Effect of anti-inflammators on seizures induced by pentylenetetrazole in the Kindling model: a review
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/21581 |
Resumo: | Introduction: Studies with steroidal and non-steroidal anti-inflammatory drugs in animal models have been carried out in order to verify new therapeutic approaches for the treatment of epilepsy to improve the quality of life of patients with this disease that affects about 65 million people worldwide. Objective: to analyze the relevance of these medications in the treatment of seizures. Methodology: this study is a literature review in order to assess the effects of anti-inflammatory drugs in seizures. Results: the results obtained demonstrate that the animals treated with the steroidal and non-steroidal anti-inflammatory drugs studied had a much lower intensity reduction in convulsive crises without progressing to the Racine 4 scale. Conclusion: It is concluded that the studied steroidal and non-steroidal anti-inflammatory drugs have a protective and reductive effect on inflammatory crises induced by pentilenotetrazol, decreasing the inflammatory cytokines in the central nervous system. |
id |
UNIFEI_29db396e566633c3acd38a484fb78ca8 |
---|---|
oai_identifier_str |
oai:ojs.pkp.sfu.ca:article/21581 |
network_acronym_str |
UNIFEI |
network_name_str |
Research, Society and Development |
repository_id_str |
|
spelling |
Effect of anti-inflammators on seizures induced by pentylenetetrazole in the Kindling model: a reviewEfecto de los antiinflamadores sobre las convulsiones inducidas por pentilenetetrazol en el modelo Kindling: una revisiónEfeito dos anti-inflamatorios nas convulsões induzidas por pentilenotetrazol no modelo de Kindling: uma revisãoEpilepsiaAntiinflamatorioModelos animales.EpilepsiaAnti-inflamatóriosModelos animais.EpilepsyAnti-inflammatory AgentsAnimal models.Introduction: Studies with steroidal and non-steroidal anti-inflammatory drugs in animal models have been carried out in order to verify new therapeutic approaches for the treatment of epilepsy to improve the quality of life of patients with this disease that affects about 65 million people worldwide. Objective: to analyze the relevance of these medications in the treatment of seizures. Methodology: this study is a literature review in order to assess the effects of anti-inflammatory drugs in seizures. Results: the results obtained demonstrate that the animals treated with the steroidal and non-steroidal anti-inflammatory drugs studied had a much lower intensity reduction in convulsive crises without progressing to the Racine 4 scale. Conclusion: It is concluded that the studied steroidal and non-steroidal anti-inflammatory drugs have a protective and reductive effect on inflammatory crises induced by pentilenotetrazol, decreasing the inflammatory cytokines in the central nervous system.Introducción: Se han realizado estudios con antiinflamatorios esteroideos y no esteroideos en modelos animales con el fin de verificar nuevos enfoques terapéuticos para el tratamiento de la epilepsia para mejorar la calidad de vida de los pacientes con esta enfermedad que afecta a cerca de 65 millones de personas en todo el mundo. Objetivo: analizar la relevancia de estos medicamentos en el tratamiento de las convulsiones. Metodología: este estudio es una revisión de la literatura con el fin de evaluar los efectos de los fármacos antiinflamatorios en las convulsiones. Resultados: los resultados obtenidos demuestran que los animales tratados con los antiinflamatorios esteroideos y no esteroideos estudiados presentaron una reducción de intensidad mucho menor en las crisis convulsivas sin progresar a la escala Racine 4. Conclusión: Se concluye que los antiinflamatorios esteroideos y no esteroideos estudiados tienen un efecto protector y reductor sobre las crisis inflamatorias inducidas por pentilotetrazol, disminuyendo las citocinas inflamatorias en el sistema nervioso central.Introdução: Estudos com anti-inflamatórios esteroidais e não esteroidais em modelo animal tem sido realizados a fim de verificar novas abordagens terapêuticas para o tratamento da epilepsia para melhorar a qualidade de vida dos pacientes portadores desta doença que acomete cerca de 65 milhões de pessoas no mundo. Objetivo: analisar a relevância no tratamento das crises convulsivas destes medicamentos. Metodologia: o presente estudo trata-se de uma revisão de literatura a fim de avaliar os efeitos dos anti-inflamatórios nas crises convulsivas. Resultado: os resultados obtidos demonstram que os animais tratados com os anti-inflamatórios esteroidais e não esteroidais estudados tiveram uma redução de intensidade nas crises convulsivas bem mais baixas sem evolução para a escala 4 de Racine. Conclusão: