Effect of anti-inflammators on seizures induced by pentylenetetrazole in the Kindling model: a review

Detalhes bibliográficos
Autor(a) principal: Barco, Nicole Magarefo
Data de Publicação: 2021
Outros Autores: Linartevichi, Vagner Fagnani
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/21581
Resumo: Introduction: Studies with steroidal and non-steroidal anti-inflammatory drugs in animal models have been carried out in order to verify new therapeutic approaches for the treatment of epilepsy to improve the quality of life of patients with this disease that affects about 65 million people worldwide. Objective: to analyze the relevance of these medications in the treatment of seizures. Methodology: this study is a literature review in order to assess the effects of anti-inflammatory drugs in seizures. Results: the results obtained demonstrate that the animals treated with the steroidal and non-steroidal anti-inflammatory drugs studied had a much lower intensity reduction in convulsive crises without progressing to the Racine 4 scale. Conclusion: It is concluded that the studied steroidal and non-steroidal anti-inflammatory drugs have a protective and reductive effect on inflammatory crises induced by pentilenotetrazol, decreasing the inflammatory cytokines in the central nervous system.
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spelling Effect of anti-inflammators on seizures induced by pentylenetetrazole in the Kindling model: a reviewEfecto de los antiinflamadores sobre las convulsiones inducidas por pentilenetetrazol en el modelo Kindling: una revisiónEfeito dos anti-inflamatorios nas convulsões induzidas por pentilenotetrazol no modelo de Kindling: uma revisãoEpilepsiaAntiinflamatorioModelos animales.EpilepsiaAnti-inflamatóriosModelos animais.EpilepsyAnti-inflammatory AgentsAnimal models.Introduction: Studies with steroidal and non-steroidal anti-inflammatory drugs in animal models have been carried out in order to verify new therapeutic approaches for the treatment of epilepsy to improve the quality of life of patients with this disease that affects about 65 million people worldwide. Objective: to analyze the relevance of these medications in the treatment of seizures. Methodology: this study is a literature review in order to assess the effects of anti-inflammatory drugs in seizures. Results: the results obtained demonstrate that the animals treated with the steroidal and non-steroidal anti-inflammatory drugs studied had a much lower intensity reduction in convulsive crises without progressing to the Racine 4 scale. Conclusion: It is concluded that the studied steroidal and non-steroidal anti-inflammatory drugs have a protective and reductive effect on inflammatory crises induced by pentilenotetrazol, decreasing the inflammatory cytokines in the central nervous system.Introducción: Se han realizado estudios con antiinflamatorios esteroideos y no esteroideos en modelos animales con el fin de verificar nuevos enfoques terapéuticos para el tratamiento de la epilepsia para mejorar la calidad de vida de los pacientes con esta enfermedad que afecta a cerca de 65 millones de personas en todo el mundo.  Objetivo: analizar la relevancia de estos medicamentos en el tratamiento de las convulsiones. Metodología: este estudio es una revisión de la literatura con el fin de evaluar los efectos de los fármacos antiinflamatorios en las convulsiones. Resultados: los resultados obtenidos demuestran que los animales tratados con los antiinflamatorios esteroideos y no esteroideos estudiados presentaron una reducción de intensidad mucho menor en las crisis convulsivas sin progresar a la escala Racine 4. Conclusión: Se concluye que los antiinflamatorios esteroideos y no esteroideos estudiados tienen un efecto protector y reductor sobre las crisis inflamatorias inducidas por pentilotetrazol, disminuyendo las citocinas inflamatorias en el sistema nervioso central.Introdução: Estudos com anti-inflamatórios esteroidais e não esteroidais em modelo animal tem sido realizados a fim de verificar novas abordagens terapêuticas para o tratamento da epilepsia para melhorar a qualidade de vida dos pacientes portadores desta doença que acomete cerca de 65 milhões de pessoas no mundo. Objetivo: analisar a relevância no tratamento das crises convulsivas destes medicamentos. Metodologia: o presente estudo trata-se de uma revisão de literatura a fim de avaliar os efeitos dos anti-inflamatórios nas crises convulsivas. Resultado: os resultados obtidos demonstram que os animais tratados com os anti-inflamatórios esteroidais e não esteroidais estudados tiveram uma redução de intensidade nas crises convulsivas bem mais baixas sem evolução para a escala 4 de Racine. Conclusão: Conclui-se que os medicamentos anti-inflamatórios esteroidais e não esteroidais estudados tem o efeito protetivo e redutivo nas crises inflamatórias induzidas por pentilenotetrazol diminuindo as citocinas inflamatórias no sistema nervoso central.  