Heterogeneous trajectories in schizophrenia : insights from neurodevelopment and neuroprogression models
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/255590 |
Resumo: | The notion that schizophrenia is a neuroprogressive disorder is based on clinical perception of cumulative impairments over time and is supported by neuroimaging and biomarker research. Nevertheless, increasing evidence has indicated that schizophrenia first emerges as a neurodevelopmental disorder that could follow various pathways, some of them neuroprogressive. The objective of this review is to revisit basic research on cognitive processes and neuroimaging findings in a search for candidate keys to the intricate connections between neurodevelopment and neuroprogression in schizophrenia. In the complete panorama, schizophrenia is a neurodevelopmental disorder, possibly associated with an additional burden over the course of the disease through pathologically accelerated aging, and cognitive heterogeneity may explain the different trajectories of each patient. |
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Reckziegel, Ramiro de Freitas XavierCzepielewski, Letícia SanguinettiSousa, Mathias Hasse deMartins, Dayane SantosBritto, Maria J. deLapa, Clara de OliveiraSchwartzhaupt, Alexandre WilliGama, Clarissa Severino2023-03-11T03:28:17Z20221516-4446http://hdl.handle.net/10183/255590001162615The notion that schizophrenia is a neuroprogressive disorder is based on clinical perception of cumulative impairments over time and is supported by neuroimaging and biomarker research. Nevertheless, increasing evidence has indicated that schizophrenia first emerges as a neurodevelopmental disorder that could follow various pathways, some of them neuroprogressive. The objective of this review is to revisit basic research on cognitive processes and neuroimaging findings in a search for candidate keys to the intricate connections between neurodevelopment and neuroprogression in schizophrenia. In the complete panorama, schizophrenia is a neurodevelopmental disorder, possibly associated with an additional burden over the course of the disease through pathologically accelerated aging, and cognitive heterogeneity may explain the different trajectories of each patient.application/pdfengRevista brasileira de psiquiatria (1999). São Paulo. Vol. 44, n. 1 (jan./feb. 2022), p. 74-80EsquizofreniaEnvelhecimentoProcessos cognitivosSchizophreniaCognitionAgingNeurodevelopmentNeuroprogressionHeterogeneous trajectories in schizophrenia : insights from neurodevelopment and neuroprogression modelsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001162615.pdf.txt001162615.pdf.txtExtracted Texttext/plain44210http://www.lume.ufrgs.br/bitstream/10183/255590/2/001162615.pdf.txt0e41a3c07209fe979155f1ab6660c9b2MD52ORIGINAL001162615.pdfTexto completo (inglês)application/pdf169615http://www.lume.ufrgs.br/bitstream/10183/255590/1/001162615.pdff2599fa9598bd6a9abe30c9f47d1a074MD5110183/2555902023-03-12 03:23:40.769361oai:www.lume.ufrgs.br:10183/255590Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-03-12T06:23:40Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Heterogeneous trajectories in schizophrenia : insights from neurodevelopment and neuroprogression models |
title |
Heterogeneous trajectories in schizophrenia : insights from neurodevelopment and neuroprogression models |
spellingShingle |
Heterogeneous trajectories in schizophrenia : insights from neurodevelopment and neuroprogression models Reckziegel, Ramiro de Freitas Xavier Esquizofrenia Envelhecimento Processos cognitivos Schizophrenia Cognition Aging Neurodevelopment Neuroprogression |
title_short |
Heterogeneous trajectories in schizophrenia : insights from neurodevelopment and neuroprogression models |
title_full |
Heterogeneous trajectories in schizophrenia : insights from neurodevelopment and neuroprogression models |
title_fullStr |
Heterogeneous trajectories in schizophrenia : insights from neurodevelopment and neuroprogression models |
title_full_unstemmed |
Heterogeneous trajectories in schizophrenia : insights from neurodevelopment and neuroprogression models |
title_sort |
Heterogeneous trajectories in schizophrenia : insights from neurodevelopment and neuroprogression models |
author |
Reckziegel, Ramiro de Freitas Xavier |
author_facet |
Reckziegel, Ramiro de Freitas Xavier Czepielewski, Letícia Sanguinetti Sousa, Mathias Hasse de Martins, Dayane Santos Britto, Maria J. de Lapa, Clara de Oliveira Schwartzhaupt, Alexandre Willi Gama, Clarissa Severino |
author_role |
author |
author2 |
Czepielewski, Letícia Sanguinetti Sousa, Mathias Hasse de Martins, Dayane Santos Britto, Maria J. de Lapa, Clara de Oliveira Schwartzhaupt, Alexandre Willi Gama, Clarissa Severino |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Reckziegel, Ramiro de Freitas Xavier Czepielewski, Letícia Sanguinetti Sousa, Mathias Hasse de Martins, Dayane Santos Britto, Maria J. de Lapa, Clara de Oliveira Schwartzhaupt, Alexandre Willi Gama, Clarissa Severino |
dc.subject.por.fl_str_mv |
Esquizofrenia Envelhecimento Processos cognitivos |
topic |
Esquizofrenia Envelhecimento Processos cognitivos Schizophrenia Cognition Aging Neurodevelopment Neuroprogression |
dc.subject.eng.fl_str_mv |
Schizophrenia Cognition Aging Neurodevelopment Neuroprogression |
description |
The notion that schizophrenia is a neuroprogressive disorder is based on clinical perception of cumulative impairments over time and is supported by neuroimaging and biomarker research. Nevertheless, increasing evidence has indicated that schizophrenia first emerges as a neurodevelopmental disorder that could follow various pathways, some of them neuroprogressive. The objective of this review is to revisit basic research on cognitive processes and neuroimaging findings in a search for candidate keys to the intricate connections between neurodevelopment and neuroprogression in schizophrenia. In the complete panorama, schizophrenia is a neurodevelopmental disorder, possibly associated with an additional burden over the course of the disease through pathologically accelerated aging, and cognitive heterogeneity may explain the different trajectories of each patient. |
publishDate |
2022 |
dc.date.issued.fl_str_mv |
2022 |
dc.date.accessioned.fl_str_mv |
2023-03-11T03:28:17Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
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info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/255590 |
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1516-4446 |
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001162615 |
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url |
http://hdl.handle.net/10183/255590 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Revista brasileira de psiquiatria (1999). São Paulo. Vol. 44, n. 1 (jan./feb. 2022), p. 74-80 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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