Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthood
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/8453 https://dx.doi.org/10.3922/j.psns.2014.02.03 |
Resumo: | The present study evaluated the effects of postnatal intermittent hypoxia on locomotor activity and neuronal cell survival in early adulthood rats. During a critical period of brain development on postnatal day (PD) 7-11, male rat pups were exposed to intermittent hypoxia and randomly assigned to three experimental groups: (1) intermittent hypoxia, (2) normoxia, and (3) control (unhandled). One and a half months later on PD56, a behavioral test was conducted, and cell survival was estimated in the hilus, dental gyrus, and CA1 and CA3 subfields of the hippocampus, nucleus accumbens shell and core, dorsal and ventral striatum, and prefrontal cortex. Our results showed that intermittent hypoxia produced hyperactivity that correlated well with psychomotor agitation observed in patients with schizophrenia. Moreover, post-hypoxic rats exhibited a reduction of the number of neurons in the hilar region of the hippocampus and dorsal striatum, structures that have been neuropathologically associated with schizophrenia.These findings suggest that intermittent hypoxia can modify the pattern of locomotor activity and selectively affect neurons in rats tested in early adulthood. |
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Yamada, Karen Yukie [UNIFESP]Satake, Susan [UNIFESP]Perry, Juliana Cini [UNIFESP]Garcia, Karina de Oliveira [UNIFESP]D'Almeida, Vânia [UNIFESP]Tufik, Sergio [UNIFESP]Longo, Beatriz Monteiro [UNIFESP]Silva, Regina Cláudia Barbosa da [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2015-06-14T13:47:10Z2015-06-14T13:47:10Z2014-06-01Psychology & Neuroscience. Pontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São Paulo, v. 7, n. 2, p. 125-130, 2014.1983-3288https://repositorio.unifesp.br/handle/11600/8453https://dx.doi.org/10.3922/j.psns.2014.02.03S1983-32882014000200008.pdfS1983-3288201400020000810.3922/j.psns.2014.02.03The present study evaluated the effects of postnatal intermittent hypoxia on locomotor activity and neuronal cell survival in early adulthood rats. During a critical period of brain development on postnatal day (PD) 7-11, male rat pups were exposed to intermittent hypoxia and randomly assigned to three experimental groups: (1) intermittent hypoxia, (2) normoxia, and (3) control (unhandled). One and a half months later on PD56, a behavioral test was conducted, and cell survival was estimated in the hilus, dental gyrus, and CA1 and CA3 subfields of the hippocampus, nucleus accumbens shell and core, dorsal and ventral striatum, and prefrontal cortex. Our results showed that intermittent hypoxia produced hyperactivity that correlated well with psychomotor agitation observed in patients with schizophrenia. Moreover, post-hypoxic rats exhibited a reduction of the number of neurons in the hilar region of the hippocampus and dorsal striatum, structures that have been neuropathologically associated with schizophrenia.These findings suggest that intermittent hypoxia can modify the pattern of locomotor activity and selectively affect neurons in rats tested in early adulthood.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal de São Paulo (UNIFESP)UNIFESPFAPESP: 2006/61223-3FAPESP: 2009/07278-9FAPESP: 2009/07347-0FAPESP: 2009/03616-7FAPESP: 2010/00120-8CEPID: 98/14303-3SciELO125-130engPontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São PauloPsychology & NeuroscienceHypoxiaNeurodevelopmentHyperactivityCell survivalSchizophreniaEffect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthoodinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS1983-32882014000200008.pdfapplication/pdf1420081${dspace.ui.url}/bitstream/11600/8453/1/S1983-32882014000200008.pdfa238af4fd734d6bcf1a0fb96acf22c5dMD51open accessTEXTS1983-32882014000200008.pdf.txtS1983-32882014000200008.pdf.txtExtracted texttext/plain28097${dspace.ui.url}/bitstream/11600/8453/6/S1983-32882014000200008.pdf.txt9a3142f2c68c8d5e6af2b68a9551bfb4MD56open accessTHUMBNAILS1983-32882014000200008.pdf.jpgS1983-32882014000200008.pdf.jpgIM Thumbnailimage/jpeg7154${dspace.ui.url}/bitstream/11600/8453/8/S1983-32882014000200008.pdf.jpgfde455cdf5d8e2ddf6bc37d16fc761b2MD58open access11600/84532023-06-05 19:14:10.284open accessoai:repositorio.unifesp.br:11600/8453Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:14:10Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthood |
