Efeitos da dieta hiperlipídica suplementada com óleos vegetais nos parâmetros metabólicos e inflamatórios em ratos Wistar

• Autor(a) principal: Gressler, Camila Costa
• Data de Publicação: 2013
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional Manancial UFSM
• Texto Completo: http://repositorio.ufsm.br/handle/1/5740
• topic: Ácidos graxos; Citocinas; Óleo coco; Óleo abacate; Óleo chia; Perfil lipídico; Mormofetria de fígado; Ganho peso; Consumo de dieta; Fatty acids; Cytokines; Coconut oil; Avocado oil; Chia oil; Lipid profile; Morphometria of liver; Weight gain; Diet consumption; CNPQ::CIENCIAS AGRARIAS::CIENCIA E TECNOLOGIA DE ALIMENTOS

The consumption of trans fat is strongly associated to the development of cardiovascular disease (CVD) by its action on plasma lipids and because they act in an inflammatory processes; besides, vegetable oils are used by population to prevent these kind of disease. The objective of this research was to determine the effect of consuming a high fat diet supplemented with coconut oil, avocado oil and chia oil in inflammatory and metabolic parameters in wistar rats. After seven days in adjustment period, 35 male Wistar rats received a standard diet for 45 days (TC), hyperlipidemic diet and coconut oil (DHCO), hyperlipidemic diet and avocado oil (DHAB) and hyperlipidemic diet and chia oil (DHCH), by gavage in the amount of 0.8 mL/kg body weight. The diet consumption and serum TG levels were higher in TC. Liver weight was higher in groups DHCO and DHAB, with no statistical difference between groups (p <0.05) considering weight gain, epididymal fat weight and TC, HDL and LDL serum levels. Higher plasma concentrations of IL-1, IL-6, TNF-α and IFN-γ were found in the groups DHSF, DHCO and DHAB and lower in TC and DHCH groups. The IL-10 was higher in the group DHCH. In the morphometric analysis, the DHCH group showed increase on the cell number and reduction on their cytoplasm area. The intervention on the hyperlipidemic diet consumption with trans fatty acid allowed to observe that the lipid profile is preceded by a systemic inflammatory environment, which is modulated by the omega-3 fatty acid (α-linolenic acid), present in chia oil, which reversed this scene, but does not override the consumption of a balanced diet observed by the TC group. This proves that dietary intervention to prevent CVD must be associated to appropriate choices of lipid intake, maintaining an adequate intake of omega-3, as evidenced in this paper by the decrease of pro-inflammatory cytokines (IL-1, IL -6, TNF-α and IFN-γ) and IL-10 increased, which is considered anti-inflammatory.