Survival and predictors of death in tuberculosis/HIV coinfection cases in Porto Alegre, Brazil : a historical cohort from 2009 to 2013
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/232425 |
Resumo: | Background: Tuberculosis is a curable disease, which remains the leading cause of death among infectious diseases worldwide, and it is the leading cause of death in people living with HIV. The purpose is to examine survival and predictors of death in Tuberculosis/HIV coinfection cases from 2009 to 2013. Methods: We estimated the survival of 2,417 TB/HIV coinfection cases in Porto Alegre, from diagnosis up to 85 months of follow-up. We estimated hazard ratios and survival curves. Results: The adjusted risk ratio (aRR) for death, by age, hospitalization, and Directly Observed Treatment was 4.58 for new cases (95% CI: 1.14–18.4), 4.51 for recurrence (95% CI: 1.11–18.4) and 4.53 for return after abandonment (95% CI: 1.12–18.4). The average survival time was 72.56 ± 1.57 months for those who underwent Directly Observed Treatment and 62.61 ± 0.77 for those who did not. Conclusions: Case classification, age, and hospitalization are predictors of death. The occurrence of Directly Observed Treatment was a protective factor that increased the probability of survival. Policies aimed at reducing the mortality of patients with TB/HIV coinfection are needed. |
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Brand, Évelin MariaRossetto, MaíraHentges, BrunaWinkler, Gerson BarretoDuarte, Êrica Rosalba MallmannSilva, Lucas Cardoso daLeal, Andrea FachelKnauth, Daniela RivaSilva, Danielle LodiMantese, George Henrique AliattiVolpato, Tiane FariasBobek, Paulo RicardoDellanhese, Amanda Pereira FerreiraTeixeira, Luciana Barcellos2021-12-01T04:35:40Z20212767-3375http://hdl.handle.net/10183/232425001134290Background: Tuberculosis is a curable disease, which remains the leading cause of death among infectious diseases worldwide, and it is the leading cause of death in people living with HIV. The purpose is to examine survival and predictors of death in Tuberculosis/HIV coinfection cases from 2009 to 2013. Methods: We estimated the survival of 2,417 TB/HIV coinfection cases in Porto Alegre, from diagnosis up to 85 months of follow-up. We estimated hazard ratios and survival curves. Results: The adjusted risk ratio (aRR) for death, by age, hospitalization, and Directly Observed Treatment was 4.58 for new cases (95% CI: 1.14–18.4), 4.51 for recurrence (95% CI: 1.11–18.4) and 4.53 for return after abandonment (95% CI: 1.12–18.4). The average survival time was 72.56 ± 1.57 months for those who underwent Directly Observed Treatment and 62.61 ± 0.77 for those who did not. Conclusions: Case classification, age, and hospitalization are predictors of death. The occurrence of Directly Observed Treatment was a protective factor that increased the probability of survival. Policies aimed at reducing the mortality of patients with TB/HIV coinfection are needed.application/pdfengPLOS Global Public Health. San Francisco, California, USA. Vol. 1, n. 11 (10 Nov. 2021), e0000051, p. 1-11TuberculoseHIVMortePorto Alegre (RS) : Aspectos sociaisSurvival and predictors of death in tuberculosis/HIV coinfection cases in Porto Alegre, Brazil : a historical cohort from 2009 to 2013Estrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001134290.pdf.txt001134290.pdf.txtExtracted Texttext/plain38204http://www.lume.ufrgs.br/bitstream/10183/232425/2/001134290.pdf.txtd03795a264b82f5e1ab8a2b381c42a57MD52ORIGINAL001134290.pdfTexto completo (inglês)application/pdf721673http://www.lume.ufrgs.br/bitstream/10183/232425/1/001134290.pdf833ddb1619dae6478970114e1f5850e0MD5110183/2324252023-09-21 03:40:38.135195oai:www.lume.ufrgs.br:10183/232425Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-09-21T06:40:38Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Survival and predictors of death in tuberculosis/HIV coinfection cases in Porto Alegre, Brazil : a historical cohort from 2009 to 2013 |
title |
