Unraveling the role of high-intensity resistance training on left ventricle proteome: Is there a shift towards maladaptation?

Detalhes bibliográficos
Autor(a) principal: Dantas, Patricia Sousa [UNIFESP]
Data de Publicação: 2016
Outros Autores: Sakata, Maisa Mayumi [UNIFESP], Perez, Juliana Dineia [UNIFESP], Watanabe, Regina Lucia Harumi [UNIFESP], Bizerra, Fernando Cesar [UNIFESP], Neves, Vander Jose das, Guzzoni, Vinicius, Marcondes, Fernanda Klein, Casarini, Dulce Elena [UNIFESP], Cunha, Tatiana Sousa [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: https://repositorio.unifesp.br/handle/11600/55979
http://dx.doi.org/10.1016/j.lfs.2016.03.040
Resumo: High-intensity resistance training (RT) induces adaptations that improve physiological function. However, high intensity, volume and/or frequency may lead to injury and other health issues such as adverse cardiac effects. The aim of this study was to evaluate the effect of RT on left ventricle proteome, and to identify the pathways involved on the harmful adaptations induced by this protocol. Male Wistar rats were randomized into 2 groups: Trained (T) and Sedentary (S). Animals from T group were trained for 6 weeks, and then all the animals were sacrificed and left ventricle was isolated for analysis. We identified 955 proteins, and 93 proteins were considered
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spelling Dantas, Patricia Sousa [UNIFESP]Sakata, Maisa Mayumi [UNIFESP]Perez, Juliana Dineia [UNIFESP]Watanabe, Regina Lucia Harumi [UNIFESP]Bizerra, Fernando Cesar [UNIFESP]Neves, Vander Jose dasGuzzoni, ViniciusMarcondes, Fernanda KleinCasarini, Dulce Elena [UNIFESP]Cunha, Tatiana Sousa [UNIFESP]2020-07-22T13:23:00Z2020-07-22T13:23:00Z2016Life Sciences. Oxford, v. 152, p. 156-164, 2016.0024-3205https://repositorio.unifesp.br/handle/11600/55979http://dx.doi.org/10.1016/j.lfs.2016.03.04010.1016/j.lfs.2016.03.040WOS:000375728500019High-intensity resistance training (RT) induces adaptations that improve physiological function. However, high intensity, volume and/or frequency may lead to injury and other health issues such as adverse cardiac effects. The aim of this study was to evaluate the effect of RT on left ventricle proteome, and to identify the pathways involved on the harmful adaptations induced by this protocol. Male Wistar rats were randomized into 2 groups: Trained (T) and Sedentary (S). Animals from T group were trained for 6 weeks, and then all the animals were sacrificed and left ventricle was isolated for analysis. We identified 955 proteins, and 93 proteins were considered36 were expressed exclusively in T group, and 4 in S group. Based on quantitative analysis, 42 proteins were found overexpressed and 11 underexpressed in T group compared with S group. Using the Gene Ontology to relate the biological processes in which these proteins are involved, we conclude that RT protocol promotes changes similar to those found in the initial phase of heart failure, but we also observed a concomitant increased expression of protective proteins, suggesting the activation of pathways to avoid major damages on left ventricle and delay the onset of pathological hypertrophy. Statement of significance of the study: Our study shows that high-intensity RT protocol changes left ventricle proteome, modifying metabolic profile of heart tissue and inducing the expression of proteins that acts against cardiac injury. We hypothesize that these adaptations occur to prevent the onset of cardiac dysfunction. Despite highly significant, it remains to be determined whether these adaptations are sufficient to further keep left ventricle function and exert cardioprotection, and whether this panel will be shifted towards maladaptation, and heart failure. (c) 2016 Elsevier Inc. All rights reserved.Fundacao de Amparo a Pesquisa do Estado de Sao Paulo-FAPESPFAEP/UNICAMPCAPES, BrazilFed Univ Sao Paulo UNIFESP, Dept Med, Discipline Nephrol, Sao Paulo, SP, BrazilFed Univ Sao Paulo UNIFESP, Dept Physiol, Discipline Nutr Physiol, Sao Paulo, SP, BrazilFed Univ Sao Paulo UNIFESP, Dept Med, Discipline Infect Dis, Special Mycol Lab LEMI, Sao Paulo, SP, BrazilUniv Estadual Campinas, Fac Dent Piracicaba FOP UNICAMP, Dept Physiol Sci, Piracicaba, SP, BrazilFed Univ Sao Paulo UNIFESP, Inst Sci & Technol, Dept Sci & Technol, BR-12231280 Sao Jose Dos Campos, SP, BrazilFed Univ Sao Paulo UNIFESP, Dept Med, Discipline Nephrol, Sao Paulo, SP, BrazilFed Univ Sao Paulo UNIFESP, Dept Physiol, Discipline Nutr Physiol, Sao Paulo, SP, BrazilFed Univ Sao Paulo UNIFESP, Dept Med, Discipline Infect Dis, Special Mycol Lab LEMI, Sao Paulo, SP, BrazilFed Univ Sao Paulo UNIFESP, Inst Sci & Technol, Dept Sci & Technol, BR-12231280 Sao Jose Dos Campos, SP, BrazilFAPESP: 02/05427-8FAEP/UNICAMP: 398/03FAEP/UNICAMP: 680/03Web of Science156-164engPergamon-Elsevier Science LtdLife SciencesProteomics shotgunRat proteomicsHigh-intensity resistance trainingCardiac hypertrophyPathological hypertrophyUnraveling the role of high-intensity resistance training on left ventricle proteome: Is there a shift towards maladaptation?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleOxford152info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/559792021-09-29 09:32:03.721metadata only accessoai:repositorio.unifesp.br:11600/55979Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:20:25.226935Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.en.fl_str_mv Unraveling the role of high-intensity resistance training on left ventricle proteome: Is there a shift towards maladaptation?
