Properties, bioactive potential and extraction processes of glycosaminoglycans: an overview

Detalhes bibliográficos
Autor(a) principal: Balbinot-Alfaro,Evellin
Data de Publicação: 2021
Outros Autores: Rocha,Meritaine da, Alfaro,Alexandre da Trindade, Martins,Vilásia Guimarães
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Ciência Rural
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000700402
Resumo: ABSTRACT: Glycosaminoglycans (GAGs) are long-chain polysaccharides that are divided into sulphates and non-sulphates, these being chondroitin sulphate, heparan sulphate, dermatan sulphate, heparin sulphate and the only non-sulphate in the group is hyaluronic acid. GAGs are obtained from animal tissue and by an expensive low-yield extraction process; however, they are highly commercially valued polysaccharides and exploited in the biomedical market. Their disaccharidic composition, chain length and sulfation pattern present great variability depending on the species and extraction factors. GAGs possess immunomodulatory, antioxidant, antiviral, anti-inflammatory, neuroprotective, antiproliferative and anticoagulant properties, functioning as therapeutic agents modulating an array of biological processes. This report presents the general aspects of each GAG, source and extraction process, in addition to the characteristics that give them the most varied therapeutic properties and pharmacological applications.
id UFSM-2_003784a18baa4151c8349f1187c43d02
oai_identifier_str oai:scielo:S0103-84782021000700402
network_acronym_str UFSM-2
network_name_str Ciência rural (Online)
repository_id_str
spelling Properties, bioactive potential and extraction processes of glycosaminoglycans: an overviewglycosaminoglycanspharmacological applicationsantiproliferativeanticoagulantABSTRACT: Glycosaminoglycans (GAGs) are long-chain polysaccharides that are divided into sulphates and non-sulphates, these being chondroitin sulphate, heparan sulphate, dermatan sulphate, heparin sulphate and the only non-sulphate in the group is hyaluronic acid. GAGs are obtained from animal tissue and by an expensive low-yield extraction process; however, they are highly commercially valued polysaccharides and exploited in the biomedical market. Their disaccharidic composition, chain length and sulfation pattern present great variability depending on the species and extraction factors. GAGs possess immunomodulatory, antioxidant, antiviral, anti-inflammatory, neuroprotective, antiproliferative and anticoagulant properties, functioning as therapeutic agents modulating an array of biological processes. This report presents the general aspects of each GAG, source and extraction process, in addition to the characteristics that give them the most varied therapeutic properties and pharmacological applications.Universidade Federal de Santa Maria2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000700402Ciência Rural v.51 n.7 2021reponame:Ciência Ruralinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM10.1590/0103-8478cr20200821info:eu-repo/semantics/openAccessBalbinot-Alfaro,EvellinRocha,Meritaine daAlfaro,Alexandre da TrindadeMartins,Vilásia Guimarãeseng2021-04-19T00:00:00ZRevista
dc.title.none.fl_str_mv Properties, bioactive potential and extraction processes of glycosaminoglycans: an overview
title Properties, bioactive potential and extraction processes of glycosaminoglycans: an overview
spellingShingle Properties, bioactive potential and extraction processes of glycosaminoglycans: an overview
Balbinot-Alfaro,Evellin
glycosaminoglycans
pharmacological applications
antiproliferative
anticoagulant
title_short Properties, bioactive potential and extraction processes of glycosaminoglycans: an overview
title_full Properties, bioactive potential and extraction processes of glycosaminoglycans: an overview
title_fullStr Properties, bioactive potential and extraction processes of glycosaminoglycans: an overview
title_full_unstemmed Properties, bioactive potential and extraction processes of glycosaminoglycans: an overview
title_sort Properties, bioactive potential and extraction processes of glycosaminoglycans: an overview
author Balbinot-Alfaro,Evellin
author_facet Balbinot-Alfaro,Evellin
Rocha,Meritaine da
Alfaro,Alexandre da Trindade
Martins,Vilásia Guimarães
author_role author
author2 Rocha,Meritaine da
Alfaro,Alexandre da Trindade
Martins,Vilásia Guimarães
author2_role author
author
author
dc.contributor.author.fl_str_mv Balbinot-Alfaro,Evellin
Rocha,Meritaine da
Alfaro,Alexandre da Trindade
Martins,Vilásia Guimarães
dc.subject.por.fl_str_mv glycosaminoglycans
pharmacological applications
antiproliferative
anticoagulant
topic glycosaminoglycans
pharmacological applications
antiproliferative
anticoagulant
description ABSTRACT: Glycosaminoglycans (GAGs) are long-chain polysaccharides that are divided into sulphates and non-sulphates, these being chondroitin sulphate, heparan sulphate, dermatan sulphate, heparin sulphate and the only non-sulphate in the group is hyaluronic acid. GAGs are obtained from animal tissue and by an expensive low-yield extraction process; however, they are highly commercially valued polysaccharides and exploited in the biomedical market. Their disaccharidic composition, chain length and sulfation pattern present great variability depending on the species and extraction factors. GAGs possess immunomodulatory, antioxidant, antiviral, anti-inflammatory, neuroprotective, antiproliferative and anticoagulant properties, functioning as therapeutic agents modulating an array of biological processes. This report presents the general aspects of each GAG, source and extraction process, in addition to the characteristics that give them the most varied therapeutic properties and pharmacological applications.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000700402
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000700402
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0103-8478cr20200821
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Universidade Federal de Santa Maria
publisher.none.fl_str_mv Universidade Federal de Santa Maria
dc.source.none.fl_str_mv Ciência Rural v.51 n.7 2021
reponame:Ciência Rural
instname:Universidade Federal de Santa Maria (UFSM)
instacron:UFSM
instname_str Universidade Federal de Santa Maria (UFSM)
instacron_str UFSM
institution UFSM
reponame_str Ciência Rural
collection Ciência Rural
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1749140556048498688

Registros relacionados