Efeitos da dieta hiperlipídica suplementada com óleos vegetais nos parâmetros metabólicos e inflamatórios em ratos Wistar
Autor(a) principal: | |
---|---|
Data de Publicação: | 2013 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional Manancial UFSM |
Texto Completo: | http://repositorio.ufsm.br/handle/1/5740 |
Resumo: | The consumption of trans fat is strongly associated to the development of cardiovascular disease (CVD) by its action on plasma lipids and because they act in an inflammatory processes; besides, vegetable oils are used by population to prevent these kind of disease. The objective of this research was to determine the effect of consuming a high fat diet supplemented with coconut oil, avocado oil and chia oil in inflammatory and metabolic parameters in wistar rats. After seven days in adjustment period, 35 male Wistar rats received a standard diet for 45 days (TC), hyperlipidemic diet and coconut oil (DHCO), hyperlipidemic diet and avocado oil (DHAB) and hyperlipidemic diet and chia oil (DHCH), by gavage in the amount of 0.8 mL/kg body weight. The diet consumption and serum TG levels were higher in TC. Liver weight was higher in groups DHCO and DHAB, with no statistical difference between groups (p <0.05) considering weight gain, epididymal fat weight and TC, HDL and LDL serum levels. Higher plasma concentrations of IL-1, IL-6, TNF-α and IFN-γ were found in the groups DHSF, DHCO and DHAB and lower in TC and DHCH groups. The IL-10 was higher in the group DHCH. In the morphometric analysis, the DHCH group showed increase on the cell number and reduction on their cytoplasm area. The intervention on the hyperlipidemic diet consumption with trans fatty acid allowed to observe that the lipid profile is preceded by a systemic inflammatory environment, which is modulated by the omega-3 fatty acid (α-linolenic acid), present in chia oil, which reversed this scene, but does not override the consumption of a balanced diet observed by the TC group. This proves that dietary intervention to prevent CVD must be associated to appropriate choices of lipid intake, maintaining an adequate intake of omega-3, as evidenced in this paper by the decrease of pro-inflammatory cytokines (IL-1, IL -6, TNF-α and IFN-γ) and IL-10 increased, which is considered anti-inflammatory. |
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2017-03-062017-03-062013-05-29GRESSLER, Camila Costa. EFFECTS OF HYPERLIPIDEMIC DIET SUPLEMENTED WITH VEGETABLE OILS IN METABOLIC AND INFLAMMATORY PARAMETERS IN WISTAR RATS. 2013. 65 f. Dissertação (Mestrado em Ciência e Tecnologia dos Alimentos) - Universidade Federal de Santa Maria, Santa Maria, 2013.http://repositorio.ufsm.br/handle/1/5740The consumption of trans fat is strongly associated to the development of cardiovascular disease (CVD) by its action on plasma lipids and because they act in an inflammatory processes; besides, vegetable oils are used by population to prevent these kind of disease. The objective of this research was to determine the effect of consuming a high fat diet supplemented with coconut oil, avocado oil and chia oil in inflammatory and metabolic parameters in wistar rats. After seven days in adjustment period, 35 male Wistar rats received a standard diet for 45 days (TC), hyperlipidemic diet and coconut oil (DHCO), hyperlipidemic diet and avocado oil (DHAB) and hyperlipidemic diet and chia oil (DHCH), by gavage in the amount of 0.8 mL/kg body weight. The diet consumption and serum TG levels were higher in TC. Liver weight was higher in groups DHCO and DHAB, with no statistical difference between groups (p <0.05) considering weight gain, epididymal fat weight and TC, HDL and LDL serum levels. Higher plasma concentrations of IL-1, IL-6, TNF-α and IFN-γ were found in the groups DHSF, DHCO and DHAB and lower in TC and DHCH groups. The IL-10 was higher in the group DHCH. In the morphometric analysis, the DHCH group showed increase on the cell number and