Low-dose oral isotretinoin versus topical retinoic acid for photoaging: a randomized, comparative study

Detalhes bibliográficos
Autor(a) principal: Bagatin, Edileia [UNIFESP]
Data de Publicação: 2014
Outros Autores: Guadanhim, Lilia R. S. [UNIFESP], Enokihara, Milvia M. S. S. [UNIFESP], Sanudo, Adriana [UNIFESP], Talarico, Sergio [UNIFESP], Miot, Helio A. [UNIFESP], Gibson, Lawrence [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1111/ijd.12191
http://repositorio.unifesp.br/handle/11600/37123
Resumo: BackgroundOral isotretinoin (ISO) is the only drug which promotes prolonged remission or cure of severe acne. It also has other properties, supporting its use for non-acne indications. Retinoic acid (RA) is gold standard treatment for photoaging. ISO for photoaging treatment was reported in non-controlled trials as alternative to RA, which causes skin irritation.ObjectiveTo compare clinical, histological, and immunohistochemical effects of low-dose ISO and 0.05% topical RA to treat photoaging.MethodsRandomized, comparative, evaluator-blinded, single-center study. Twenty-four healthy, Caucasian, 50 to 75-year-old men and women (menopausal or sterilized) with advanced photoaging were included. Twelve subjects received ISO, 20 mg/day, and 12 subjects were treated with RA cream, for six months; both treatments were administered every other day, and moisturizer and sunscreen were also used. Outcome measures included patient assessments, blinded photographic evaluations, Life Quality Index, histological (HE, Verhoeff) and immunohistochemical (p53, collagen type I) evaluations, adverse events, liver function, lipid profile, and blood count. Statistical analysis with generalized estimating equations and repeated measures ANOVA tests was used.ResultsEleven subjects in each group completed the study. Patient and photographic assessments showed overall improvement in skin appearance. Quality-of-life scores were reduced for all subjects. Histological analysis revealed corneal layer diminution, epidermal thickness increase, and elastosis reduction. Immunohistochemical findings revealed significant epidermal p53 reduction and dermal collagen 1 increase. No differences were found between groups; laboratory tests showed no significant alterations.ConclusionDespite being safe and effective, low-dose ISO was not superior to 0.05% RA for advanced photoaging treatment.
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spelling Low-dose oral isotretinoin versus topical retinoic acid for photoaging: a randomized, comparative studyBackgroundOral isotretinoin (ISO) is the only drug which promotes prolonged remission or cure of severe acne. It also has other properties, supporting its use for non-acne indications. Retinoic acid (RA) is gold standard treatment for photoaging. ISO for photoaging treatment was reported in non-controlled trials as alternative to RA, which causes skin irritation.ObjectiveTo compare clinical, histological, and immunohistochemical effects of low-dose ISO and 0.05% topical RA to treat photoaging.MethodsRandomized, comparative, evaluator-blinded, single-center study. Twenty-four healthy, Caucasian, 50 to 75-year-old men and women (menopausal or sterilized) with advanced photoaging were included. Twelve subjects received ISO, 20 mg/day, and 12 subjects were treated with RA cream, for six months; both treatments were administered every other day, and moisturizer and sunscreen were also used. Outcome measures included patient assessments, blinded photographic evaluations, Life Quality Index, histological (HE, Verhoeff) and immunohistochemical (p53, collagen type I) evaluations, adverse events, liver function, lipid profile, and blood count. Statistical analysis with generalized estimating equations and repeated measures ANOVA tests was used.ResultsEleven subjects in each group completed the study. Patient and photographic assessments showed overall improvement in skin appearance. Quality-of-life scores were reduced for all subjects. Histological analysis revealed corneal layer diminution, epidermal thickness increase, and elastosis reduction. Immunohistochemical findings revealed significant epidermal p53 reduction and dermal collagen 1 increase. No differences were found between groups; laboratory tests showed no significant alterations.ConclusionDespite being safe and effective, low-dose ISO was not superior to 0.05% RA for advanced photoaging treatment.Universidade Federal de São Paulo UNIFESP, Dept Dermatol, BR-18618000 Sn Botucatu, SP, BrazilUniversidade Federal de São Paulo UNIFESP, Dept Dermatol, BR-18618000 Sn Botucatu, SP, BrazilWeb of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)FAPESP: 2009/51271-9Wiley-BlackwellUniversidade Federal de São Paulo (UNIFESP)Bagatin, Edileia [UNIFESP]Guadanhim, Lilia R. S. [UNIFESP]Enokihara, Milvia M. S. S. [UNIFESP]Sanudo, Adriana [UNIFESP]Talarico, Sergio [UNIFESP]Miot, Helio A. [UNIFESP]Gibson, Lawrence [UNIFESP]2016-01-24T14:34:55Z2016-01-24T14:34:55Z2014-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion114-122http://dx.doi.org/10.1111/ijd.12191International Journal of Dermatology. Hoboken: Wiley-Blackwell, v. 53, n. 1, p. 114-122, 2014.10.1111/ijd.121910011-9059http://repositorio.unifesp.br/handle/11600/37123WOS:000328543600066engInternational Journal of Dermatologyinfo:eu-repo/semantics/openAccesshttp://olabout.wiley.com/WileyCDA/Section/id-406071.htmlreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2021-09-30T13:40:03Zoai:repositorio.unifesp.br/:11600/37123Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652021-09-30T13:40:03Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Low-dose oral isotretinoin versus topical retinoic acid for photoaging: a randomized, comparative study