Survival and predictors of death in tuberculosis/HIV coinfection cases in Porto Alegre, Brazil : a historical cohort from 2009 to 2013 |
spellingShingle |
Survival and predictors of death in tuberculosis/HIV coinfection cases in Porto Alegre, Brazil : a historical cohort from 2009 to 2013 Brand, Évelin Maria Tuberculose HIV Morte Porto Alegre (RS) : Aspectos sociais |
title_short |
Survival and predictors of death in tuberculosis/HIV coinfection cases in Porto Alegre, Brazil : a historical cohort from 2009 to 2013 |
title_full |
Survival and predictors of death in tuberculosis/HIV coinfection cases in Porto Alegre, Brazil : a historical cohort from 2009 to 2013 |
title_fullStr |
Survival and predictors of death in tuberculosis/HIV coinfection cases in Porto Alegre, Brazil : a historical cohort from 2009 to 2013 |
title_full_unstemmed |
Survival and predictors of death in tuberculosis/HIV coinfection cases in Porto Alegre, Brazil : a historical cohort from 2009 to 2013 |
title_sort |
Survival and predictors of death in tuberculosis/HIV coinfection cases in Porto Alegre, Brazil : a historical cohort from 2009 to 2013 |
author |
Brand, Évelin Maria |
author_facet |
Brand, Évelin Maria Rossetto, Maíra Hentges, Bruna Winkler, Gerson Barreto Duarte, Êrica Rosalba Mallmann Silva, Lucas Cardoso da Leal, Andrea Fachel Knauth, Daniela Riva Silva, Danielle Lodi Mantese, George Henrique Aliatti Volpato, Tiane Farias Bobek, Paulo Ricardo Dellanhese, Amanda Pereira Ferreira Teixeira, Luciana Barcellos |
author_role |
author |
author2 |
Rossetto, Maíra Hentges, Bruna Winkler, Gerson Barreto Duarte, Êrica Rosalba Mallmann Silva, Lucas Cardoso da Leal, Andrea Fachel Knauth, Daniela Riva Silva, Danielle Lodi Mantese, George Henrique Aliatti Volpato, Tiane Farias Bobek, Paulo Ricardo Dellanhese, Amanda Pereira Ferreira Teixeira, Luciana Barcellos |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Brand, Évelin Maria Rossetto, Maíra Hentges, Bruna Winkler, Gerson Barreto Duarte, Êrica Rosalba Mallmann Silva, Lucas Cardoso da Leal, Andrea Fachel Knauth, Daniela Riva Silva, Danielle Lodi Mantese, George Henrique Aliatti Volpato, Tiane Farias Bobek, Paulo Ricardo Dellanhese, Amanda Pereira Ferreira Teixeira, Luciana Barcellos |
dc.subject.por.fl_str_mv |
Tuberculose HIV Morte Porto Alegre (RS) : Aspectos sociais |
topic |
Tuberculose HIV Morte Porto Alegre (RS) : Aspectos sociais |
description |
Background: Tuberculosis is a curable disease, which remains the leading cause of death among infectious diseases worldwide, and it is the leading cause of death in people living with HIV. The purpose is to examine survival and predictors of death in Tuberculosis/HIV coinfection cases from 2009 to 2013. Methods: We estimated the survival of 2,417 TB/HIV coinfection cases in Porto Alegre, from diagnosis up to 85 months of follow-up. We estimated hazard ratios and survival curves. Results: The adjusted risk ratio (aRR) for death, by age, hospitalization, and Directly Observed Treatment was 4.58 for new cases (95% CI: 1.14–18.4), 4.51 for recurrence (95% CI: 1.11–18.4) and 4.53 for return after abandonment (95% CI: 1.12–18.4). The average survival time was 72.56 ± 1.57 months for those who underwent Directly Observed Treatment and 62.61 ± 0.77 for those who did not. Conclusions: Case classification, age, and hospitalization are predictors of death. The occurrence of Directly Observed Treatment was a protective factor that increased the probability of survival. Policies aimed at reducing the mortality of patients with TB/HIV coinfection are needed. |
publishDate |
2021 |
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2021-12-01T04:35:40Z |
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2021 |
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001134290 |
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PLOS Global Public Health. San Francisco, California, USA. Vol. 1, n. 11 (10 Nov. 2021), e0000051, p. 1-11 |
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