.subject.por.fl_str_mv |
Diabetes mellitus Cognição Adulto Saúde Brasil |
topic |
Diabetes mellitus Cognição Adulto Saúde Brasil |
description |
Diabetes has been associated with cognitive changes and an increased risk of vascular dementia and Alzheimer’s disease, but it is unclear whether there are associations between diabetes and early alterations in cognitive performance. The present study consisted of a cross-section analysis of 14,444 participants aged 35–74 years and from a developing country at baseline in the Brazilian Longitudinal Study of Adult Health (ELSA–Brasil); these participants were recruited between 2008 and 2010. We investigated whether there was an association between diabetes and early changes in the cognitive performance of this Brazilian population. To assess cognitive domains, we used the word-list learning, word-list delayed recall and word recognition tests along. Phonemic verbal fuency tests included semantic phonemic test (animals) and a phonemic test (words beginning with the letter F). Executive functions associated with attention, concentration and psychomotor speed were evaluated using the Trail Making Test B. The exposure variable in the study was defned as diabetes. Multiple linear regression was used to estimate the association between diabetes and cognitive performance. The results were adjusted for age, sex, education, hypertension, coronary disease, depression, physical activity, smoking, alcohol consumption, and the cholesterol/HDL-C ratio. We found a signifcant association between diabetes and decreased memory, language and executive function (attention, concentration and psychomotor speed) performance in this population from a country with a distinct epidemiological profle, even after adjusting for the main intervening variables. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020 |
dc.date.accessioned.fl_str_mv |
2021-07-06T04:47:08Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10183/223294 |
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2045-2322 |
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001126491 |
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http://hdl.handle.net/10183/223294 |
dc.language.iso.fl_str_mv |
eng |
language |
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dc.relation.ispartof.pt_BR.fl_str_mv |
Scientific reports. London. Vol. 10 (2020), 1596, 10 p. |
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info:eu-repo/semantics/openAccess |
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openAccess |
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