title Unraveling the role of high-intensity resistance training on left ventricle proteome: Is there a shift towards maladaptation?
spellingShingle Unraveling the role of high-intensity resistance training on left ventricle proteome: Is there a shift towards maladaptation?
Dantas, Patricia Sousa [UNIFESP]
Proteomics shotgun
Rat proteomics
High-intensity resistance training
Cardiac hypertrophy
Pathological hypertrophy
title_short Unraveling the role of high-intensity resistance training on left ventricle proteome: Is there a shift towards maladaptation?
title_full Unraveling the role of high-intensity resistance training on left ventricle proteome: Is there a shift towards maladaptation?
title_fullStr Unraveling the role of high-intensity resistance training on left ventricle proteome: Is there a shift towards maladaptation?
title_full_unstemmed Unraveling the role of high-intensity resistance training on left ventricle proteome: Is there a shift towards maladaptation?
title_sort Unraveling the role of high-intensity resistance training on left ventricle proteome: Is there a shift towards maladaptation?
author Dantas, Patricia Sousa [UNIFESP]
author_facet Dantas, Patricia Sousa [UNIFESP]
Sakata, Maisa Mayumi [UNIFESP]
Perez, Juliana Dineia [UNIFESP]
Watanabe, Regina Lucia Harumi [UNIFESP]
Bizerra, Fernando Cesar [UNIFESP]
Neves, Vander Jose das
Guzzoni, Vinicius
Marcondes, Fernanda Klein
Casarini, Dulce Elena [UNIFESP]
Cunha, Tatiana Sousa [UNIFESP]
author_role author
author2 Sakata, Maisa Mayumi [UNIFESP]
Perez, Juliana Dineia [UNIFESP]
Watanabe, Regina Lucia Harumi [UNIFESP]
Bizerra, Fernando Cesar [UNIFESP]
Neves, Vander Jose das
Guzzoni, Vinicius
Marcondes, Fernanda Klein
Casarini, Dulce Elena [UNIFESP]
Cunha, Tatiana Sousa [UNIFESP]
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Dantas, Patricia Sousa [UNIFESP]
Sakata, Maisa Mayumi [UNIFESP]
Perez, Juliana Dineia [UNIFESP]
Watanabe, Regina Lucia Harumi [UNIFESP]
Bizerra, Fernando Cesar [UNIFESP]
Neves, Vander Jose das
Guzzoni, Vinicius
Marcondes, Fernanda Klein
Casarini, Dulce Elena [UNIFESP]
Cunha, Tatiana Sousa [UNIFESP]
dc.subject.eng.fl_str_mv Proteomics shotgun
Rat proteomics
High-intensity resistance training
Cardiac hypertrophy
Pathological hypertrophy
topic Proteomics shotgun
Rat proteomics
High-intensity resistance training
Cardiac hypertrophy
Pathological hypertrophy
description High-intensity resistance training (RT) induces adaptations that improve physiological function. However, high intensity, volume and/or frequency may lead to injury and other health issues such as adverse cardiac effects. The aim of this study was to evaluate the effect of RT on left ventricle proteome, and to identify the pathways involved on the harmful adaptations induced by this protocol. Male Wistar rats were randomized into 2 groups: Trained (T) and Sedentary (S). Animals from T group were trained for 6 weeks, and then all the animals were sacrificed and left ventricle was isolated for analysis. We identified 955 proteins, and 93 proteins were considered
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2020-07-22T13:23:00Z
dc.date.available.fl_str_mv 2020-07-22T13:23:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Life Sciences. Oxford, v. 152, p. 156-164, 2016.
dc.identifier.uri.fl_str_mv https://repositorio.unifesp.br/handle/11600/55979
http://dx.doi.org/10.1016/j.lfs.2016.03.040
dc.identifier.issn.none.fl_str_mv 0024-3205
dc.identifier.doi.none.fl_str_mv 10.1016/j.lfs.2016.03.040
dc.identifier.wos.none.fl_str_mv WOS:000375728500019
identifier_str_mv Life Sciences. Oxford, v. 152, p. 156-164, 2016.
0024-3205
10.1016/j.lfs.2016.03.040
WOS:000375728500019
url https://repositorio.unifesp.br/handle/11600/55979
http://dx.doi.org/10.1016/j.lfs.2016.03.040
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv Life Sciences
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 156-164
dc.coverage.none.fl_str_mv Oxford
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv
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