Brain derived neurotrophic factor mediated learning, fear acquisition and extinction as targets for developing novel treatments for anxiety

Detalhes bibliográficos
Autor(a) principal: Oliveira,Karina Soares de
Data de Publicação: 2016
Outros Autores: Hounie,Ana Gabriela, Cappi,Carolina, Diniz,Juliana Belo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0047-20852016000300251
Resumo: ABSTRACT Anxiety and obsessive-compulsive related disorders are highly prevalent and disabling disorders for which there are still treatment gaps to be explored. Fear is a core symptom of these disorders and its learning is highly dependent on the activity of the neurotrophin brain-derived neurotrophic factor (BDNF). Should BDNF-mediated fear learning be considered a target for the development of novel treatments for anxiety and obsessive-compulsive related disorders? We review the evidence that suggests that BDNF expression is necessary for the acquisition of conditioned fear, as well as for the recall of its extinction. We describe the findings related to fear learning and genetic/epigenetic manipulation of Bdnf expression in animals and BDNF allelic variants in humans. Later, we discuss how manipulation of BDNF levels represents a promising potential treatment target that may increase the benefits of therapies that extinguish previously conditioned fear.
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spelling Brain derived neurotrophic factor mediated learning, fear acquisition and extinction as targets for developing novel treatments for anxietyBrain-derived neurotrophic factorfearanxiety disorderslearningpsychological extinctionABSTRACT Anxiety and obsessive-compulsive related disorders are highly prevalent and disabling disorders for which there are still treatment gaps to be explored. Fear is a core symptom of these disorders and its learning is highly dependent on the activity of the neurotrophin brain-derived neurotrophic factor (BDNF). Should BDNF-mediated fear learning be considered a target for the development of novel treatments for anxiety and obsessive-compulsive related disorders? We review the evidence that suggests that BDNF expression is necessary for the acquisition of conditioned fear, as well as for the recall of its extinction. We describe the findings related to fear learning and genetic/epigenetic manipulation of Bdnf expression in animals and BDNF allelic variants in humans. Later, we discuss how manipulation of BDNF levels represents a promising potential treatment target that may increase the benefits of therapies that extinguish previously conditioned fear.Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro2016-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0047-20852016000300251Jornal Brasileiro de Psiquiatria v.65 n.3 2016reponame:Jornal Brasileiro de Psiquiatria (Online)instname:Universidade Federal do Rio de Janeiro (UFRJ)instacron:UFRJ10.1590/0047-2085000000132info:eu-repo/semantics/openAccessOliveira,Karina Soares deHounie,Ana GabrielaCappi,CarolinaDiniz,Juliana Beloeng2016-11-07T00:00:00Zoai:scielo:S0047-20852016000300251Revistahttp://portalrev.enfermagem.bvs.br/index.php?issn=0047-2085&lang=ptONGhttps://old.scielo.br/oai/scielo-oai.php||editora@ipub.ufrj.br1982-02080047-2085opendoar:2016-11-07T00:00Jornal Brasileiro de Psiquiatria (Online) - Universidade Federal do Rio de Janeiro (UFRJ)false
dc.title.none.fl_str_mv Brain derived neurotrophic factor mediated learning, fear acquisition and extinction as targets for developing novel treatments for anxiety
title Brain derived neurotrophic factor mediated learning, fear acquisition and extinction as targets for developing novel treatments for anxiety
spellingShingle Brain derived neurotrophic factor mediated learning, fear acquisition and extinction as targets for developing novel treatments for anxiety
Oliveira,Karina Soares de
Brain-derived neurotrophic factor
fear
anxiety disorders
learning
psychological extinction
title_short Brain derived neurotrophic factor mediated learning, fear acquisition and extinction as targets for developing novel treatments for anxiety
title_full Brain derived neurotrophic factor mediated learning, fear acquisition and extinction as targets for developing novel treatments for anxiety
title_fullStr Brain derived neurotrophic factor mediated learning, fear acquisition and extinction as targets for developing novel treatments for anxiety
title_full_unstemmed Brain derived neurotrophic factor mediated learning, fear acquisition and extinction as targets for developing novel treatments for anxiety
title_sort Brain derived neurotrophic factor mediated learning, fear acquisition and extinction as targets for developing novel treatments for anxiety
author Oliveira,Karina Soares de
author_facet Oliveira,Karina Soares de
Hounie,Ana Gabriela
Cappi,Carolina
Diniz,Juliana Belo
author_role author
author2 Hounie,Ana Gabriela
Cappi,Carolina
Diniz,Juliana Belo
author2_role author
author
author
dc.contributor.author.fl_str_mv Oliveira,Karina Soares de
Hounie,Ana Gabriela
Cappi,Carolina
Diniz,Juliana Belo
dc.subject.por.fl_str_mv Brain-derived neurotrophic factor
fear
anxiety disorders
learning
psychological extinction
topic Brain-derived neurotrophic factor
fear
anxiety disorders
learning
psychological extinction
description ABSTRACT Anxiety and obsessive-compulsive related disorders are highly prevalent and disabling disorders for which there are still treatment gaps to be explored. Fear is a core symptom of these disorders and its learning is highly dependent on the activity of the neurotrophin brain-derived neurotrophic factor (BDNF). Should BDNF-mediated fear learning be considered a target for the development of novel treatments for anxiety and obsessive-compulsive related disorders? We review the evidence that suggests that BDNF expression is necessary for the acquisition of conditioned fear, as well as for the recall of its extinction. We describe the findings related to fear learning and genetic/epigenetic manipulation of Bdnf expression in animals and BDNF allelic variants in humans. Later, we discuss how manipulation of BDNF levels represents a promising potential treatment target that may increase the benefits of therapies that extinguish previously conditioned fear.
publishDate 2016
dc.date.none.fl_str_mv 2016-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0047-20852016000300251
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0047-20852016000300251
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0047-2085000000132
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro
publisher.none.fl_str_mv Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro
dc.source.none.fl_str_mv Jornal Brasileiro de Psiquiatria v.65 n.3 2016
reponame:Jornal Brasileiro de Psiquiatria (Online)
instname:Universidade Federal do Rio de Janeiro (UFRJ)
instacron:UFRJ
instname_str Universidade Federal do Rio de Janeiro (UFRJ)
instacron_str UFRJ
institution UFRJ
reponame_str Jornal Brasileiro de Psiquiatria (Online)
collection Jornal Brasileiro de Psiquiatria (Online)
repository.name.fl_str_mv Jornal Brasileiro de Psiquiatria (Online) - Universidade Federal do Rio de Janeiro (UFRJ)
repository.mail.fl_str_mv ||editora@ipub.ufrj.br
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