reduction on their cytoplasm area. The intervention on the hyperlipidemic diet consumption with trans fatty acid allowed to observe that the lipid profile is preceded by a systemic inflammatory environment, which is modulated by the omega-3 fatty acid (α-linolenic acid), present in chia oil, which reversed this scene, but does not override the consumption of a balanced diet observed by the TC group. This proves that dietary intervention to prevent CVD must be associated to appropriate choices of lipid intake, maintaining an adequate intake of omega-3, as evidenced in this paper by the decrease of pro-inflammatory cytokines (IL-1, IL -6, TNF-α and IFN-γ) and IL-10 increased, which is considered anti-inflammatory.O consumo de gordura trans é fortemente associado ao desenvolvimento de doenças cardiovasculares (DCV) por sua ação sobre os lipídios plasmáticos e por atuarem em processos inflamatórios, sendo que os óleos vegetais são utilizados pela população para a prevenção dessas doenças. O objetivo deste trabalho foi determinar o efeito do consumo de dieta hiperlipídica suplementada com óleo de coco, óleo de abacate e óleo de chia nos parâmetros metabólicos e inflamatórios em ratos wistar. Após sete dias em período de adaptação, 35 ratos wistar machos receberam por 45 dias dieta padrão (TC), dieta hiperlipídica e soro fisiológico (DHSF), dieta hiperlipídica e óleo de coco (DHCO), dieta hiperlipídica e óleo de abacate (DHAB) e dieta hiperlipídica e óleo de chia (DHCH), sendo que os óleos foram ofertados por gavagem na quantidade de 0,8 mL/kg de peso corporal. O consumo da dieta e níveis séricos de TG foram maiores no TC. O peso do fígado foi maior nos grupos DHCO e DHAB, sendo que não houve diferença estatística entre os grupos (p< 0,05) quanto ao ganho de peso, peso de gordura epididimal e níveis séricos de CT, HDL e LDL. Concentrações plasmáticas mais elevadas de IL-1, IL-6, TNF-α e IFN-γ foram encontradas nos grupos DHSF, DHCO e DHAB e as menores nos grupos TC e DHCH. A IL-10 foi maior no grupo DHCH. Na análise morfométrica, o grupo DHCH apresentou aumento do número de células e redução na área do citoplasma das mesmas. A intervenção do consumo de dieta hiperlipídica com ácido graxo trans permitiu observar que a alteração do perfil lipídico é precedida de um ambiente inflamatório sistêmico, o qual é modulado pelo ácido graxo ômega 3 (α-linolênico), presente no óleo de chia, o qual reverteu este quadro, mas não sobrepõe-se ao consumo de uma dieta equilibrada observada pelo grupo TC. Isto comprova que a intervenção dietética para prevenir a ocorrência de DCV deve estar associada a escolhas adequadas da ingestão de lipídios, mantendo um aporte adequado de ácido graxo ômega-3, evidenciado no trabalho pela diminuição das citocinas pró-inflamatórias (IL-1, IL-6, TNF-α e IFN-γ) e aumento da IL-10 considerada anti-inflamatória.application/pdfporUniversidade Federal de Santa MariaPrograma de Pós-Graduação em Ciência e Tecnologia dos AlimentosUFSMBRCiência e Tecnologia dos AlimentosÁcidos graxosCitocinasÓleo cocoÓleo abacateÓleo chiaPerfil lipídicoMormofetria de fígadoGanho pesoConsumo de dietaFatty acidsCytokinesCoconut oilAvocado oilChia oilLipid profileMorphometria of liverWeight gainDiet consumptionCNPQ::CIENCIAS AGRARIAS::CIENCIA E TECNOLOGIA DE ALIMENTOSEfeitos da dieta hiperlipídica suplementada com óleos vegetais nos parâmetros metabólicos e inflamatórios em ratos WistarEffects of hyperlipidemic diet suplemented with vegetable oils in metabolic and inflammatory parameters in Wistar ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisHecktheuer, Luisa Helena Rycheckihttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4793145U5Callegaro, Maria da Graça Kolinskihttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4762908U5Morgan-martins, Maria Isabelhttp://lattes.cnpq.br/0372820116852027http://lattes.cnpq.br/4711764363187583Gressler, Camila