Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| Texto Completo: | http://dx.doi.org/10.1590/S0102-695X2011005000174 http://repositorio.unifesp.br/handle/11600/6753 |
Resumo: | Croton macrobothrys Baill, Euphorbiaceae, is a tree from the Atlantic Forest in Southern Brazil, used in traditional medicine and popularly known as dragon's blood and pau-sangue. Leaf n-hexane, dichloromethane and methanol extracts were analyzed by GC/MS and evaluated for their in vitro antiproliferative activity on cell lines 786-0 (kidney), HT-29 (colon), K562 (leukemia), NCI-ADR/RES (drug resistant ovary), NCI-H460 (lung), MCF-7 (mammary), PC-3 (prostate), OVCAR-3 (ovary), U251 (glioma) and UACC-62 (melanoma). The dicloromethane extract exhibited activity against all cell lines at the concentration 25 µg/mL, in particular on cell lines NCI-H460 (GI50 0.33 μg/mL) and K5662 (GI50 0.91 μg/mL). Relevant constituents in dichloromethane extract are the alkaloids corydine and salutaridine, as well as the diterpenes geranylgeraniol and crotonin-derived clerodanes. |
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Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrysalkaloidsantiproliferative activityditerpenesmedicinal plantsCroton macrobothrys Baill, Euphorbiaceae, is a tree from the Atlantic Forest in Southern Brazil, used in traditional medicine and popularly known as dragon's blood and pau-sangue. Leaf n-hexane, dichloromethane and methanol extracts were analyzed by GC/MS and evaluated for their in vitro antiproliferative activity on cell lines 786-0 (kidney), HT-29 (colon), K562 (leukemia), NCI-ADR/RES (drug resistant ovary), NCI-H460 (lung), MCF-7 (mammary), PC-3 (prostate), OVCAR-3 (ovary), U251 (glioma) and UACC-62 (melanoma). The dicloromethane extract exhibited activity against all cell lines at the concentration 25 µg/mL, in particular on cell lines NCI-H460 (GI50 0.33 μg/mL) and K5662 (GI50 0.91 μg/mL). Relevant constituents in dichloromethane extract are the alkaloids corydine and salutaridine, as well as the diterpenes geranylgeraniol and crotonin-derived clerodanes.Universidade de São Paulo Instituto de BiociênciasUniversidade Federal de São Paulo (UNIFESP) Departamento de PsicobiologiaUniversidade Estadual de Campinas Divisão de Farmacologia e ToxicologiaInstituto de Botânica Seção de Curadoria do HerbárioUNIFESP, Depto. de PsicobiologiaSciELOConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)FAPESP: 08/10595-3 auxilioFAPESP: 08/09942-0 bolsaSociedade Brasileira de FarmacognosiaUniversidade de São Paulo (USP)Universidade Federal de São Paulo (UNIFESP)Universidade Estadual de Campinas (UNICAMP)Instituto de Botânica Seção de Curadoria do HerbárioMotta, Lucimar Barbosa daFurlan, Cláudia MariaSantos, Deborah Yara Alves Cursino dosSalatino, Maria Luiza FariaDuarte-Almeida, Joaquim Mauricio [UNIFESP]Negri, Giuseppina [UNIFESP]Carvalho, João Ernesto de [UNIFESP]Ruiz, Ana Lúcia Tasca GoisCordeiro, InêsSalatino, Antonio2015-06-14T13:43:24Z2015-06-14T13:43:24Z2011-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion972-977application/pdfhttp://dx.doi.org/10.1590/S0102-695X2011005000174Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 21, n. 6, p. 972-977, 2011.10.1590/S0102-695X2011005000174S0102-695X2011000600006.pdf0102-695XS0102-695X2011000600006http://repositorio.unifesp.br/handle/11600/6753WOS:000297216900006engRevista Brasileira de Farmacognosiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-06T00:59:07Zoai:repositorio.unifesp.br/:11600/6753Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-06T00:59:07Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys |
| title |
Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys |
| spellingShingle |
Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys Motta, Lucimar Barbosa da alkaloids antiproliferative activity diterpenes medicinal plants |
| title_short |
Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys |
| title_full |
Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys |
| title_fullStr |
Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys |
| title_full_unstemmed |
Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys |
| title_sort |
Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys |
| author |
Motta, Lucimar Barbosa da |
| author_facet |
Motta, Lucimar Barbosa da Furlan, Cláudia Maria Santos, Deborah Yara Alves Cursino dos Salatino, Maria Luiza Faria Duarte-Almeida, Joaquim Mauricio [UNIFESP] Negri, Giuseppina [UNIFESP] Carvalho, João Ernesto de [UNIFESP] Ruiz, Ana Lúcia Tasca Gois Cordeiro, Inês Salatino, Antonio |
| author_role |
author |
| author2 |
Furlan, Cláudia Maria Santos, Deborah Yara Alves Cursino dos Salatino, Maria Luiza Faria Duarte-Almeida, Joaquim Mauricio [UNIFESP] Negri, Giuseppina [UNIFESP] Carvalho, João Ernesto de [UNIFESP] Ruiz, Ana Lúcia Tasca Gois Cordeiro, Inês Salatino, Antonio |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Federal de São Paulo (UNIFESP) Universidade Estadual de Campinas (UNICAMP) Instituto de Botânica Seção de Curadoria do Herbário |
| dc.contributor.author.fl_str_mv |
Motta, Lucimar Barbosa da Furlan, Cláudia Maria Santos, Deborah Yara Alves Cursino dos Salatino, Maria Luiza Faria Duarte-Almeida, Joaquim Mauricio [UNIFESP] Negri, Giuseppina [UNIFESP] Carvalho, João Ernesto de [UNIFESP] Ruiz, Ana Lúcia Tasca Gois Cordeiro, Inês Salatino, Antonio |
| dc.subject.por.fl_str_mv |
alkaloids antiproliferative activity diterpenes medicinal plants |
| topic |
alkaloids antiproliferative activity diterpenes medicinal plants |
| description |
Croton macrobothrys Baill, Euphorbiaceae, is a tree from the Atlantic Forest in Southern Brazil, used in traditional medicine and popularly known as dragon's blood and pau-sangue. Leaf n-hexane, dichloromethane and methanol extracts were analyzed by GC/MS and evaluated for their in vitro antiproliferative activity on cell lines 786-0 (kidney), HT-29 (colon), K562 (leukemia), NCI-ADR/RES (drug resistant ovary), NCI-H460 (lung), MCF-7 (mammary), PC-3 (prostate), OVCAR-3 (ovary), U251 (glioma) and UACC-62 (melanoma). The dicloromethane extract exhibited activity against all cell lines at the concentration 25 µg/mL, in particular on cell lines NCI-H460 (GI50 0.33 μg/mL) and K5662 (GI50 0.91 μg/mL). Relevant constituents in dichloromethane extract are the alkaloids corydine and salutaridine, as well as the diterpenes geranylgeraniol and crotonin-derived clerodanes. |
| publishDate |
2011 |
| dc.date.none.fl_str_mv |
2011-12-01 2015-06-14T13:43:24Z 2015-06-14T13:43:24Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0102-695X2011005000174 Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 21, n. 6, p. 972-977, 2011. 10.1590/S0102-695X2011005000174 S0102-695X2011000600006.pdf 0102-695X S0102-695X2011000600006 http://repositorio.unifesp.br/handle/11600/6753 WOS:000297216900006 |
| url |
http://dx.doi.org/10.1590/S0102-695X2011005000174 http://repositorio.unifesp.br/handle/11600/6753 |
| identifier_str_mv |
Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 21, n. 6, p. 972-977, 2011. 10.1590/S0102-695X2011005000174 S0102-695X2011000600006.pdf 0102-695X S0102-695X2011000600006 WOS:000297216900006 |
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eng |
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eng |
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Revista Brasileira de Farmacognosia |
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info:eu-repo/semantics/openAccess |
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openAccess |
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972-977 application/pdf |
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Sociedade Brasileira de Farmacognosia |
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Sociedade Brasileira de Farmacognosia |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Universidade Federal de São Paulo (UNIFESP) |
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UNIFESP |
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UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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biblioteca.csp@unifesp.br |
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1814268291039887360 |