title |
Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthood |
spellingShingle |
Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthood Yamada, Karen Yukie [UNIFESP] Hypoxia Neurodevelopment Hyperactivity Cell survival Schizophrenia |
title_short |
Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthood |
title_full |
Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthood |
title_fullStr |
Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthood |
title_full_unstemmed |
Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthood |
title_sort |
Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthood |
author |
Yamada, Karen Yukie [UNIFESP] |
author_facet |
Yamada, Karen Yukie [UNIFESP] Satake, Susan [UNIFESP] Perry, Juliana Cini [UNIFESP] Garcia, Karina de Oliveira [UNIFESP] D'Almeida, Vânia [UNIFESP] Tufik, Sergio [UNIFESP] Longo, Beatriz Monteiro [UNIFESP] Silva, Regina Cláudia Barbosa da [UNIFESP] |
author_role |
author |
author2 |
Satake, Susan [UNIFESP] Perry, Juliana Cini [UNIFESP] Garcia, Karina de Oliveira [UNIFESP] D'Almeida, Vânia [UNIFESP] Tufik, Sergio [UNIFESP] Longo, Beatriz Monteiro [UNIFESP] Silva, Regina Cláudia Barbosa da [UNIFESP] |
author2_role |
author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Yamada, Karen Yukie [UNIFESP] Satake, Susan [UNIFESP] Perry, Juliana Cini [UNIFESP] Garcia, Karina de Oliveira [UNIFESP] D'Almeida, Vânia [UNIFESP] Tufik, Sergio [UNIFESP] Longo, Beatriz Monteiro [UNIFESP] Silva, Regina Cláudia Barbosa da [UNIFESP] |
dc.subject.eng.fl_str_mv |
Hypoxia Neurodevelopment Hyperactivity Cell survival Schizophrenia |
topic |
Hypoxia Neurodevelopment Hyperactivity Cell survival Schizophrenia |
description |
The present study evaluated the effects of postnatal intermittent hypoxia on locomotor activity and neuronal cell survival in early adulthood rats. During a critical period of brain development on postnatal day (PD) 7-11, male rat pups were exposed to intermittent hypoxia and randomly assigned to three experimental groups: (1) intermittent hypoxia, (2) normoxia, and (3) control (unhandled). One and a half months later on PD56, a behavioral test was conducted, and cell survival was estimated in the hilus, dental gyrus, and CA1 and CA3 subfields of the hippocampus, nucleus accumbens shell and core, dorsal and ventral striatum, and prefrontal cortex. Our results showed that intermittent hypoxia produced hyperactivity that correlated well with psychomotor agitation observed in patients with schizophrenia. Moreover, post-hypoxic rats exhibited a reduction of the number of neurons in the hilar region of the hippocampus and dorsal striatum, structures that have been neuropathologically associated with schizophrenia.These findings suggest that intermittent hypoxia can modify the pattern of locomotor activity and selectively affect neurons in rats tested in early adulthood. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-06-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:47:10Z |
dc.date.available.fl_str_mv |
2015-06-14T13:47:10Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Psychology & Neuroscience. Pontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São Paulo, v. 7, n. 2, p. 125-130, 2014. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/8453 https://dx.doi.org/10.3922/j.psns.2014.02.03 |
dc.identifier.issn.none.fl_str_mv |
1983-3288 |
dc.identifier.file.none.fl_str_mv |
S1983-32882014000200008.pdf |
dc.identifier.scielo.none.fl_str_mv |
S1983-32882014000200008 |
dc.identifier.doi.none.fl_str_mv |
10.3922/j.psns.2014.02.03 |
identifier_str_mv |
Psychology & Neuroscience. Pontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São Paulo, v. 7, n. 2, p. 125-130, 2014. 1983-3288 S1983-32882014000200008.pdf S1983-32882014000200008 10.3922/j.psns.2014.02.03 |
url |
https://repositorio.unifesp.br/handle/11600/8453 https://dx.doi.org/10.3922/j.psns.2014.02.03 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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Psychology & Neuroscience |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.format.none.fl_str_mv |
125-130 |
dc.publisher.none.fl_str_mv |
Pontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São Paulo |
publisher.none.fl_str_mv |
Pontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São Paulo |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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