Low-dose oral isotretinoin versus topical retinoic acid for photoaging: a randomized, comparative study
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1111/ijd.12191 http://repositorio.unifesp.br/handle/11600/37123 |
Resumo: | BackgroundOral isotretinoin (ISO) is the only drug which promotes prolonged remission or cure of severe acne. It also has other properties, supporting its use for non-acne indications. Retinoic acid (RA) is gold standard treatment for photoaging. ISO for photoaging treatment was reported in non-controlled trials as alternative to RA, which causes skin irritation.ObjectiveTo compare clinical, histological, and immunohistochemical effects of low-dose ISO and 0.05% topical RA to treat photoaging.MethodsRandomized, comparative, evaluator-blinded, single-center study. Twenty-four healthy, Caucasian, 50 to 75-year-old men and women (menopausal or sterilized) with advanced photoaging were included. Twelve subjects received ISO, 20 mg/day, and 12 subjects were treated with RA cream, for six months; both treatments were administered every other day, and moisturizer and sunscreen were also used. Outcome measures included patient assessments, blinded photographic evaluations, Life Quality Index, histological (HE, Verhoeff) and immunohistochemical (p53, collagen type I) evaluations, adverse events, liver function, lipid profile, and blood count. Statistical analysis with generalized estimating equations and repeated measures ANOVA tests was used.ResultsEleven subjects in each group completed the study. Patient and photographic assessments showed overall improvement in skin appearance. Quality-of-life scores were reduced for all subjects. Histological analysis revealed corneal layer diminution, epidermal thickness increase, and elastosis reduction. Immunohistochemical findings revealed significant epidermal p53 reduction and dermal collagen 1 increase. No differences were found between groups; laboratory tests showed no significant alterations.ConclusionDespite being safe and effective, low-dose ISO was not superior to 0.05% RA for advanced photoaging treatment. |
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Low-dose oral isotretinoin versus topical retinoic acid for photoaging: a randomized, comparative studyBackgroundOral isotretinoin (ISO) is the only drug which promotes prolonged remission or cure of severe acne. It also has other properties, supporting its use for non-acne indications. Retinoic acid (RA) is gold standard treatment for photoaging. ISO for photoaging treatment was reported in non-controlled trials as alternative to RA, which causes skin irritation.ObjectiveTo compare clinical, histological, and immunohistochemical effects of low-dose ISO and 0.05% topical RA to treat photoaging.MethodsRandomized, comparative, evaluator-blinded, single-center study. Twenty-four healthy, Caucasian, 50 to 75-year-old men and women (menopausal or sterilized) with advanced photoaging were included. Twelve subjects received ISO, 20 mg/day, and 12 subjects were treated with RA cream, for six months; both treatments were administered every other day, and moisturizer and sunscreen were also used. Outcome measures included patient assessments, blinded photographic evaluations, Life Quality Index, histological (HE, Verhoeff) and immunohistochemical (p53, collagen type I) evaluations, adverse events, liver function, lipid profile, and blood count. Statistical analysis with generalized estimating equations and repeated measures ANOVA tests was used.ResultsEleven subjects in each group completed the study. Patient and photographic assessments showed overall improvement in skin appearance. Quality-of-life scores were reduced for all subjects. Histological analysis revealed corneal layer diminution, epidermal thickness increase, and elastosis reduction. Immunohistochemical findings revealed significant epidermal p53 reduction and dermal collagen 1 increase. No differences were found between groups; laboratory tests showed no significant alterations.ConclusionDespite being safe and effective, low-dose ISO was not superior to 0.05% RA for advanced photoaging treatment.Universidade Federal de São Paulo UNIFESP, Dept Dermatol, BR-18618000 Sn Botucatu, SP, BrazilUniversidade Federal de São Paulo UNIFESP, Dept Dermatol, BR-18618000 Sn Botucatu, SP, BrazilWeb of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)FAPESP: 2009/51271-9Wiley-BlackwellUniversidade Federal de São Paulo (UNIFESP)Bagatin, Edileia [UNIFESP]Guadanhim, Lilia R. S. [UNIFESP]Enokihara, Milvia M. S. S. [UNIFESP]Sanudo, Adriana [UNIFESP]Talarico, Sergio [UNIFESP]Miot, Helio A. [UNIFESP]Gibson, Lawrence [UNIFESP]2016-01-24T14:34:55Z2016-01-24T14:34:55Z2014-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion114-122http://dx.doi.org/10.1111/ijd.12191International Journal of Dermatology. Hoboken: Wiley-Blackwell, v. 53, n. 1, p. 114-122, 2014.10.1111/ijd.121910011-9059http://repositorio.unifesp.br/handle/11600/37123WOS:000328543600066engInternational Journal of Dermatologyinfo:eu-repo/semantics/openAccesshttp://olabout.wiley.com/WileyCDA/Section/id-406071.htmlreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2021-09-30T13:40:03Zoai:repositorio.unifesp.br/:11600/37123Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652021-09-30T13:40:03Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Low-dose oral isotretinoin versus topical retinoic acid for photoaging: a randomized, comparative study |