Conclui-se que os medicamentos anti-inflamatórios esteroidais e não esteroidais estudados tem o efeito protetivo e redutivo nas crises inflamatórias induzidas por pentilenotetrazol diminuindo as citocinas inflamatórias no sistema nervoso central. Research, Society and Development2021-10-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2158110.33448/rsd-v10i13.21581Research, Society and Development; Vol. 10 No. 13; e538101321581Research, Society and Development; Vol. 10 Núm. 13; e538101321581Research, Society and Development; v. 10 n. 13; e5381013215812525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/21581/19202Copyright (c) 2021 Nicole Magarefo Barco; Vagner Fagnani Linartevichihttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessBarco, Nicole MagarefoLinartevichi, Vagner Fagnani2021-11-21T18:26:28Zoai:ojs.pkp.sfu.ca:article/21581Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:40:58.409981Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Effect of anti-inflammators on seizures induced by pentylenetetrazole in the Kindling model: a review Efecto de los antiinflamadores sobre las convulsiones inducidas por pentilenetetrazol en el modelo Kindling: una revisión Efeito dos anti-inflamatorios nas convulsões induzidas por pentilenotetrazol no modelo de Kindling: uma revisão |
title |
Effect of anti-inflammators on seizures induced by pentylenetetrazole in the Kindling model: a review |
spellingShingle |
Effect of anti-inflammators on seizures induced by pentylenetetrazole in the Kindling model: a review Barco, Nicole Magarefo Epilepsia Antiinflamatorio Modelos animales. Epilepsia Anti-inflamatórios Modelos animais. Epilepsy Anti-inflammatory Agents Animal models. |
title_short |
Effect of anti-inflammators on seizures induced by pentylenetetrazole in the Kindling model: a review |
title_full |
Effect of anti-inflammators on seizures induced by pentylenetetrazole in the Kindling model: a review |
title_fullStr |
Effect of anti-inflammators on seizures induced by pentylenetetrazole in the Kindling model: a review |
title_full_unstemmed |
Effect of anti-inflammators on seizures induced by pentylenetetrazole in the Kindling model: a review |
title_sort |
Effect of anti-inflammators on seizures induced by pentylenetetrazole in the Kindling model: a review |
author |
Barco, Nicole Magarefo |
author_facet |
Barco, Nicole Magarefo Linartevichi, Vagner Fagnani |
author_role |
author |
author2 |
Linartevichi, Vagner Fagnani |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Barco, Nicole Magarefo Linartevichi, Vagner Fagnani |
dc.subject.por.fl_str_mv |
Epilepsia Antiinflamatorio Modelos animales. Epilepsia Anti-inflamatórios Modelos animais. Epilepsy Anti-inflammatory Agents Animal models. |
topic |
Epilepsia Antiinflamatorio Modelos animales. Epilepsia Anti-inflamatórios Modelos animais. Epilepsy Anti-inflammatory Agents Animal models. |
description |
Introduction: Studies with steroidal and non-steroidal anti-inflammatory drugs in animal models have been carried out in order to verify new therapeutic approaches for the treatment of epilepsy to improve the quality of life of patients with this disease that affects about 65 million people worldwide. Objective: to analyze the relevance of these medications in the treatment of seizures. Methodology: this study is a literature review in order to assess the effects of anti-inflammatory drugs in seizures. Results: the results obtained demonstrate that the animals treated with the steroidal and non-steroidal anti-inflammatory drugs studied had a much lower intensity reduction in convulsive crises without progressing to the Racine 4 scale. Conclusion: It is concluded that the studied steroidal and non-steroidal anti-inflammatory drugs have a protective and reductive effect on inflammatory crises induced by pentilenotetrazol, decreasing the inflammatory cytokines in the central nervous system. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-10-21 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/21581 10.33448/rsd-v10i13.21581 |
url |
https://rsdjournal.org/index.php/rsd/article/view/21581 |
identifier_str_mv |
10.33448/rsd-v10i13.21581 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/21581/19202 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2021 Nicole Magarefo Barco; Vagner Fagnani Linartevichi https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2021 Nicole Magarefo Barco; Vagner Fagnani Linartevichi https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 13; e538101321581 Research, Society and Development; Vol. 10 Núm. 13; e538101321581 Research, Society and Development; v. 10 n. 13; e538101321581 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
_version_ |
1797052789782740992 |