Activity of Debaryomyces hansenii UFV-1 a-galactosidases against a-D-galactopyranoside derivatives

Detalhes bibliográficos
Autor(a) principal: Rezende, Sebastião T. de
Data de Publicação: 2011
Outros Autores: Viana, Pollyanna A., Alves, Arianne de A., Manfrini, Rozângela M., Alves, Ricardo J., Bemquerer, Marcelo P., Santoro, Marcelo M., Guimarães, Valéria M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: LOCUS Repositório Institucional da UFV
Texto Completo: https://doi.org/10.1016/j.carres.2011.01.024
http://www.locus.ufv.br/handle/123456789/19851
Resumo: α-d-Galactopyranosides were synthesized and their inhibitory activities toward the Debaryomyces hansenii UFV-1 extracellular and intracellular α-galactosidases were evaluated. Methyl α-d-galactopyranoside was the most potent inhibitor compared to the others tested, with values of 0.82 and 1.12 mmol L−1, for extracellular and intracellular enzymes, respectively. These results indicate that the presence of a hydroxyl group in the C-6 position of α-d-galactopyranoside derivatives is important for the recognition by D. hansenii UFV-1 α-galactosidases.
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spelling Rezende, Sebastião T. deViana, Pollyanna A.Alves, Arianne de A.Manfrini, Rozângela M.Alves, Ricardo J.Bemquerer, Marcelo P.Santoro, Marcelo M.Guimarães, Valéria M.2018-05-29T10:22:53Z2018-05-29T10:22:53Z2011-04-0100086215https://doi.org/10.1016/j.carres.2011.01.024http://www.locus.ufv.br/handle/123456789/19851α-d-Galactopyranosides were synthesized and their inhibitory activities toward the Debaryomyces hansenii UFV-1 extracellular and intracellular α-galactosidases were evaluated. Methyl α-d-galactopyranoside was the most potent inhibitor compared to the others tested, with values of 0.82 and 1.12 mmol L−1, for extracellular and intracellular enzymes, respectively. These results indicate that the presence of a hydroxyl group in the C-6 position of α-d-galactopyranoside derivatives is important for the recognition by D. hansenii UFV-1 α-galactosidases.engCarbohydrate Researchv. 346, n. 5, p. 602-605, Abril 2011Elsevier Ltd.info:eu-repo/semantics/openAccessα-GalactosidasesDebaryomyces hansenii UFV-1α-d-Galactopyranoside derivativesInhibitionActivity of Debaryomyces hansenii UFV-1 a-galactosidases against a-D-galactopyranoside derivativesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfreponame:LOCUS Repositório Institucional da UFVinstname:Universidade Federal de Viçosa (UFV)instacron:UFVORIGINALartigo.pdfartigo.pdftexto completoapplication/pdf244001https://locus.ufv.br//bitstream/123456789/19851/1/artigo.pdf1060769ee67301352b61955cbac3028aMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://locus.ufv.br//bitstream/123456789/19851/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAILartigo.pdf.jpgartigo.pdf.jpgIM Thumbnailimage/jpeg5227https://locus.ufv.br//bitstream/123456789/19851/3/artigo.pdf.jpg99d331f428f1a31b93b73d322fae3f33MD53123456789/198512018-05-29 23:00:35.89oai:locus.ufv.br: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Repositório InstitucionalPUBhttps://www.locus.ufv.br/oai/requestfabiojreis@ufv.bropendoar:21452018-05-30T02:00:35LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)false
dc.title.en.fl_str_mv Activity of Debaryomyces hansenii UFV-1 a-galactosidases against a-D-galactopyranoside derivatives
title Activity of Debaryomyces hansenii UFV-1 a-galactosidases against a-D-galactopyranoside derivatives
spellingShingle Activity of Debaryomyces hansenii UFV-1 a-galactosidases against a-D-galactopyranoside derivatives
Rezende, Sebastião T. de
α-Galactosidases
Debaryomyces hansenii UFV-1
α-d-Galactopyranoside derivatives
Inhibition
title_short Activity of Debaryomyces hansenii UFV-1 a-galactosidases against a-D-galactopyranoside derivatives
title_full Activity of Debaryomyces hansenii UFV-1 a-galactosidases against a-D-galactopyranoside derivatives
title_fullStr Activity of Debaryomyces hansenii UFV-1 a-galactosidases against a-D-galactopyranoside derivatives
title_full_unstemmed Activity of Debaryomyces hansenii UFV-1 a-galactosidases against a-D-galactopyranoside derivatives
title_sort Activity of Debaryomyces hansenii UFV-1 a-galactosidases against a-D-galactopyranoside derivatives
author Rezende, Sebastião T. de
author_facet Rezende, Sebastião T. de
Viana, Pollyanna A.
Alves, Arianne de A.
Manfrini, Rozângela M.
Alves, Ricardo J.
Bemquerer, Marcelo P.
Santoro, Marcelo M.
Guimarães, Valéria M.
author_role author
author2 Viana, Pollyanna A.
Alves, Arianne de A.
Manfrini, Rozângela M.
Alves, Ricardo J.
Bemquerer, Marcelo P.
Santoro, Marcelo M.
Guimarães, Valéria M.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rezende, Sebastião T. de
Viana, Pollyanna A.
Alves, Arianne de A.
Manfrini, Rozângela M.
Alves, Ricardo J.
Bemquerer, Marcelo P.
Santoro, Marcelo M.
Guimarães, Valéria M.
dc.subject.pt-BR.fl_str_mv α-Galactosidases
Debaryomyces hansenii UFV-1
α-d-Galactopyranoside derivatives
Inhibition
topic α-Galactosidases
Debaryomyces hansenii UFV-1
α-d-Galactopyranoside derivatives
Inhibition
description α-d-Galactopyranosides were synthesized and their inhibitory activities toward the Debaryomyces hansenii UFV-1 extracellular and intracellular α-galactosidases were evaluated. Methyl α-d-galactopyranoside was the most potent inhibitor compared to the others tested, with values of 0.82 and 1.12 mmol L−1, for extracellular and intracellular enzymes, respectively. These results indicate that the presence of a hydroxyl group in the C-6 position of α-d-galactopyranoside derivatives is important for the recognition by D. hansenii UFV-1 α-galactosidases.
publishDate 2011
dc.date.issued.fl_str_mv 2011-04-01
dc.date.accessioned.fl_str_mv 2018-05-29T10:22:53Z
dc.date.available.fl_str_mv 2018-05-29T10:22:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.1016/j.carres.2011.01.024
http://www.locus.ufv.br/handle/123456789/19851
dc.identifier.issn.none.fl_str_mv 00086215
identifier_str_mv 00086215
url https://doi.org/10.1016/j.carres.2011.01.024
http://www.locus.ufv.br/handle/123456789/19851
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartofseries.pt-BR.fl_str_mv v. 346, n. 5, p. 602-605, Abril 2011
dc.rights.driver.fl_str_mv Elsevier Ltd.
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Elsevier Ltd.
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Carbohydrate Research
publisher.none.fl_str_mv Carbohydrate Research
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