Research, Society and Development2021-10-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2158110.33448/rsd-v10i13.21581Research, Society and Development; Vol. 10 No. 13; e538101321581Research, Society and Development; Vol. 10 Núm. 13; e538101321581Research, Society and Development; v. 10 n. 13; e5381013215812525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/21581/19202Copyright (c) 2021 Nicole Magarefo Barco; Vagner Fagnani Linartevichihttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessBarco, Nicole MagarefoLinartevichi, Vagner Fagnani2021-11-21T18:26:28Zoai:ojs.pkp.sfu.ca:article/21581Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:40:58.409981Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Effect of anti-inflammators on seizures induced by pentylenetetrazole in the Kindling model: a review
Efecto de los antiinflamadores sobre las convulsiones inducidas por pentilenetetrazol en el modelo Kindling: una revisión
Efeito dos anti-inflamatorios nas convulsões induzidas por pentilenotetrazol no modelo de Kindling: uma revisão
title Effect of anti-inflammators on seizures induced by pentylenetetrazole in the Kindling model: a review
spellingShingle Effect of anti-inflammators on seizures induced by pentylenetetrazole in the Kindling model: a review
Barco, Nicole Magarefo
Epilepsia
Antiinflamatorio
Modelos animales.
Epilepsia
Anti-inflamatórios
Modelos animais.
Epilepsy
Anti-inflammatory Agents
Animal models.
title_short Effect of anti-inflammators on seizures induced by pentylenetetrazole in the Kindling model: a review
title_full Effect of anti-inflammators on seizures induced by pentylenetetrazole in the Kindling model: a review
title_fullStr Effect of anti-inflammators on seizures induced by pentylenetetrazole in the Kindling model: a review
title_full_unstemmed Effect of anti-inflammators on seizures induced by pentylenetetrazole in the Kindling model: a review
title_sort Effect of anti-inflammators on seizures induced by pentylenetetrazole in the Kindling model: a review
author Barco, Nicole Magarefo
author_facet Barco, Nicole Magarefo
Linartevichi, Vagner Fagnani
author_role author
author2 Linartevichi, Vagner Fagnani
author2_role author
dc.contributor.author.fl_str_mv Barco, Nicole Magarefo
Linartevichi, Vagner Fagnani
dc.subject.por.fl_str_mv Epilepsia
Antiinflamatorio
Modelos animales.
Epilepsia
Anti-inflamatórios
Modelos animais.
Epilepsy
Anti-inflammatory Agents
Animal models.
topic Epilepsia
Antiinflamatorio
Modelos animales.
Epilepsia
Anti-inflamatórios
Modelos animais.
Epilepsy
Anti-inflammatory Agents
Animal models.
description Introduction: Studies with steroidal and non-steroidal anti-inflammatory drugs in animal models have been carried out in order to verify new therapeutic approaches for the treatment of epilepsy to improve the quality of life of patients with this disease that affects about 65 million people worldwide. Objective: to analyze the relevance of these medications in the treatment of seizures. Methodology: this study is a literature review in order to assess the effects of anti-inflammatory drugs in seizures. Results: the results obtained demonstrate that the animals treated with the steroidal and non-steroidal anti-inflammatory drugs studied had a much lower intensity reduction in convulsive crises without progressing to the Racine 4 scale. Conclusion: It is concluded that the studied steroidal and non-steroidal anti-inflammatory drugs have a protective and reductive effect on inflammatory crises induced by pentilenotetrazol, decreasing the inflammatory cytokines in the central nervous system.
publishDate 2021
dc.date.none.fl_str_mv 2021-10-21
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/21581
10.33448/rsd-v10i13.21581
url https://rsdjournal.org/index.php/rsd/article/view/21581
identifier_str_mv 10.33448/rsd-v10i13.21581
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/21581/19202
dc.rights.driver.fl_str_mv Copyright (c) 2021 Nicole Magarefo Barco; Vagner Fagnani Linartevichi
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 Nicole Magarefo Barco; Vagner Fagnani Linartevichi
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 13; e538101321581
Research, Society and Development; Vol. 10 Núm. 13; e538101321581
Research, Society and Development; v. 10 n. 13; e538101321581
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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