title Low-dose oral isotretinoin versus topical retinoic acid for photoaging: a randomized, comparative study
spellingShingle Low-dose oral isotretinoin versus topical retinoic acid for photoaging: a randomized, comparative study
Bagatin, Edileia [UNIFESP]
title_short Low-dose oral isotretinoin versus topical retinoic acid for photoaging: a randomized, comparative study
title_full Low-dose oral isotretinoin versus topical retinoic acid for photoaging: a randomized, comparative study
title_fullStr Low-dose oral isotretinoin versus topical retinoic acid for photoaging: a randomized, comparative study
title_full_unstemmed Low-dose oral isotretinoin versus topical retinoic acid for photoaging: a randomized, comparative study
title_sort Low-dose oral isotretinoin versus topical retinoic acid for photoaging: a randomized, comparative study
author Bagatin, Edileia [UNIFESP]
author_facet Bagatin, Edileia [UNIFESP]
Guadanhim, Lilia R. S. [UNIFESP]
Enokihara, Milvia M. S. S. [UNIFESP]
Sanudo, Adriana [UNIFESP]
Talarico, Sergio [UNIFESP]
Miot, Helio A. [UNIFESP]
Gibson, Lawrence [UNIFESP]
author_role author
author2 Guadanhim, Lilia R. S. [UNIFESP]
Enokihara, Milvia M. S. S. [UNIFESP]
Sanudo, Adriana [UNIFESP]
Talarico, Sergio [UNIFESP]
Miot, Helio A. [UNIFESP]
Gibson, Lawrence [UNIFESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Bagatin, Edileia [UNIFESP]
Guadanhim, Lilia R. S. [UNIFESP]
Enokihara, Milvia M. S. S. [UNIFESP]
Sanudo, Adriana [UNIFESP]
Talarico, Sergio [UNIFESP]
Miot, Helio A. [UNIFESP]
Gibson, Lawrence [UNIFESP]
description BackgroundOral isotretinoin (ISO) is the only drug which promotes prolonged remission or cure of severe acne. It also has other properties, supporting its use for non-acne indications. Retinoic acid (RA) is gold standard treatment for photoaging. ISO for photoaging treatment was reported in non-controlled trials as alternative to RA, which causes skin irritation.ObjectiveTo compare clinical, histological, and immunohistochemical effects of low-dose ISO and 0.05% topical RA to treat photoaging.MethodsRandomized, comparative, evaluator-blinded, single-center study. Twenty-four healthy, Caucasian, 50 to 75-year-old men and women (menopausal or sterilized) with advanced photoaging were included. Twelve subjects received ISO, 20 mg/day, and 12 subjects were treated with RA cream, for six months; both treatments were administered every other day, and moisturizer and sunscreen were also used. Outcome measures included patient assessments, blinded photographic evaluations, Life Quality Index, histological (HE, Verhoeff) and immunohistochemical (p53, collagen type I) evaluations, adverse events, liver function, lipid profile, and blood count. Statistical analysis with generalized estimating equations and repeated measures ANOVA tests was used.ResultsEleven subjects in each group completed the study. Patient and photographic assessments showed overall improvement in skin appearance. Quality-of-life scores were reduced for all subjects. Histological analysis revealed corneal layer diminution, epidermal thickness increase, and elastosis reduction. Immunohistochemical findings revealed significant epidermal p53 reduction and dermal collagen 1 increase. No differences were found between groups; laboratory tests showed no significant alterations.ConclusionDespite being safe and effective, low-dose ISO was not superior to 0.05% RA for advanced photoaging treatment.
publishDate 2014
dc.date.none.fl_str_mv 2014-01-01
2016-01-24T14:34:55Z
2016-01-24T14:34:55Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1111/ijd.12191
International Journal of Dermatology. Hoboken: Wiley-Blackwell, v. 53, n. 1, p. 114-122, 2014.
10.1111/ijd.12191
0011-9059
http://repositorio.unifesp.br/handle/11600/37123
WOS:000328543600066
url http://dx.doi.org/10.1111/ijd.12191
http://repositorio.unifesp.br/handle/11600/37123
identifier_str_mv International Journal of Dermatology. Hoboken: Wiley-Blackwell, v. 53, n. 1, p. 114-122, 2014.
10.1111/ijd.12191
0011-9059
WOS:000328543600066
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv International Journal of Dermatology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
http://olabout.wiley.com/WileyCDA/Section/id-406071.html
eu_rights_str_mv openAccess
rights_invalid_str_mv http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.format.none.fl_str_mv 114-122
dc.publisher.none.fl_str_mv Wiley-Blackwell
publisher.none.fl_str_mv Wiley-Blackwell
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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