title |
Low-dose oral isotretinoin versus topical retinoic acid for photoaging: a randomized, comparative study |
spellingShingle |
Low-dose oral isotretinoin versus topical retinoic acid for photoaging: a randomized, comparative study Bagatin, Edileia [UNIFESP] |
title_short |
Low-dose oral isotretinoin versus topical retinoic acid for photoaging: a randomized, comparative study |
title_full |
Low-dose oral isotretinoin versus topical retinoic acid for photoaging: a randomized, comparative study |
title_fullStr |
Low-dose oral isotretinoin versus topical retinoic acid for photoaging: a randomized, comparative study |
title_full_unstemmed |
Low-dose oral isotretinoin versus topical retinoic acid for photoaging: a randomized, comparative study |
title_sort |
Low-dose oral isotretinoin versus topical retinoic acid for photoaging: a randomized, comparative study |
author |
Bagatin, Edileia [UNIFESP] |
author_facet |
Bagatin, Edileia [UNIFESP] Guadanhim, Lilia R. S. [UNIFESP] Enokihara, Milvia M. S. S. [UNIFESP] Sanudo, Adriana [UNIFESP] Talarico, Sergio [UNIFESP] Miot, Helio A. [UNIFESP] Gibson, Lawrence [UNIFESP] |
author_role |
author |
author2 |
Guadanhim, Lilia R. S. [UNIFESP] Enokihara, Milvia M. S. S. [UNIFESP] Sanudo, Adriana [UNIFESP] Talarico, Sergio [UNIFESP] Miot, Helio A. [UNIFESP] Gibson, Lawrence [UNIFESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Bagatin, Edileia [UNIFESP] Guadanhim, Lilia R. S. [UNIFESP] Enokihara, Milvia M. S. S. [UNIFESP] Sanudo, Adriana [UNIFESP] Talarico, Sergio [UNIFESP] Miot, Helio A. [UNIFESP] Gibson, Lawrence [UNIFESP] |
description |
BackgroundOral isotretinoin (ISO) is the only drug which promotes prolonged remission or cure of severe acne. It also has other properties, supporting its use for non-acne indications. Retinoic acid (RA) is gold standard treatment for photoaging. ISO for photoaging treatment was reported in non-controlled trials as alternative to RA, which causes skin irritation.ObjectiveTo compare clinical, histological, and immunohistochemical effects of low-dose ISO and 0.05% topical RA to treat photoaging.MethodsRandomized, comparative, evaluator-blinded, single-center study. Twenty-four healthy, Caucasian, 50 to 75-year-old men and women (menopausal or sterilized) with advanced photoaging were included. Twelve subjects received ISO, 20 mg/day, and 12 subjects were treated with RA cream, for six months; both treatments were administered every other day, and moisturizer and sunscreen were also used. Outcome measures included patient assessments, blinded photographic evaluations, Life Quality Index, histological (HE, Verhoeff) and immunohistochemical (p53, collagen type I) evaluations, adverse events, liver function, lipid profile, and blood count. Statistical analysis with generalized estimating equations and repeated measures ANOVA tests was used.ResultsEleven subjects in each group completed the study. Patient and photographic assessments showed overall improvement in skin appearance. Quality-of-life scores were reduced for all subjects. Histological analysis revealed corneal layer diminution, epidermal thickness increase, and elastosis reduction. Immunohistochemical findings revealed significant epidermal p53 reduction and dermal collagen 1 increase. No differences were found between groups; laboratory tests showed no significant alterations.ConclusionDespite being safe and effective, low-dose ISO was not superior to 0.05% RA for advanced photoaging treatment. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-01-01 2016-01-24T14:34:55Z 2016-01-24T14:34:55Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1111/ijd.12191 International Journal of Dermatology. Hoboken: Wiley-Blackwell, v. 53, n. 1, p. 114-122, 2014. 10.1111/ijd.12191 0011-9059 http://repositorio.unifesp.br/handle/11600/37123 WOS:000328543600066 |
url |
http://dx.doi.org/10.1111/ijd.12191 http://repositorio.unifesp.br/handle/11600/37123 |
identifier_str_mv |
International Journal of Dermatology. Hoboken: Wiley-Blackwell, v. 53, n. 1, p. 114-122, 2014. 10.1111/ijd.12191 0011-9059 WOS:000328543600066 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International Journal of Dermatology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess http://olabout.wiley.com/WileyCDA/Section/id-406071.html |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://olabout.wiley.com/WileyCDA/Section/id-406071.html |
dc.format.none.fl_str_mv |
114-122 |
dc.publisher.none.fl_str_mv |
Wiley-Blackwell |
publisher.none.fl_str_mv |
Wiley-Blackwell |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
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1814268290810249216 |