Zika virus serological diagnosis: commercial tests and monoclonal antibodies as tools
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | The Journal of venomous animals and toxins including tropical diseases (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992020000100208 |
Resumo: | Abstract Zika virus (ZIKV), an emerging arthropod-borne virus (arbovirus) of the Flaviviridae family, is a current issue worldwide, particularly because of the congenital and neurological syndromes associated with infection by this virus. As the initial clinical symptoms of all diseases caused by this group are very similar, clinical diagnosis is difficult. Furthermore, laboratory diagnostic efforts have failed to identify specific and accurate tests for each virus of the Flaviviridae family due to the cross-reactivity of these viruses in serum samples. This situation has resulted in underreporting of the diseases caused by flaviviruses. However, many companies developed commercial diagnostic tests after the recent ZIKV outbreak. Moreover, health regulatory agencies have approved different commercial tests to extend the monitoring of ZIKV infections. Considering that a specific and sensitive diagnostic method for estimating risk and evaluating ZIKV propagation is still needed, this review aims to provide an update of the main commercially approved serological diagnostics test by the US Food and Drug Administration (FDA) and Brazilian National Health Surveillance Agency (ANVISA). Additionally, we present the technologies used for monoclonal antibody production as a tool for the development of diagnostic tests and applications of these antibodies in detecting ZIKV infections worldwide. |
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The Journal of venomous animals and toxins including tropical diseases (Online) |
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Zika virus serological diagnosis: commercial tests and monoclonal antibodies as toolsZika virusFlavivirusesSerological diagnosisCommercial testsMonoclonal antibodyAbstract Zika virus (ZIKV), an emerging arthropod-borne virus (arbovirus) of the Flaviviridae family, is a current issue worldwide, particularly because of the congenital and neurological syndromes associated with infection by this virus. As the initial clinical symptoms of all diseases caused by this group are very similar, clinical diagnosis is difficult. Furthermore, laboratory diagnostic efforts have failed to identify specific and accurate tests for each virus of the Flaviviridae family due to the cross-reactivity of these viruses in serum samples. This situation has resulted in underreporting of the diseases caused by flaviviruses. However, many companies developed commercial diagnostic tests after the recent ZIKV outbreak. Moreover, health regulatory agencies have approved different commercial tests to extend the monitoring of ZIKV infections. Considering that a specific and sensitive diagnostic method for estimating risk and evaluating ZIKV propagation is still needed, this review aims to provide an update of the main commercially approved serological diagnostics test by the US Food and Drug Administration (FDA) and Brazilian National Health Surveillance Agency (ANVISA). Additionally, we present the technologies used for monoclonal antibody production as a tool for the development of diagnostic tests and applications of these antibodies in detecting ZIKV infections worldwide.Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992020000100208Journal of Venomous Animals and Toxins including Tropical Diseases v.26 2020reponame:The Journal of venomous animals and toxins including tropical diseases (Online)instname:Universidade Estadual Paulista (UNESP)instacron:UNESP10.1590/1678-9199-jvatitd-2020-0019info:eu-repo/semantics/openAccessSilva,Isaura Beatriz BorgesSilva,Aldacilene Souza daCunha,Mariana SequetinCabral,Aline DinizOliveira,Kelly Cristina Alves deGaspari,Elizabeth DePrudencio,Carlos Robertoeng2020-11-16T00:00:00Zoai:scielo:S1678-91992020000100208Revistahttp://www.scielo.br/jvatitdPUBhttps://old.scielo.br/oai/scielo-oai.php||editorial@jvat.org.br1678-91991678-9180opendoar:2020-11-16T00:00The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Zika virus serological diagnosis: commercial tests and monoclonal antibodies as tools |
title |
Zika virus serological diagnosis: commercial tests and monoclonal antibodies as tools |
spellingShingle |
Zika virus serological diagnosis: commercial tests and monoclonal antibodies as tools Silva,Isaura Beatriz Borges Zika virus Flaviviruses Serological diagnosis Commercial tests Monoclonal antibody |
title_short |
Zika virus serological diagnosis: commercial tests and monoclonal antibodies as tools |
title_full |
Zika virus serological diagnosis: commercial tests and monoclonal antibodies as tools |
title_fullStr |
Zika virus serological diagnosis: commercial tests and monoclonal antibodies as tools |
title_full_unstemmed |
Zika virus serological diagnosis: commercial tests and monoclonal antibodies as tools |
title_sort |
Zika virus serological diagnosis: commercial tests and monoclonal antibodies as tools |
author |
Silva,Isaura Beatriz Borges |
author_facet |
Silva,Isaura Beatriz Borges Silva,Aldacilene Souza da Cunha,Mariana Sequetin Cabral,Aline Diniz Oliveira,Kelly Cristina Alves de Gaspari,Elizabeth De Prudencio,Carlos Roberto |
author_role |
author |
author2 |
Silva,Aldacilene Souza da Cunha,Mariana Sequetin Cabral,Aline Diniz Oliveira,Kelly Cristina Alves de Gaspari,Elizabeth De Prudencio,Carlos Roberto |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Silva,Isaura Beatriz Borges Silva,Aldacilene Souza da Cunha,Mariana Sequetin Cabral,Aline Diniz Oliveira,Kelly Cristina Alves de Gaspari,Elizabeth De Prudencio,Carlos Roberto |
dc.subject.por.fl_str_mv |
Zika virus Flaviviruses Serological diagnosis Commercial tests Monoclonal antibody |
topic |
Zika virus Flaviviruses Serological diagnosis Commercial tests Monoclonal antibody |
description |
Abstract Zika virus (ZIKV), an emerging arthropod-borne virus (arbovirus) of the Flaviviridae family, is a current issue worldwide, particularly because of the congenital and neurological syndromes associated with infection by this virus. As the initial clinical symptoms of all diseases caused by this group are very similar, clinical diagnosis is difficult. Furthermore, laboratory diagnostic efforts have failed to identify specific and accurate tests for each virus of the Flaviviridae family due to the cross-reactivity of these viruses in serum samples. This situation has resulted in underreporting of the diseases caused by flaviviruses. However, many companies developed commercial diagnostic tests after the recent ZIKV outbreak. Moreover, health regulatory agencies have approved different commercial tests to extend the monitoring of ZIKV infections. Considering that a specific and sensitive diagnostic method for estimating risk and evaluating ZIKV propagation is still needed, this review aims to provide an update of the main commercially approved serological diagnostics test by the US Food and Drug Administration (FDA) and Brazilian National Health Surveillance Agency (ANVISA). Additionally, we present the technologies used for monoclonal antibody production as a tool for the development of diagnostic tests and applications of these antibodies in detecting ZIKV infections worldwide. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992020000100208 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992020000100208 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-9199-jvatitd-2020-0019 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) |
publisher.none.fl_str_mv |
Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) |
dc.source.none.fl_str_mv |
Journal of Venomous Animals and Toxins including Tropical Diseases v.26 2020 reponame:The Journal of venomous animals and toxins including tropical diseases (Online) instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
The Journal of venomous animals and toxins including tropical diseases (Online) |
collection |
The Journal of venomous animals and toxins including tropical diseases (Online) |
repository.name.fl_str_mv |
The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
||editorial@jvat.org.br |
_version_ |
1748958540617220096 |