Activity of Debaryomyces hansenii UFV-1 a-galactosidases against a-D-galactopyranoside derivatives

• Main Author: Rezende, Sebastião T. de
• Publication Date: 2011
• Other Authors: Viana, Pollyanna A., Alves, Arianne de A., Manfrini, Rozângela M., Alves, Ricardo J., Bemquerer, Marcelo P., Santoro, Marcelo M., Guimarães, Valéria M.
• Format: Article
• Language: eng
• Source: LOCUS Repositório Institucional da UFV
• Download full: https://doi.org/10.1016/j.carres.2011.01.024; http://www.locus.ufv.br/handle/123456789/19851
• topic: α-Galactosidases; Debaryomyces hansenii UFV-1; α-d-Galactopyranoside derivatives; Inhibition

α-d-Galactopyranosides were synthesized and their inhibitory activities toward the Debaryomyces hansenii UFV-1 extracellular and intracellular α-galactosidases were evaluated. Methyl α-d-galactopyranoside was the most potent inhibitor compared to the others tested, with values of 0.82 and 1.12 mmol L−1, for extracellular and intracellular enzymes, respectively. These results indicate that the presence of a hydroxyl group in the C-6 position of α-d-galactopyranoside derivatives is important for the recognition by D. hansenii UFV-1 α-galactosidases.