Costa500700000006400500300300300be82ea16-ac55-4d7d-83a6-8701ea1bb7a6e2717ad5-dc8a-43b8-872f-a092eed49bbfcc3695af-4366-4905-80c9-b7762ceb791ade8d9aaa-f2bd-45a2-8978-a58f11ab9651info:eu-repo/semantics/openAccessreponame:Repositório Institucional Manancial UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALGRESSLER, CAMILA COSTA.pdfapplication/pdf3033494http://repositorio.ufsm.br/bitstream/1/5740/1/GRESSLER%2c%20CAMILA%20COSTA.pdf2f1b7dda68a53f43abae3dc273c7c1aeMD51TEXTGRESSLER, CAMILA COSTA.pdf.txtGRESSLER, CAMILA COSTA.pdf.txtExtracted texttext/plain116435http://repositorio.ufsm.br/bitstream/1/5740/2/GRESSLER%2c%20CAMILA%20COSTA.pdf.txt5ed6bcb2763cff112e8ee5ab74eeda34MD52THUMBNAILGRESSLER, CAMILA COSTA.pdf.jpgGRESSLER, CAMILA COSTA.pdf.jpgIM Thumbnailimage/jpeg5164http://repositorio.ufsm.br/bitstream/1/5740/3/GRESSLER%2c%20CAMILA%20COSTA.pdf.jpg72602e70c75e26d26ec631d1b65a3d87MD531/57402021-12-30 11:06:08.432oai:repositorio.ufsm.br:1/5740Repositório Institucionalhttp://repositorio.ufsm.br/PUBhttp://repositorio.ufsm.br/oai/requestouvidoria@ufsm.bropendoar:39132021-12-30T14:06:08Repositório Institucional Manancial UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.por.fl_str_mv |
Efeitos da dieta hiperlipídica suplementada com óleos vegetais nos parâmetros metabólicos e inflamatórios em ratos Wistar |
dc.title.alternative.eng.fl_str_mv |
Effects of hyperlipidemic diet suplemented with vegetable oils in metabolic and inflammatory parameters in Wistar rats |
title |
Efeitos da dieta hiperlipídica suplementada com óleos vegetais nos parâmetros metabólicos e inflamatórios em ratos Wistar |
spellingShingle |
Efeitos da dieta hiperlipídica suplementada com óleos vegetais nos parâmetros metabólicos e inflamatórios em ratos Wistar Gressler, Camila Costa Ácidos graxos Citocinas Óleo coco Óleo abacate Óleo chia Perfil lipídico Mormofetria de fígado Ganho peso Consumo de dieta Fatty acids Cytokines Coconut oil Avocado oil Chia oil Lipid profile Morphometria of liver Weight gain Diet consumption CNPQ::CIENCIAS AGRARIAS::CIENCIA E TECNOLOGIA DE ALIMENTOS |
title_short |
Efeitos da dieta hiperlipídica suplementada com óleos vegetais nos parâmetros metabólicos e inflamatórios em ratos Wistar |
title_full |
Efeitos da dieta hiperlipídica suplementada com óleos vegetais nos parâmetros metabólicos e inflamatórios em ratos Wistar |
title_fullStr |
Efeitos da dieta hiperlipídica suplementada com óleos vegetais nos parâmetros metabólicos e inflamatórios em ratos Wistar |
title_full_unstemmed |
Efeitos da dieta hiperlipídica suplementada com óleos vegetais nos parâmetros metabólicos e inflamatórios em ratos Wistar |
title_sort |
Efeitos da dieta hiperlipídica suplementada com óleos vegetais nos parâmetros metabólicos e inflamatórios em ratos Wistar |
author |
Gressler, Camila Costa |
author_facet |
Gressler, Camila Costa |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Hecktheuer, Luisa Helena Rychecki |
dc.contributor.advisor1Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4793145U5 |
dc.contributor.referee1.fl_str_mv |
Callegaro, Maria da Graça Kolinski |
dc.contributor.referee1Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4762908U5 |
dc.contributor.referee2.fl_str_mv |
Morgan-martins, Maria Isabel |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/0372820116852027 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/4711764363187583 |
dc.contributor.author.fl_str_mv |
Gressler, Camila Costa |
contributor_str_mv |
Hecktheuer, Luisa Helena Rychecki Callegaro, Maria da Graça Kolinski Morgan-martins, Maria Isabel |
dc.subject.por.fl_str_mv |
Ácidos graxos Citocinas Óleo coco Óleo abacate Óleo chia Perfil lipídico Mormofetria de fígado Ganho peso Consumo de dieta |
topic |
Ácidos graxos Citocinas Óleo coco Óleo abacate Óleo chia Perfil lipídico Mormofetria de fígado Ganho peso Consumo de dieta Fatty acids Cytokines Coconut oil Avocado oil Chia oil Lipid profile Morphometria of liver Weight gain Diet consumption CNPQ::CIENCIAS AGRARIAS::CIENCIA E TECNOLOGIA DE ALIMENTOS |
dc.subject.eng.fl_str_mv |
Fatty acids Cytokines Coconut oil Avocado oil Chia oil Lipid profile Morphometria of liver Weight gain Diet consumption |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS AGRARIAS::CIENCIA E TECNOLOGIA DE ALIMENTOS |
description |
The consumption of trans fat is strongly associated to the development of cardiovascular disease (CVD) by its action on plasma lipids and because they act in an inflammatory processes; besides, vegetable oils are used by population to prevent these kind of disease. The objective of this research was to determine the effect of consuming a high fat diet supplemented with coconut oil, avocado oil and chia oil in inflammatory and metabolic parameters in wistar rats. After seven days in adjustment period, 35 male Wistar rats received a standard diet for 45 days (TC), hyperlipidemic diet and coconut oil (DHCO), hyperlipidemic diet and avocado oil (DHAB) and hyperlipidemic diet and chia oil (DHCH), by gavage in the amount of 0.8 mL/kg body weight. The diet consumption and serum TG levels were higher in TC. Liver weight was higher in groups DHCO and DHAB, with no statistical difference between groups (p <0.05) considering weight gain, epididymal fat weight and TC, HDL and LDL serum levels. Higher plasma concentrations of IL-1, IL-6, TNF-α and IFN-γ were found in the groups DHSF, DHCO and DHAB and lower in TC and DHCH groups. The IL-10 was higher in the group DHCH. In the morphometric analysis, the DHCH group showed increase on the cell number and reduction on their cytoplasm area. The intervention on the hyperlipidemic diet consumption with trans fatty acid allowed to observe that the lipid profile is preceded by a systemic inflammatory environment, which is modulated by the omega-3 fatty acid (α-linolenic acid), present in chia oil, which reversed this scene, but does not override the consumption of a balanced diet observed by the TC group. This proves that dietary intervention to prevent CVD must be associated to appropriate choices of lipid intake, maintaining an adequate intake of omega-3, as evidenced in this paper by the decrease of pro-inflammatory cytokines (IL-1, IL -6, TNF-α and IFN-γ) and IL-10 increased, which is considered anti-inflammatory. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-05-29 |
dc.date.accessioned.fl_str_mv |
2017-03-06 |
dc.date.available.fl_str_mv |
2017-03-06 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
GRESSLER, Camila Costa. EFFECTS OF HYPERLIPIDEMIC DIET SUPLEMENTED WITH VEGETABLE OILS IN METABOLIC AND INFLAMMATORY PARAMETERS IN WISTAR RATS. 2013. 65 f. Dissertação (Mestrado em Ciência e Tecnologia dos Alimentos) - Universidade Federal de Santa Maria, Santa Maria, 2013. |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/5740 |
identifier_str_mv |
GRESSLER, Camila Costa. EFFECTS OF HYPERLIPIDEMIC DIET SUPLEMENTED WITH VEGETABLE OILS IN METABOLIC AND INFLAMMATORY PARAMETERS IN WISTAR RATS. 2013. 65 f. Dissertação (Mestrado em Ciência e Tecnologia dos Alimentos) - Universidade Federal de Santa Maria, Santa Maria, 2013. |
url |
http://repositorio.ufsm.br/handle/1/5740 |
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por |
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por |
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500700000006 |
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400 500 300 300 300 |
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Universidade Federal de Santa Maria |
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Programa de Pós-Graduação em Ciência e Tecnologia dos Alimentos |
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UFSM |
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BR |
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Ciência e Tecnologia dos Alimentos |
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Universidade Federal de Santa Maria |
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